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    DEVICES HAVING SUBSURFACE FLOW AND THEIR USE IN DIAGNOSTIC ASSAYS
    2.
    发明申请
    DEVICES HAVING SUBSURFACE FLOW AND THEIR USE IN DIAGNOSTIC ASSAYS 审中-公开
    具有表面流动的装置及其在诊断测定中的使用

    公开(公告)号：WO1995017965A1

    公开(公告)日：1995-07-06

    申请号：PCT/US1994014510

    申请日：1994-12-16

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  BERMAN, Marvin ,  FORNEY, Kevin, J. ,  GEIST, Jill, M. ,  KORN, Jacqueline, J. ,  LANGNER, Thomas, J. ,  LOOMIS, Neil, W. ,  MORICI, Laura, S. ,  MUETTERTIES, Andrew, J. ,  PARSONS, Robert, G. ,  PUTMAN, Jill, M. ,  ROPELLA, Paul, J. ,  SCHAPIRA, Thomas, G. ,  SIEGEL, Neal, A. ,  WAGNER, Brian, K. ,  BASORE, Bob, O.

    IPC: B01L03/00

    CPC classification number: G01N33/521 ,  B01L3/0241 ,  B01L3/5023 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2300/0825 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406

    Abstract: The present invention is directed to improving the performance of assays using a disposable assay device which includes a porous material (20) in liquid communication with a capillary track (18). In particular, the capillary track (18) is used in conjunction with the solid support to direct test sample and assay reagents directly to a defined reaction site (22) on or in the porous material (20). Signal development at the reaction site (22) indicates the assay result. The present invention is also directed to the construction of a disposable assay device (10) which includes a capillary track (18). In particular, the capillary track is formed by printing a fluid insoluble material (25a), in the reverse image of the desired capillary track (18), on a film layer (23) and then capping the printed material. Alternatively, the capillary track (18) is formed by printing a fluid insoluble material, in the reverse image (30) of the desired capillary track (18), on a porous material (25b) which is then sandwiched between two film layers (23, 26). The present invention is also directed to a drop-forming means (50) which may incorporate one or more assay reagents to allow for improved sample processing and reagent addition, mixing and incubation.

    Abstract translation: 本发明涉及使用包括与毛细管道（18）液体连通的多孔材料（20）的一次性测定装置来改进测定的性能。 特别地，毛细管轨道（18）与固体支持物一起使用，以将测试样品和测定试剂直接引导到多孔材料（20）上或多孔材料（20）中的限定的反应位点（22）。 反应位点（22）的信号发育表明测定结果。 本发明还涉及包括毛细管轨道（18）的一次性分析装置（10）的构造。 特别地，通过在所需毛细管轨迹（18）的反向图像中将薄膜层（23）上的流体不溶性材料（25a）印刷，然后对印刷材料进行封盖来形成毛细管轨迹。 或者，毛细管轨道（18）通过在所需毛细管轨道（18）的反向图像（30）中的多孔材料（25b）上印刷流体不溶性材料而形成，然后夹在两个膜层（23 ，26）。 本发明还涉及一种液滴形成装置（50），其可以掺入一种或多种测定试剂以允许改进的样品处理和试剂添加，混合和孵育。

    ASSAY DEVICES USING SUBSURFACE FLOW
    3.
    发明申请
    ASSAY DEVICES USING SUBSURFACE FLOW 审中-公开
    使用表面流测定装置

    公开(公告)号：WO1994009366A1

    公开(公告)日：1994-04-28

    申请号：PCT/US1993008751

    申请日：1993-09-16

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  FORNEY, Kevin, J. ,  GEIST, Jill, M. ,  LOOMIS, Neil, W. ,  MORICI, Laura, S. ,  MUETTERTIES, Andrew, J. ,  PARSONS, Robert, G. ,  PUTMAN, Jill, M. ,  ROPELLA, Paul, J. ,  SCHAPIRA, Thomas, G. ,  SIEGEL, Neal, A. ,  WAGNER, Brian, K. ,  BASORE, Bob, O.

    IPC: G01N33/543

    CPC classification number: B01L3/502707 ,  B01L3/5023 ,  B01L3/50273 ,  B01L2200/16 ,  B01L2300/069 ,  B01L2300/0825 ,  B01L2400/0406 ,  G01N33/54366 ,  G01N33/54386

    Abstract: The present invention is directed to improving the performance of assays using a disposable assay device which includes a porous material in liquid communication with a capillary track. In particular, the capillary track is used in conjunction with the solid support to direct test sample and assay reagents directly to a defined reaction site on or in the porous material. Signal development at the reaction site indicates the assay result. The present invention is also directed to the construction of a disposable assay device which includes a capillary track. In particular, the cappillary track is formed by printing a fluid insoluble material, in the reverse image of the desired capillary track, on a film layer and then capping the printed material. Alternatively, the capillary track is formed by printing a fluid insoluble material, in the reverse image of the desired capillary track, on a porous material which is then sandwiched between two film layers.

