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    DEVICES HAVING SUBSURFACE FLOW AND THEIR USE IN DIAGNOSTIC ASSAYS
    1.
    发明申请
    DEVICES HAVING SUBSURFACE FLOW AND THEIR USE IN DIAGNOSTIC ASSAYS 审中-公开
    具有表面流动的装置及其在诊断测定中的使用

    公开(公告)号：WO1995017965A1

    公开(公告)日：1995-07-06

    申请号：PCT/US1994014510

    申请日：1994-12-16

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  BERMAN, Marvin ,  FORNEY, Kevin, J. ,  GEIST, Jill, M. ,  KORN, Jacqueline, J. ,  LANGNER, Thomas, J. ,  LOOMIS, Neil, W. ,  MORICI, Laura, S. ,  MUETTERTIES, Andrew, J. ,  PARSONS, Robert, G. ,  PUTMAN, Jill, M. ,  ROPELLA, Paul, J. ,  SCHAPIRA, Thomas, G. ,  SIEGEL, Neal, A. ,  WAGNER, Brian, K. ,  BASORE, Bob, O.

    IPC: B01L03/00

    CPC classification number: G01N33/521 ,  B01L3/0241 ,  B01L3/5023 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2300/0825 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406

    Abstract: The present invention is directed to improving the performance of assays using a disposable assay device which includes a porous material (20) in liquid communication with a capillary track (18). In particular, the capillary track (18) is used in conjunction with the solid support to direct test sample and assay reagents directly to a defined reaction site (22) on or in the porous material (20). Signal development at the reaction site (22) indicates the assay result. The present invention is also directed to the construction of a disposable assay device (10) which includes a capillary track (18). In particular, the capillary track is formed by printing a fluid insoluble material (25a), in the reverse image of the desired capillary track (18), on a film layer (23) and then capping the printed material. Alternatively, the capillary track (18) is formed by printing a fluid insoluble material, in the reverse image (30) of the desired capillary track (18), on a porous material (25b) which is then sandwiched between two film layers (23, 26). The present invention is also directed to a drop-forming means (50) which may incorporate one or more assay reagents to allow for improved sample processing and reagent addition, mixing and incubation.

    Abstract translation: 本发明涉及使用包括与毛细管道（18）液体连通的多孔材料（20）的一次性测定装置来改进测定的性能。 特别地，毛细管轨道（18）与固体支持物一起使用，以将测试样品和测定试剂直接引导到多孔材料（20）上或多孔材料（20）中的限定的反应位点（22）。 反应位点（22）的信号发育表明测定结果。 本发明还涉及包括毛细管轨道（18）的一次性分析装置（10）的构造。 特别地，通过在所需毛细管轨迹（18）的反向图像中将薄膜层（23）上的流体不溶性材料（25a）印刷，然后对印刷材料进行封盖来形成毛细管轨迹。 或者，毛细管轨道（18）通过在所需毛细管轨道（18）的反向图像（30）中的多孔材料（25b）上印刷流体不溶性材料而形成，然后夹在两个膜层（23 ，26）。 本发明还涉及一种液滴形成装置（50），其可以掺入一种或多种测定试剂以允许改进的样品处理和试剂添加，混合和孵育。

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