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    DEVICES HAVING SUBSURFACE FLOW AND THEIR USE IN DIAGNOSTIC ASSAYS
    1.
    发明申请
    DEVICES HAVING SUBSURFACE FLOW AND THEIR USE IN DIAGNOSTIC ASSAYS 审中-公开
    具有表面流动的装置及其在诊断测定中的使用

    公开(公告)号：WO1995017965A1

    公开(公告)日：1995-07-06

    申请号：PCT/US1994014510

    申请日：1994-12-16

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  BERMAN, Marvin ,  FORNEY, Kevin, J. ,  GEIST, Jill, M. ,  KORN, Jacqueline, J. ,  LANGNER, Thomas, J. ,  LOOMIS, Neil, W. ,  MORICI, Laura, S. ,  MUETTERTIES, Andrew, J. ,  PARSONS, Robert, G. ,  PUTMAN, Jill, M. ,  ROPELLA, Paul, J. ,  SCHAPIRA, Thomas, G. ,  SIEGEL, Neal, A. ,  WAGNER, Brian, K. ,  BASORE, Bob, O.

    IPC: B01L03/00

    CPC classification number: G01N33/521 ,  B01L3/0241 ,  B01L3/5023 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2300/0825 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406

    Abstract: The present invention is directed to improving the performance of assays using a disposable assay device which includes a porous material (20) in liquid communication with a capillary track (18). In particular, the capillary track (18) is used in conjunction with the solid support to direct test sample and assay reagents directly to a defined reaction site (22) on or in the porous material (20). Signal development at the reaction site (22) indicates the assay result. The present invention is also directed to the construction of a disposable assay device (10) which includes a capillary track (18). In particular, the capillary track is formed by printing a fluid insoluble material (25a), in the reverse image of the desired capillary track (18), on a film layer (23) and then capping the printed material. Alternatively, the capillary track (18) is formed by printing a fluid insoluble material, in the reverse image (30) of the desired capillary track (18), on a porous material (25b) which is then sandwiched between two film layers (23, 26). The present invention is also directed to a drop-forming means (50) which may incorporate one or more assay reagents to allow for improved sample processing and reagent addition, mixing and incubation.

    Abstract translation: 本发明涉及使用包括与毛细管道（18）液体连通的多孔材料（20）的一次性测定装置来改进测定的性能。 特别地，毛细管轨道（18）与固体支持物一起使用，以将测试样品和测定试剂直接引导到多孔材料（20）上或多孔材料（20）中的限定的反应位点（22）。 反应位点（22）的信号发育表明测定结果。 本发明还涉及包括毛细管轨道（18）的一次性分析装置（10）的构造。 特别地，通过在所需毛细管轨迹（18）的反向图像中将薄膜层（23）上的流体不溶性材料（25a）印刷，然后对印刷材料进行封盖来形成毛细管轨迹。 或者，毛细管轨道（18）通过在所需毛细管轨道（18）的反向图像（30）中的多孔材料（25b）上印刷流体不溶性材料而形成，然后夹在两个膜层（23 ，26）。 本发明还涉及一种液滴形成装置（50），其可以掺入一种或多种测定试剂以允许改进的样品处理和试剂添加，混合和孵育。

    ASSAY DEVICES USING SUBSURFACE FLOW
    2.
    发明申请
    ASSAY DEVICES USING SUBSURFACE FLOW 审中-公开
    使用表面流测定装置

    公开(公告)号：WO1994009366A1

    公开(公告)日：1994-04-28

    申请号：PCT/US1993008751

    申请日：1993-09-16

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  FORNEY, Kevin, J. ,  GEIST, Jill, M. ,  LOOMIS, Neil, W. ,  MORICI, Laura, S. ,  MUETTERTIES, Andrew, J. ,  PARSONS, Robert, G. ,  PUTMAN, Jill, M. ,  ROPELLA, Paul, J. ,  SCHAPIRA, Thomas, G. ,  SIEGEL, Neal, A. ,  WAGNER, Brian, K. ,  BASORE, Bob, O.

    IPC: G01N33/543

    CPC classification number: B01L3/502707 ,  B01L3/5023 ,  B01L3/50273 ,  B01L2200/16 ,  B01L2300/069 ,  B01L2300/0825 ,  B01L2400/0406 ,  G01N33/54366 ,  G01N33/54386

    Abstract: The present invention is directed to improving the performance of assays using a disposable assay device which includes a porous material in liquid communication with a capillary track. In particular, the capillary track is used in conjunction with the solid support to direct test sample and assay reagents directly to a defined reaction site on or in the porous material. Signal development at the reaction site indicates the assay result. The present invention is also directed to the construction of a disposable assay device which includes a capillary track. In particular, the cappillary track is formed by printing a fluid insoluble material, in the reverse image of the desired capillary track, on a film layer and then capping the printed material. Alternatively, the capillary track is formed by printing a fluid insoluble material, in the reverse image of the desired capillary track, on a porous material which is then sandwiched between two film layers.

