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1.发明专利Condensed aza bicyclic compound inhibiting vanilloid receptor subtype 1 (vr1) receptor 审中-公开浓缩AZA双相化合物抑制VANILLOID受体亚型1（VR1）受体
公开(公告)号：JP2012072145A
公开(公告)日：2012-04-12
申请号：JP2011226490
申请日：2011-10-14
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： BAYBURT EROL K , DIDOMENICO STANLEY JR , DRIZIN IRENE , GOMTSYAN ARTHUR R , KOENIG JOHN R , PERNER RICHARD J , SCHMIDT ROBERT G JR , TURNER SEAN C , WHITE TAMMIE K , ZHENG GUO ZHU , LEE CHIH-HUNG
IPC: C07D209/08 , A61K31/404 , A61K31/416 , A61K31/454 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/502 , A61K31/5377 , A61K31/541 , A61K31/55 , A61P13/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D217/02 , C07D217/24 , C07D231/56 , C07D237/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02
Abstract: PROBLEM TO BE SOLVED: To provide a novel VR1 antagonist useful for treatment of pain, inflammatory thermalgesia, urorrhea and bladder hyperactivity.SOLUTION: The compound is represented by formula (I) (wherein Xto Xare each a nitrogen atom or the like; R, Rand Rare each a hydrogen atom or the like; Zand Zare each an oxygen atom or the like; and L is an alkenylene or the like).
Abstract translation: 要解决的问题：提供一种新颖的VR1拮抗剂，可用于治疗疼痛，炎症性热痛，尿痛和膀胱多动症。 解决方案：化合物由式（I）表示（其中X
1 至X 5 分别为氮原子 每个都是R＆lt; SB POS =“POST”> 8a ，R 8b 和R 9 氢原子等; Z 1 ，Z 2 分别为氧原子等; L为亚烯基 或类似物）。 版权所有（C）2012，JPO＆INPIT -
2.发明专利Fused azabicyclic compounds which inhibit vanilloid receptor subtype 1 (vr1) receptor 审中-公开不含VANILLOID受体亚型1（VR1）受体的融合的异丁烯酸化合物
公开(公告)号：JP2011026326A
公开(公告)日：2011-02-10
申请号：JP2010200674
申请日：2010-09-08
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： LEE CHIH-HUNG , BAYBURT EROL K , DIDOMENICO STANLEY JR , DRIZIN IRENE , GOMTSYAN ARTHUR R , KOENIG JOHN R , PERNER RICHARD J , SCHMIDT ROBERT G , TURNER SEAN C , WHITE TAMMIE K , ZHENG GUO ZHU
IPC: C07D209/08 , A61K31/404 , A61K31/416 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/502 , A61K31/5377 , A61K31/541 , A61K31/55 , A61P13/02 , A61P43/00 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/56 , C07D237/28 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D521/00
CPC classification number: C07D249/08 , A61K31/404 , A61K31/416 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
Abstract: PROBLEM TO BE SOLVED: To provide the compounds and medicinal compositions useful in treating disorders induced or deteriorated by vanilloid receptor subtype 1 (VR1) activity. SOLUTION: There are provided the compounds represented by formula (I). The compounds are new VR1 antagonists which are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and hyperactive bladder. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 待解决的问题：提供可用于治疗由香草素受体亚型1（VR1）活性诱导或恶化的病症的化合物和药物组合物。 提供由式（I）表示的化合物。 这些化合物是新的VR1拮抗剂，可用于治疗疼痛，炎症性热痛觉过敏，尿失禁和膀胱活动过度。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：WO2005007642A3
公开(公告)日：2005-05-26
申请号：PCT/US2004021836
申请日：2004-07-09
Applicant: ABBOTT LAB , ZHENG GUO ZHU , BROWN BRIAN S , TURNER SEAN C , WHITE TAMMIE K , SCHMIDT ROBERT G , KOENIG JOHN R , LEE CHIH-HUNG
Inventor： ZHENG GUO ZHU , BROWN BRIAN S , TURNER SEAN C , WHITE TAMMIE K , SCHMIDT ROBERT G , KOENIG JOHN R , LEE CHIH-HUNG
IPC: A61P25/04 , C07D401/04 , C07D487/08 , A61K31/4525 , A61K31/4995 , C07D401/12
CPC classification number: C07D401/04 , C07D487/08
Abstract: The present invention relates to compounds of formula (I-VII) (I), or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7and R8 are defined herein. The present invention also relates to methods of trating pain using these compounds and pharmaceutical compositions including these compounds.
Abstract translation: 本发明涉及式（I-VII）（I）化合物或其药学上可接受的盐或前药，其中A，L，R6，R7和R8如本文所定义。 本发明还涉及使用这些化合物和包括这些化合物的药物组合物来治疗疼痛的方法。
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公开(公告)号：BRPI0413305A
公开(公告)日：2006-10-10
申请号：BRPI0413305
申请日：2004-08-04
Applicant: ABBOTT LAB
Inventor： BAYBURT EROL K , DIDOMENICO STANLEY JR , DRIZIN IRENE , GOMTSYAN ARTHUR R , KOENIG JOHN R , PENNER RICHARD J , SCHMIDT ROBERT G JR , TURNER SEAN C , WHITE TAMMIE K , ZHENG GUO ZHU , LEE CHIH-HUNG
IPC: C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/56 , C07D237/28 , C07D401/12 , C07D405/12 , C07D521/00 , C07D403/12 , C07D451/02 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377
Abstract: Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X 1 , X 2 , X 3 , X 4 , X 5 , R 5 , R 6 , R 7 , R 8a , R 8b , R 9 , Z 1 , Z 2 and L are as defined in the description.
