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1.发明申请
公开(公告)号：WO0078773A3
公开(公告)日：2001-02-22
申请号：PCT/US0016579
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
CPC classification number: C07H17/08
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4"-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
Abstract translation: 一方面，本发明涉及一种制备6-O-取代的红霉素衍生物的方法，包括在钯催化剂和膦存在下使2'-取代的和任选的4'-取代的9-肟红霉素衍生物与烷基化剂反应。 另一方面，本发明涉及使用钯催化的烷基化反应制备6-O-取代的红霉素酮内酯的方法。
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公开(公告)号：WO9834917A3
公开(公告)日：1999-01-14
申请号：PCT/US9802439
申请日：1998-02-06
Applicant: ABBOTT LAB
Inventor： LEANNA M ROBERT , HANNICK STEVEN M , RASMUSSEN MICHAEL , TIEN JIEN-HEH J , BHAGAVATULA LAKSHMI , SINGAM PULLA REDDY , GATES BRADLEY D , KOLACZKOWSKI LAWRENCE , PATEL RAMESH R , WAYNE GREG , LANNOYE GREG , ZHANG WEIJIANG , TIAN ZHENPING , LUKIN KIRILL L , NARAYANAN BIKSHANDARKOR A , RILEY DAVID A , MORTON HOWARD , CHANG SOU-JEN
IPC: C12P7/62 , A61K31/52 , A61P31/12 , A61P31/18 , A61P31/22 , C07C69/16 , C07C309/73 , C07D473/18 , C07D473/40 , C07D73/00
CPC classification number: C07D473/18
Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of formula (I) where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a -C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.
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公开(公告)号：DE60019976T2
公开(公告)日：2006-02-16
申请号：DE60019976
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN , WITTENBERGER
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：AU779219B2
公开(公告)日：2005-01-13
申请号：AU5742900
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：CA2375364C
公开(公告)日：2008-11-25
申请号：CA2375364
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： MCLAUGHLIN MAUREEN A , HAIGHT ANTHONY R , MORTON HOWARD E , PETERSON MATTHEW J , GRIEME TIM , RILEY DAVID , DESHPANDE MAHENDRA N , WITTENBERGER STEVEN J , NAPIER JAMES J , TIEN JIEN-HEH J , RAJE PRASAD S , PLATA DANIEL J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , KING STEVEN A , RASMUSSEN MICHAEL , STONER ERIC J , HSU MARGARET CHI-PING , LEE ELAINE C , LEANNA MARVIN R , HILL DAVID R
IPC: C07H17/08 , A61K31/7048 , A61P31/04 , C07B61/00 , C07H1/00
Abstract: In one aspect, the invention relates to a process for preparing 6-O- substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4"-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates t o processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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Patent Agency Ranking
公开(公告)号：CA2658896A1
公开(公告)日：2008-01-31
申请号：CA2658896
申请日：2007-07-24
Applicant: ABBOTT LAB
Inventor： VISWANATH SHEKHAR , BARTELT LARRY , ZHANG GEOFF , CHEN SHUANG , BORCHARDT THOMAS , LEANNA ROBERT , HENRY RODGER , DHAON MADHUP , RASMUSSEN MICHAEL
IPC: C07D498/18 , A61K31/395 , A61K31/4353 , A61P37/06
Abstract: A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate. The rapamycin analog can have a structure of Formula (I), which is optionally a prodrug, salt, derivative, or combination thereof: Formula (I)
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公开(公告)号：AT294809T
公开(公告)日：2005-05-15
申请号：AT00942860
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：CA2375364A1
公开(公告)日：2000-12-28
申请号：CA2375364
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： MORTON HOWARD E , HAIGHT ANTHONY R , MCLAUGHLIN MAUREEN A , GRIEME TIM , RASMUSSEN MICHAEL , HSU MARGARET CHI-PING , KING STEVEN A , RILEY DAVID , WITTENBERGER STEVEN J , TIEN JIEN-HEH J , LEANNA MARVIN R , RAJE PRASAD S , HILL DAVID R , PLATA DANIEL J , DESHPANDE MAHENDRA N , COOPER ARTHUR J , KU YI-YIN , CINK RUSSELL D , LEE ELAINE C , PETERSON MATTHEW J , STONER ERIC J , NAPIER JAMES J
Abstract: In one aspect, the invention relates to a process for preparing 6-O- substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4"-substituted 9-oxime erythromycin derivatives with an alkylatin g agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：AU2007276837B2
公开(公告)日：2013-02-07
申请号：AU2007276837
申请日：2007-07-24
Applicant: ABBOTT LAB
Inventor： LEANNA ROBERT , BORCHARDT THOMAS , VISWANATH SHEKHAR , CHEN SHUANG , BARTELT LARRY , RASMUSSEN MICHAEL , ZHANG GEOFF , HENRY RODGER , DHAON MADHUP
IPC: C07D498/18 , A61K31/395 , A61K31/4353 , A61P37/06
Abstract: A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate. The rapamycin analog can have a structure of Formula (I), which is optionally a prodrug, salt, derivative, or combination thereof: Formula (I)
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公开(公告)号：NZ574654A
公开(公告)日：2012-03-30
申请号：NZ57465407
申请日：2007-07-24
Applicant: ABBOTT LAB
Inventor： VISWANATH SHEKHAR , BARTELT LARRY , LEANNA ROBERT , RASMUSSEN MICHAEL , DHAON MADHUP , HENRY RODGER , BORCHARDT THOMAS , CHEN SHUANG , ZHANG GEOFF
IPC: C07D498/18 , A61K31/395 , A61K31/4353 , A61P37/06
Abstract: Disclosed is a rapamycin analog of formula (I). Also disclosed are crystalline forms of the analogues with powder diffraction patterns as disclosed in the specification; a composition comprising a compound of formula (I); a process for preparing a crystalline form of a compound of formula (I).
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