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    DEVICES HAVING SUBSURFACE FLOW AND THEIR USE IN DIAGNOSTIC ASSAYS
    2.
    发明申请
    DEVICES HAVING SUBSURFACE FLOW AND THEIR USE IN DIAGNOSTIC ASSAYS 审中-公开
    具有表面流动的装置及其在诊断测定中的使用

    公开(公告)号：WO1995017965A1

    公开(公告)日：1995-07-06

    申请号：PCT/US1994014510

    申请日：1994-12-16

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  BERMAN, Marvin ,  FORNEY, Kevin, J. ,  GEIST, Jill, M. ,  KORN, Jacqueline, J. ,  LANGNER, Thomas, J. ,  LOOMIS, Neil, W. ,  MORICI, Laura, S. ,  MUETTERTIES, Andrew, J. ,  PARSONS, Robert, G. ,  PUTMAN, Jill, M. ,  ROPELLA, Paul, J. ,  SCHAPIRA, Thomas, G. ,  SIEGEL, Neal, A. ,  WAGNER, Brian, K. ,  BASORE, Bob, O.

    IPC: B01L03/00

    CPC classification number: G01N33/521 ,  B01L3/0241 ,  B01L3/5023 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2300/0825 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406

    Abstract: The present invention is directed to improving the performance of assays using a disposable assay device which includes a porous material (20) in liquid communication with a capillary track (18). In particular, the capillary track (18) is used in conjunction with the solid support to direct test sample and assay reagents directly to a defined reaction site (22) on or in the porous material (20). Signal development at the reaction site (22) indicates the assay result. The present invention is also directed to the construction of a disposable assay device (10) which includes a capillary track (18). In particular, the capillary track is formed by printing a fluid insoluble material (25a), in the reverse image of the desired capillary track (18), on a film layer (23) and then capping the printed material. Alternatively, the capillary track (18) is formed by printing a fluid insoluble material, in the reverse image (30) of the desired capillary track (18), on a porous material (25b) which is then sandwiched between two film layers (23, 26). The present invention is also directed to a drop-forming means (50) which may incorporate one or more assay reagents to allow for improved sample processing and reagent addition, mixing and incubation.

    Abstract translation: 本发明涉及使用包括与毛细管道（18）液体连通的多孔材料（20）的一次性测定装置来改进测定的性能。 特别地，毛细管轨道（18）与固体支持物一起使用，以将测试样品和测定试剂直接引导到多孔材料（20）上或多孔材料（20）中的限定的反应位点（22）。 反应位点（22）的信号发育表明测定结果。 本发明还涉及包括毛细管轨道（18）的一次性分析装置（10）的构造。 特别地，通过在所需毛细管轨迹（18）的反向图像中将薄膜层（23）上的流体不溶性材料（25a）印刷，然后对印刷材料进行封盖来形成毛细管轨迹。 或者，毛细管轨道（18）通过在所需毛细管轨道（18）的反向图像（30）中的多孔材料（25b）上印刷流体不溶性材料而形成，然后夹在两个膜层（23 ，26）。 本发明还涉及一种液滴形成装置（50），其可以掺入一种或多种测定试剂以允许改进的样品处理和试剂添加，混合和孵育。

    ASSAY DEVICES USING SUBSURFACE FLOW
    3.
    发明申请
    ASSAY DEVICES USING SUBSURFACE FLOW 审中-公开
    使用表面流测定装置

    公开(公告)号：WO1994009366A1

    公开(公告)日：1994-04-28

    申请号：PCT/US1993008751

    申请日：1993-09-16

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  FORNEY, Kevin, J. ,  GEIST, Jill, M. ,  LOOMIS, Neil, W. ,  MORICI, Laura, S. ,  MUETTERTIES, Andrew, J. ,  PARSONS, Robert, G. ,  PUTMAN, Jill, M. ,  ROPELLA, Paul, J. ,  SCHAPIRA, Thomas, G. ,  SIEGEL, Neal, A. ,  WAGNER, Brian, K. ,  BASORE, Bob, O.

    IPC: G01N33/543

    CPC classification number: B01L3/502707 ,  B01L3/5023 ,  B01L3/50273 ,  B01L2200/16 ,  B01L2300/069 ,  B01L2300/0825 ,  B01L2400/0406 ,  G01N33/54366 ,  G01N33/54386

    Abstract: The present invention is directed to improving the performance of assays using a disposable assay device which includes a porous material in liquid communication with a capillary track. In particular, the capillary track is used in conjunction with the solid support to direct test sample and assay reagents directly to a defined reaction site on or in the porous material. Signal development at the reaction site indicates the assay result. The present invention is also directed to the construction of a disposable assay device which includes a capillary track. In particular, the cappillary track is formed by printing a fluid insoluble material, in the reverse image of the desired capillary track, on a film layer and then capping the printed material. Alternatively, the capillary track is formed by printing a fluid insoluble material, in the reverse image of the desired capillary track, on a porous material which is then sandwiched between two film layers.

    Abstract translation: 本发明涉及使用包括与毛细管轨道液体连通的多孔材料的一次性测定装置来改进测定的性能。 特别地，毛细管轨道与固体支持物一起使用以将测试样品和测定试剂直接引导至多孔材料上或其中的限定的反应位点。 反应位点的信号发育表明测定结果。 本发明还涉及包括毛细管轨迹的一次性测定装置的构造。 特别地，通过在所需毛细管轨迹的反向图像中将流体不溶性材料印刷在膜层上并且然后对印刷材料进行封盖而形成毛细管轨迹。 或者，毛细管轨迹是通过在所需毛细管轨道的反向图像中印刷流体不溶性材料形成在多孔材料上，然后夹在两个膜层之间。

    SELF-VENTING IMMUNODIAGNOSTIC DEVICES AND METHODS OF PERFORMING ASSAYS
    6.
    发明申请
    SELF-VENTING IMMUNODIAGNOSTIC DEVICES AND METHODS OF PERFORMING ASSAYS 审中-公开
    自我发射免疫组化设备及其测定方法

    公开(公告)号：WO1995017966A1

    公开(公告)日：1995-07-06

    申请号：PCT/US1994014936

    申请日：1994-12-28

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  OOSTA, Gary, M. ,  SCHAPIRA, Thomas, G.

    IPC: B01L03/00

    CPC classification number: G01N33/54386 ,  B01L3/502723 ,  B01L2200/0684 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  Y10T436/255

    Abstract: Methods and devices are provided involving an inlet port, at least one chamber, a channel providing access for fluids to flow through via capillary action or differential pressure, reagents, detection means and self-venting materials. The devices allow for the appropriate mixing, reacting, incubating needed to give a detectable signal which can be read. The self-venting materials allow for the 1) displacement of gases inside a track to the outside of the device and 2) oxygen movement into the track from the outside.

    Abstract translation: 提供的方法和装置包括入口端口，至少一个腔室，通道，用于通过毛细作用或差压流体流过流体，试剂，检测装置和自排气材料。 这些装置允许适当的混合，反应，孵育所需的，以产生可读信号。 自放气材料允许1）将轨道内的气体置换到设备外部，以及2）氧气从外部进入轨道。

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