    Abstract translation: 本发明涉及使用包括与毛细管轨道液体连通的多孔材料的一次性测定装置来改进测定的性能。 特别地，毛细管轨道与固体支持物一起使用以将测试样品和测定试剂直接引导至多孔材料上或其中的限定的反应位点。 反应位点的信号发育表明测定结果。 本发明还涉及包括毛细管轨迹的一次性测定装置的构造。 特别地，通过在所需毛细管轨迹的反向图像中将流体不溶性材料印刷在膜层上并且然后对印刷材料进行封盖而形成毛细管轨迹。 或者，毛细管轨迹是通过在所需毛细管轨道的反向图像中印刷流体不溶性材料形成在多孔材料上，然后夹在两个膜层之间。

    IMPROVED AGGLUTINATION REACTION DEVICE UTILIZING POROUS ABSORBENT MATERIAL
    3.
    发明申请
    IMPROVED AGGLUTINATION REACTION DEVICE UTILIZING POROUS ABSORBENT MATERIAL 审中-公开
    改进的聚合反应装置利用多孔吸收材料

    公开(公告)号：WO1992008973A1

    公开(公告)日：1992-05-29

    申请号：PCT/US1991008573

    申请日：1991-11-15

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  ROPELLA, Paul, J. ,  PARSONS, Robert, G. ,  FORNEY, Kevin, J. ,  BASORE, Bob, O. ,  MUETTERTIES, Andrew, J.

    IPC: G01N31/22

    CPC classification number: G01N33/5304 ,  G01N33/54366

    Abstract: Disclosed is an improved device (10) for performing agglutination reactions having at least one chamber (10) having a reaction zone and a distal zone, in which chamber agglutination reactions can be performed. The improvement comprises utilization in the device of means for controlling the overall rate of liquid flow through the chamber (22), the means comprising a layer of liquid absorbant material (22) selectively impregnated with a substance to form an impregnated region and a non-impregnated region wherein the non-impregnated region is liquid absorbant and the impregnated region is liquid-occlusive. The non-impregnated region is in liquid communication with the distal zone of the chamber (10).

    Abstract translation: 公开了一种用于进行凝集反应的改进装置（10），其具有至少一个具有反应区和远端区的室（10），其中可以进行腔室凝集反应。 该改进包括在装置中利用用于控制通过腔室（22）的液体流速的装置的装置，该装置包括选择性浸渍物质以形成浸渍区域的液体吸收剂材料层（22） 浸渍区域，其中非浸渍区域是液体吸收剂，并且浸渍区域是液体闭塞的。 非浸渍区域与腔室（10）的远端区域液体连通。

    IMPROVED AGGLUTINATION REACTION DEVICE HAVING GEOMETRICALLY MODIFIED CHAMBERS
    4.
    发明申请
    IMPROVED AGGLUTINATION REACTION DEVICE HAVING GEOMETRICALLY MODIFIED CHAMBERS 审中-公开
    改进的几何改型反应装置

    公开(公告)号：WO1992008972A1

    公开(公告)日：1992-05-29

    申请号：PCT/US1991008549

    申请日：1991-11-15

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  PARSONS, Robert, G. ,  BASORE, Bob, O. ,  O'CONNELL, Michael, B. ,  FORNEY, Kevin, J. ,  ROPELLA, Paul, J. ,  MUETTERTIES, Andrew, J.

    IPC: G01N31/22

    CPC classification number: G01N33/5304 ,  B01L3/5027 ,  B01L2300/069 ,  B01L2300/0803 ,  B01L2300/0825 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N33/54366

    Abstract: Disclosed is a device for performing agglutination reactions comprising: in adherent relationship, a first wettable layer (1), a second liquid-occlusive layer (2) parallel to and overlying the first layer (1), and a third layer (3) parallel to and overlying the second layer (2) and having a window for observing particles. The second layer is interposed between, and is in adherent relationship to the first and third layers. The second layer (2) has at least one general slot (25) defining a channel for directing liquid conducted by capillary action through a chamber defined by the slot in conjunction with the first (1) and third (3) layers. The chamber has a proximate zone and a distal zone. The geometry of the chamber is modified to provide flow paths having different rates of flow per unit area along the paths. This arrangement of such different paths in the chamber allows agglutination reactions in the chamber to result in the formation of a non-random pattern of aggregated particles in the distal zone of the chamber. Such a non-random pattern is more readily observable than a random pattern of aggregated particles.

    Abstract translation: 公开了一种用于进行凝集反应的装置，包括：以粘附关系，平行于第一层（1）的第一可湿性层（1），第二液体闭塞层（2）和第三层（3）平行 到达并覆盖第二层（2）并具有用于观察颗粒的窗口。 第二层插入在第一和第三层之间并且与第一和第三层呈贴壁关系。 第二层（2）具有限定通道的至少一个通用槽（25），该通道用于将通过毛细管作用传导的液体引导通过与第一（1）和第三层（3）层结合的槽限定的室。 腔室具有近区域和远端区域。 腔室的几何形状被修改以提供具有沿着路径的每单位面积流速不同的流动路径。 腔室中这种不同路径的这种布置允许腔室中的凝集反应导致在腔室的远侧区域中形成凝集颗粒的非随机图案。 这种非随机图案比聚集颗粒的随机图案更容易观察到。

    REMOVAL OF STRATUM CORNEUM BY MEANS OF LIGHT
    6.
    发明公开
    REMOVAL OF STRATUM CORNEUM BY MEANS OF LIGHT 失效
    卸下HORN层中的光能量

    公开(公告)号：EP1011490A1

    公开(公告)日：2000-06-28

    申请号：EP98911910.2

    申请日：1998-03-20

    Applicant: Abbott Laboratories

    Inventor： LOOMIS, Neil, W. ,  BOJAN, Peter, M. ,  HENNING, Timothy, P. ,  POPE, Mark, R. ,  MUETTERTIES, Andrew, J.