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公开(公告)号：CA2743534A1
公开(公告)日：2005-02-24
申请号：CA2743534
申请日：2004-08-04
Applicant: ABBOTT LAB
Inventor： LEE CHIH-HUNG , BAYBURT EROL K , DIDOMENICO STANLEY JR , DRIZIN IRENE , GOMTSYAN ARTHUR R , KOENIG JOHN R , PERNER RICHARD J , SCHMIDT ROBERT G JR , TURNER SEAN C , WHITE TAMMIE K , ZHENG GUO ZHU
IPC: C07D231/56 , A61K31/416 , A61K31/439 , A61K31/46 , A61K31/472 , A61K31/55 , A61P13/10 , C07D217/02 , C07D401/12 , C07D403/12 , C07D451/02 , C07D471/08
Abstract: Compounds of formula (I) (see formula (I)) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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Patent Agency Ranking
公开(公告)号：CA2534542A1
公开(公告)日：2005-02-24
申请号：CA2534542
申请日：2004-08-04
Applicant: ABBOTT LAB
Inventor： WHITE TAMMIE K , ZHENG GUO ZHU , TURNER SEAN C , SCHMIDT ROBERT G JR , DRIZIN IRENE , PERNER RICHARD J , KOENIG JOHN R , GOMTSYAN ARTHUR R , DIDOMENICO STANLEY JR , BAYBURT EROL K , LEE CHIH-HUNG
IPC: C07D217/24 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/26 , C07D231/56 , C07D237/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D451/02 , C07D521/00
Abstract: Compounds of Formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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7.发明专利
公开(公告)号：MXPA06001396A
公开(公告)日：2007-02-13
申请号：MXPA06001396
申请日：2004-08-04
Applicant: ABBOTT LAB
Inventor： BAYBURT EROL K , LEE CHIH-HUNG , KOENIG JOHN R , ZHENG GUO ZHU , TURNER SEAN C , WHITE TAMMIE K , DIDOMENICO STANLEY JR , DRIZIN IRENE , GOMTSYAN ARTHUR R , PENNER RICHARD J , SCHMIDT ROBERT G JR
IPC: C07D217/24 , A61K31/5377 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/26 , C07D231/56 , C07D237/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D451/02 , C07D521/00
Abstract: Ver formula (I) Los compuestos de la Formula (I) son novedosos antagonistas de VR1, que son utiles en el tratamiento de dolor, hiperalgesia termica inflamatoria, incontinencia urinaria, e hiperactividad de la vejiga.
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公开(公告)号：CA2532057A1
公开(公告)日：2005-01-27
申请号：CA2532057
申请日：2004-07-09
Applicant: ABBOTT LAB
Inventor： WHITE TAMMIE K , SCHMIDT ROBERT G , TURNER SEAN C , BROWN BRIAN S , KOENIG JOHN R , LEE CHIH-HUNG , ZHENG GUO ZHU
IPC: C07D401/04 , A61K31/4525 , A61K31/4995 , A61P25/04 , C07D401/12 , C07D487/08
Abstract: The present invention relates to compounds of formula (I-VII) (I), or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7an d R8 are defined herein. The present invention also relates to methods of trating pain using these compounds and pharmaceutical compositions including these compounds.
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公开(公告)号：DE602004017196D1
公开(公告)日：2008-11-27
申请号：DE602004017196
申请日：2004-08-04
Applicant: ABBOTT LAB
Inventor： BAYBURT EROL K , DIDOMENICO STANLEY JR , DRIZIN IRENE , GOMTSYAN ARTHUR R , KOENIG JOHN R , PENNER RICHARD J , SCHMIDT ROBERT G , TURNER SEAN C , WHITE TAMMIE K , ZHENG GUO ZHU
IPC: C07D217/24 , A61K31/47 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/26 , C07D231/56 , C07D237/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D451/02 , C07D521/00
Abstract: Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X 1 , X 2 , X 3 , X 4 , X 5 , R 5 , R 6 , R 7 , R 8a , R 8b , R 9 , Z 1 , Z 2 and L are as defined in the description.
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公开(公告)号：BRPI0412438A
公开(公告)日：2006-09-05
申请号：BRPI0412438
申请日：2004-07-09
Applicant: ABBOTT LAB
Inventor： ZHENG GUO ZHU , BROWN BRIAN S , TURNER SEAN C , WHITE TAMMIE K , SCHMIDT ROBERT G , KOENIG JOHN R , LEE CHIH-HUNG
IPC: A61P25/04 , C07D401/04 , C07D487/08 , C07D401/12 , A61K31/4525
Abstract: The present invention relates to compounds of formula (I) that useful in treating pain.
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