    Abstract translation: 本发明涉及使用包括与毛细管轨道液体连通的多孔材料的一次性测定装置来改进测定的性能。 特别地，毛细管轨道与固体支持物一起使用以将测试样品和测定试剂直接引导至多孔材料上或其中的限定的反应位点。 反应位点的信号发育表明测定结果。 本发明还涉及包括毛细管轨迹的一次性测定装置的构造。 特别地，通过在所需毛细管轨迹的反向图像中将流体不溶性材料印刷在膜层上并且然后对印刷材料进行封盖而形成毛细管轨迹。 或者，毛细管轨迹是通过在所需毛细管轨道的反向图像中印刷流体不溶性材料形成在多孔材料上，然后夹在两个膜层之间。

    REMOVAL OF STRATUM CORNEUM BY MEANS OF LIGHT
    6.
    发明授权
    REMOVAL OF STRATUM CORNEUM BY MEANS OF LIGHT 失效
    卸下HORN层中的光能量

    公开(公告)号：EP1011490B1

    公开(公告)日：2004-09-29

    申请号：EP98911910.2

    申请日：1998-03-20

    Applicant: Abbott Laboratories

    Inventor： LOOMIS, Neil, W. ,  BOJAN, Peter, M. ,  HENNING, Timothy, P. ,  POPE, Mark, R. ,  MUETTERTIES, Andrew, J.

    IPC: A61B18/18 ,  A61B18/20

    CPC classification number: A61B18/20 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/15136 ,  A61B2017/00765 ,  A61B2018/00636 ,  A61B2018/1807 ,  A61M2037/0007

    Abstract: A method for increasing the permeability of the stratum corneum by means of a source of light, preferably a laser, more preferably a pulsed laser. By increasing the permeability of the stratum corneum, access to the interstitial fluid is achieved, thereby enabling measurement of analytes in the interstitial fluid. In one aspect, the method comprises the steps of (a) providing a source of light having a wavelength of from about 930 nm to about 1040 nm; and (b) exposing a region of the stratum corneum of the patient to said source of light for a period of time sufficient to form an opening in the stratum corneum. Preferably, exposure of the region of the stratum corneum to the source of light is ceased when an amount of interstitial fluid fills the opening in the stratum corneum, which amount is sufficient to cause the scatter intensity of the light reflected from the surface of the interstitial fluid occupying the opening in the stratum corneum to differ from the scatter intensity of the light reflected from a region of the stratum corneum that is substantially free of interstitial fluid. The invention also involves an apparatus for carrying out the foregoing method.

    INTERSTITIAL FLUID COLLECTION AND MONITORING DEVICE
    8.
    发明授权
    INTERSTITIAL FLUID COLLECTION AND MONITORING DEVICE 有权
    设备拆卸和分析组织间液

    公开(公告)号：EP1056396B1

    公开(公告)日：2005-11-09

    申请号：EP99907051.9

    申请日：1999-02-16

    Applicant: ABBOTT LABORATORIES

    Inventor： BOJAN, Peter, M. ,  HENNING, Timothy, P. ,  LOOMIS, Neil, W. ,  POPE, Mark, R. ,  EPPSTEIN, Jonathan

    IPC: A61B10/00 ,  A61K41/00 ,  A61B5/103

    CPC classification number: A61B5/14865 ,  A61B5/14514 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/157 ,  A61B5/441 ,  A61B10/0045 ,  A61B18/20 ,  A61B2010/008 ,  A61B2017/00765 ,  A61B2018/1807 ,  A61B2562/0295 ,  Y10T436/2575

    Abstract: An article (10) capable of both collecting interstitial fluid and detecting an analyte in that fluid and a method for use of that article (10). Preferably, the article (10) is also capable of measuring the amount of analyte in the interstitial fluid. The article (10) can be used in conjunction with a meter that contains an appropriate detection element for determining the amount of analyte in the interstitial fluid. In one preferred embodiment, the article (10) is a multiple-layer element comprising: (1) a layer (15) that is capable of being placed in contact with the skin of a patient; (2) a layer (16) that is coated over the skin-contacting layer (15); (3) a layer (18), substantially coplanar with the overcoat layer (16), that is capable of transporting interstitial fluid by means of chemically aided wicking; (4) a layer (20), overlying the interstitial fluid transporting layer (18), that is capable of being placed in contact with a meter (28), said layer having an opening (24) therein through which light can be transmitted; (5) a layer (28), disposed on the surface of the meter-contacting layer (20) that faces the skin-contacting layer (15), that is capable of detecting the presence of analyte or measuring the amount of analyte in the fluid. In order to use the multiple-layer (18) element (10), light from a source of light is transmitted through the opening (24) in the multiple-layer material to be absorbed at a light-absorbing target (22) on the skin-contacting layer (15). This light transfers energy to the target (22), and this transferred energy causes an opening to form in the skin-contacting layer (15) and an opening to form in the stratum corneum. Interstitial fluid exudes from the opening in the stratum corneum and contacts the interstitial fluid transporting layer (18). The interstitial fluid then moves along or through the interstitial fluid transporting layer (18) to the detecting layer (28).