    IPC: A61B17/36

    CPC classification number: A61B18/20 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/15136 ,  A61B2017/00765 ,  A61B2018/00636 ,  A61B2018/1807 ,  A61M2037/0007

    Abstract: A method for increasing the permeability of the stratum corneum by means of a source of light, preferably a laser, more preferably a pulsed laser. By increasing the permeability of the stratum corneum, access to the interstitial fluid is achieved, thereby enabling measurement of analytes in the interstitial fluid. In one aspect, the method comprises the steps of (a) providing a source of light having a wavelength of from about 930 nm to about 1040 nm; and (b) exposing a region of the stratum corneum of the patient to said source of light for a period of time sufficient to form an opening in the stratum corneum. Preferably, exposure of the region of the stratum corneum to the source of light is ceased when an amount of interstitial fluid fills the opening in the stratum corneum, which amount is sufficient to cause the scatter intensity of the light reflected from the surface of the interstitial fluid occupying the opening in the stratum corneum to differ from the scatter intensity of the light reflected from a region of the stratum corneum that is substantially free of interstitial fluid. The invention also involves an apparatus for carrying out the foregoing method.

    REMOVAL OF STRATUM CORNEUM BY MEANS OF LIGHT
    8.
    发明授权
    REMOVAL OF STRATUM CORNEUM BY MEANS OF LIGHT 失效
    卸下HORN层中的光能量

    公开(公告)号：EP1011490B1

    公开(公告)日：2004-09-29

    申请号：EP98911910.2

    申请日：1998-03-20

    Applicant: Abbott Laboratories

    Inventor： LOOMIS, Neil, W. ,  BOJAN, Peter, M. ,  HENNING, Timothy, P. ,  POPE, Mark, R. ,  MUETTERTIES, Andrew, J.

    IPC: A61B18/18 ,  A61B18/20

    CPC classification number: A61B18/20 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/15136 ,  A61B2017/00765 ,  A61B2018/00636 ,  A61B2018/1807 ,  A61M2037/0007

    Abstract: A method for increasing the permeability of the stratum corneum by means of a source of light, preferably a laser, more preferably a pulsed laser. By increasing the permeability of the stratum corneum, access to the interstitial fluid is achieved, thereby enabling measurement of analytes in the interstitial fluid. In one aspect, the method comprises the steps of (a) providing a source of light having a wavelength of from about 930 nm to about 1040 nm; and (b) exposing a region of the stratum corneum of the patient to said source of light for a period of time sufficient to form an opening in the stratum corneum. Preferably, exposure of the region of the stratum corneum to the source of light is ceased when an amount of interstitial fluid fills the opening in the stratum corneum, which amount is sufficient to cause the scatter intensity of the light reflected from the surface of the interstitial fluid occupying the opening in the stratum corneum to differ from the scatter intensity of the light reflected from a region of the stratum corneum that is substantially free of interstitial fluid. The invention also involves an apparatus for carrying out the foregoing method.

    IMPROVED AGGLUTINATION REACTION DEVICE UTILIZING POROUS ABSORBENT MATERIAL
    9.
    发明公开
    IMPROVED AGGLUTINATION REACTION DEVICE UTILIZING POROUS ABSORBENT MATERIAL 失效
    改进的凝集反应采用多孔吸收材料。

    公开(公告)号：EP0557447A1

    公开(公告)日：1993-09-01

    申请号：EP92901199.0

    申请日：1991-11-15

    Applicant: ABBOTT LABORATORIES

    Inventor： ROPELLA, Paul, J. ,  PARSONS, Robert, G. ,  FORNEY, Kevin, J. ,  BASORE, Bob, O. ,  MUETTERTIES, Andrew, J.

    IPC: G01N33

    CPC classification number: G01N33/5304 ,  G01N33/54366

    Abstract: Dispositif amélioré (10) permettant de procéder à des réactions d'agglutination, comportant au moins une chambre (10) présentant une zone de réaction et une zone distale, les réactions d'agglutination ayant lieu dans ladite chambre. L'amélioration comprend l'utilisation dans le dispositif d'un moyen de régulation du débit global de liquide dans la chambre (22), le moyen comprenant une couche de matière absorbant le liquide (22) sélectivement imprégnée d'une substance afin de former une région imprégnée ainsi qu'une région non imprégnée, ladite région non imprégnée absorbant le liquide et ladite région imprégnée arrêtant le liquide. Ladite région non imprégnée est en communication liquide avec la zone distale de la chambre (10).

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