公开(公告)号：CA2658896A1

公开(公告)日：2008-01-31

申请号：CA2658896

申请日：2007-07-24

Applicant: ABBOTT LAB

Inventor： VISWANATH SHEKHAR ,  BARTELT LARRY ,  ZHANG GEOFF ,  CHEN SHUANG ,  BORCHARDT THOMAS ,  LEANNA ROBERT ,  HENRY RODGER ,  DHAON MADHUP ,  RASMUSSEN MICHAEL

IPC: C07D498/18 ,  A61K31/395 ,  A61K31/4353 ,  A61P37/06

Abstract: A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate. The rapamycin analog can have a structure of Formula (I), which is optionally a prodrug, salt, derivative, or combination thereof: Formula (I)

公开(公告)号：AU2007276837B2

公开(公告)日：2013-02-07

申请号：AU2007276837

申请日：2007-07-24

Applicant: ABBOTT LAB

Inventor： LEANNA ROBERT ,  BORCHARDT THOMAS ,  VISWANATH SHEKHAR ,  CHEN SHUANG ,  BARTELT LARRY ,  RASMUSSEN MICHAEL ,  ZHANG GEOFF ,  HENRY RODGER ,  DHAON MADHUP

IPC: C07D498/18 ,  A61K31/395 ,  A61K31/4353 ,  A61P37/06

Abstract: A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate. The rapamycin analog can have a structure of Formula (I), which is optionally a prodrug, salt, derivative, or combination thereof: Formula (I)

公开(公告)号：NZ574654A

公开(公告)日：2012-03-30

申请号：NZ57465407

申请日：2007-07-24

Applicant: ABBOTT LAB

Inventor： VISWANATH SHEKHAR ,  BARTELT LARRY ,  LEANNA ROBERT ,  RASMUSSEN MICHAEL ,  DHAON MADHUP ,  HENRY RODGER ,  BORCHARDT THOMAS ,  CHEN SHUANG ,  ZHANG GEOFF

IPC: C07D498/18 ,  A61K31/395 ,  A61K31/4353 ,  A61P37/06

Abstract: Disclosed is a rapamycin analog of formula (I). Also disclosed are crystalline forms of the analogues with powder diffraction patterns as disclosed in the specification; a composition comprising a compound of formula (I); a process for preparing a crystalline form of a compound of formula (I).

公开(公告)号：BRPI0714945A2

公开(公告)日：2013-05-21

申请号：BRPI0714945

申请日：2007-07-24

Applicant: ABBOTT LAB

Inventor： VISWANATH SHEKHAR ,  BARTELT LARRY ,  LEANNA ROBERT ,  RASMUSSEN MICHAEL ,  DHAON MADHUP ,  HENRY RODGER ,  BORCHARDT THOMAS ,  CHEN SHUANG ,  ZHANG GEOFF

IPC: C07D498/18 ,  A61K31/395 ,  A61K31/4353 ,  A61P37/06

Abstract: A process for preparing a crystalline form of a rapamycin analog, which process comprises: combining the rapamycin analog with at least one organic medium to form a mixture that is saturated with the rapamycin analog; incubating the saturated mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog from the organic medium.

公开(公告)号：ZA200900740B

公开(公告)日：2010-05-26

申请号：ZA200900740

申请日：2007-07-24

Applicant: ABBOTT LAB

Inventor： VISWANATH SHEKHAR ,  BARTELT LARRY ,  LEANNA ROBERT ,  RASMUSSEN MICHAEL ,  DHAON MADHUP ,  HENRY RODGER ,  BORCHARDT THOMAS ,  CHEN SHUANG ,  ZHANG GEOFF

IPC: A61K20100101 ,  A61P20100101 ,  C07D20100101

公开(公告)号：MX2009001067A

公开(公告)日：2009-06-17

申请号：MX2009001067

申请日：2007-07-24

Applicant: ABBOTT LAB

Inventor： BORCHARDT THOMAS ,  HENRY RODGER ,  DHAON MADHUP ,  VISWANATH SHEKHAR ,  BARTELT LARRY ,  LEANNA ROBERT ,  RASMUSSEN MICHAEL ,  CHEN SHUANG ,  ZHANG GEOFF

IPC: C07D498/18 ,  A61K31/395 ,  A61K31/4353 ,  A61P37/06

Abstract: Una composición de análogo de rapamicina incluye una forma cristalina de un análogo de rapamicina. El cristal puede ser un hidrato, dehidrato, solvato, o desolvato. El análogo de rapamicina puede tener una estructura de la Fórmula (I), el cual es opcionalmente un profármaco, sal, derivado, o combinación de los mismos: Fórmula (I).

公开(公告)号：AU2007276837A1

公开(公告)日：2008-01-31

申请号：AU2007276837

申请日：2007-07-24

Applicant: ABBOTT LAB

Inventor： ZHANG GEOFF ,  BORCHARDT THOMAS ,  VISWANATH SHEKHAR ,  RASMUSSEN MICHAEL ,  CHEN SHUANG ,  DHAON MADHUP ,  HENRY RODGER ,  BARTELT LARRY ,  LEANNA ROBERT

IPC: C07D498/18 ,  A61K31/395 ,  A61K31/4353 ,  A61P37/06

Abstract: A process for preparing a crystalline form of a rapamycin analog, which process comprises: combining the rapamycin analog with at least one organic medium to form a mixture that is saturated with the rapamycin analog; incubating the saturated mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog from the organic medium.