    REMOVAL OF STRATUM CORNEUM BY MEANS OF LIGHT
    9.
    发明公开
    REMOVAL OF STRATUM CORNEUM BY MEANS OF LIGHT 失效
    卸下HORN层中的光能量

    公开(公告)号：EP1011490A1

    公开(公告)日：2000-06-28

    申请号：EP98911910.2

    申请日：1998-03-20

    Applicant: Abbott Laboratories

    Inventor： LOOMIS, Neil, W. ,  BOJAN, Peter, M. ,  HENNING, Timothy, P. ,  POPE, Mark, R. ,  MUETTERTIES, Andrew, J.

    IPC: A61B17/36

    CPC classification number: A61B18/20 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/15136 ,  A61B2017/00765 ,  A61B2018/00636 ,  A61B2018/1807 ,  A61M2037/0007

    Abstract: A method for increasing the permeability of the stratum corneum by means of a source of light, preferably a laser, more preferably a pulsed laser. By increasing the permeability of the stratum corneum, access to the interstitial fluid is achieved, thereby enabling measurement of analytes in the interstitial fluid. In one aspect, the method comprises the steps of (a) providing a source of light having a wavelength of from about 930 nm to about 1040 nm; and (b) exposing a region of the stratum corneum of the patient to said source of light for a period of time sufficient to form an opening in the stratum corneum. Preferably, exposure of the region of the stratum corneum to the source of light is ceased when an amount of interstitial fluid fills the opening in the stratum corneum, which amount is sufficient to cause the scatter intensity of the light reflected from the surface of the interstitial fluid occupying the opening in the stratum corneum to differ from the scatter intensity of the light reflected from a region of the stratum corneum that is substantially free of interstitial fluid. The invention also involves an apparatus for carrying out the foregoing method.

    INTERSTITIAL FLUID COLLECTION AND MONITORING DEVICE
    10.
    发明公开
    INTERSTITIAL FLUID COLLECTION AND MONITORING DEVICE 有权
    设备拆卸和分析组织间液

    公开(公告)号：EP1056396A1

    公开(公告)日：2000-12-06

    申请号：EP99907051.9

    申请日：1999-02-16

    Applicant: ABBOTT LABORATORIES

    Inventor： BOJAN, Peter, M. ,  HENNING, Timothy, P. ,  LOOMIS, Neil, W. ,  POPE, Mark, R. ,  EPPSTEIN, Jonathan

    IPC: A61B10/00 ,  A61K41/00 ,  A61B5/103

    CPC classification number: A61B5/14865 ,  A61B5/14514 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/157 ,  A61B5/441 ,  A61B10/0045 ,  A61B18/20 ,  A61B2010/008 ,  A61B2017/00765 ,  A61B2018/1807 ,  A61B2562/0295 ,  Y10T436/2575

    Abstract: An article (10) capable of both collecting interstitial fluid and detecting an analyte in that fluid and a method for use of that article (10). Preferably, the article (10) is also capable of measuring the amount of analyte in the interstitial fluid. The article (10) can be used in conjunction with a meter that contains an appropriate detection element for determining the amount of analyte in the interstitial fluid. In one preferred embodiment, the article (10) is a multiple-layer element comprising: (1) a layer (15) that is capable of being placed in contact with the skin of a patient; (2) a layer (16) that is coated over the skin-contacting layer (15); (3) a layer (18), substantially coplanar with the overcoat layer (16), that is capable of transporting interstitial fluid by means of chemically aided wicking; (4) a layer (20), overlying the interstitial fluid transporting layer (18), that is capable of being placed in contact with a meter (28), said layer having an opening (24) therein through which light can be transmitted; (5) a layer (28), disposed on the surface of the meter-contacting layer (20) that faces the skin-contacting layer (15), that is capable of detecting the presence of analyte or measuring the amount of analyte in the fluid. In order to use the multiple-layer (18) element (10), light from a source of light is transmitted through the opening (24) in the multiple-layer material to be absorbed at a light-absorbing target (22) on the skin-contacting layer (15). This light transfers energy to the target (22), and this transferred energy causes an opening to form in the skin-contacting layer (15) and an opening to form in the stratum corneum. Interstitial fluid exudes from the opening in the stratum corneum and contacts the interstitial fluid transporting layer (18). The interstitial fluid then moves along or through the interstitial fluid transporting layer (18) to the detecting layer (28).

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