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公开(公告)号：WO2011068899A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/058598
申请日：2010-12-01
Applicant: ABBOTT LABORATORIES , WISHART, Neil , ARGIRIADI, Maria A. , BREINLINGER, Eric C. , CALDERWOOD, David J. , ERICSSON, Anna M. , FIAMENGO, Bryan A. , FRANK, Kristine E. , FRIEDMAN, Michael , GEORGE, Dawn M. , GOEDKEN, Eric R. , JOSEPHSOHN, Nathan S. , LI, Biqin C. , MORYTKO, Michael J. , MULLEN, Kelly D. , SOMAL, Gagandeep , STEWART, Kent D. , VOSS, Jeffrey W. , WALLACE, Grier A. , WANG, Lu , WOLLER, Kevin R.
Inventor： WISHART, Neil , ARGIRIADI, Maria A. , BREINLINGER, Eric C. , CALDERWOOD, David J. , ERICSSON, Anna M. , FIAMENGO, Bryan A. , FRANK, Kristine E. , FRIEDMAN, Michael , GEORGE, Dawn M. , GOEDKEN, Eric R. , JOSEPHSOHN, Nathan S. , LI, Biqin C. , MORYTKO, Michael J. , MULLEN, Kelly D. , SOMAL, Gagandeep , STEWART, Kent D. , VOSS, Jeffrey W. , WALLACE, Grier A. , WANG, Lu , WOLLER, Kevin R.
CPC classification number: C07F9/06 , C07D471/14 , C07D487/14 , C07D498/14 , C07D513/14
Abstract: The invention provides a compound of Formula (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), or (Il) as defined herein, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
Abstract translation: 本发明提供了式（Ia），（Ib），（Ic），（Id），（Ie），（If），（Ig），（Ih），（Ii），（Ij），（Ik） ，或（II），其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：WO2008076356A1
公开(公告)日：2008-06-26
申请号：PCT/US2007/025602
申请日：2007-12-14
Applicant: ABBOTT LABORATORIES , HOBSON, Adrian D. , FIX-STENZEL, Shannon , CUSACK, Kevin P. , BREINLINGER, Eric C. , ANSELL, Graham K. , STOFFEL, Robert H.
Inventor： HOBSON, Adrian D. , FIX-STENZEL, Shannon , CUSACK, Kevin P. , BREINLINGER, Eric C. , ANSELL, Graham K. , STOFFEL, Robert H.
CPC classification number: C07D271/07 , C07D271/06 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.
Abstract translation: 新型恶二唑化合物，含有这些化合物的药物组合物以及这些化合物或组合物作为G蛋白偶联受体的S1P家族的激动剂或拮抗剂用于治疗与调节S1P家族受体活性有关的疾病的用途，特别是通过提供有益的免疫抑制 效果被公开。
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公开(公告)号：WO2012151158A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/035832
申请日：2012-04-30
Applicant: ABBOTT LABORATORIES , CALDERWOOD, David J. , BREINLINGER, Eric C. , SWANN, Steven L. , MUKHERJEE, Subhendu , CHITTY, Venkata Srikanth , THUNUGUNTLA, Siva Sanjeeva Rao , HOSAHALLI, Subramanyah Seetharama Shastry
Inventor： CALDERWOOD, David J. , BREINLINGER, Eric C. , SWANN, Steven L. , MUKHERJEE, Subhendu , CHITTY, Venkata Srikanth , THUNUGUNTLA, Siva Sanjeeva Rao , HOSAHALLI, Subramanyah Seetharama Shastry
IPC: A61K31/422
CPC classification number: A61K31/506 , A61K31/5377 , A61K31/541 , C07D413/04 , C07D413/12 , C07D413/14 , Y02A50/401 , Y02A50/463 , Y02A50/481
Abstract: The present invention provides compound of Formula (1) biologically active metabolites, pro-drugs, isomers, stereoisomers, solvates, hydrates and pharmaceutically acceptable salts thereof wherein the variables are defined herein. The compounds of the invention are useful for treating immunological conditions. X is an optionally substituted ring system which is aromatic, partly aromatic or non-aromatic having one or more fused ring systems.
Abstract translation: 本发明提供了式（1）化合物的生物活性代谢物，前药，异构体，立体异构体，溶剂合物，水合物及其药学上可接受的盐，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学病症。 X是任选取代的环系，其是具有一个或多个稠环体系的芳香族，部分芳族或非芳族的。
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公开(公告)号：WO2012125797A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/029184
申请日：2012-03-15
Applicant: ABBOTT LABORATORIES , CUSACK, Kevin P. , GORDON, Thomas D. , IHLE, David C. , HAYES, Martin E. , BREINLINGER, Eric C. , ERICSSON, Anna M. , LI, Bin , WANG, Lei , MARTINEZ, Gloria Y. , BURCHAT, Andrew , HOBSON, Adrian D. , MULLEN, Kelly D. , FRIEDMAN, Michael , MORYTKO, Michael, J.
Inventor： CUSACK, Kevin P. , GORDON, Thomas D. , IHLE, David C. , HAYES, Martin E. , BREINLINGER, Eric C. , ERICSSON, Anna M. , LI, Bin , WANG, Lei , MARTINEZ, Gloria Y. , BURCHAT, Andrew , HOBSON, Adrian D. , MULLEN, Kelly D. , FRIEDMAN, Michael , MORYTKO, Michael, J.
IPC: A01N27/00 , A61K31/015
CPC classification number: C07D213/75 , C07B2200/07 , C07C45/62 , C07C45/72 , C07C45/74 , C07C49/755 , C07D231/54 , C07D235/18 , C07D241/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D453/04 , C07D487/06 , C07D491/20 , C07C49/67
Abstract: The invention provides a compound of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
Abstract translation: 本发明提供式（I）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：WO2008118485A1
公开(公告)日：2008-10-02
申请号：PCT/US2008/004007
申请日：2008-03-27
Applicant: ABBOTT LABORATORIES , CALDERWOOD, David J. , FRANK, Kristine E. , BETSCHMANN, Patrick , BREINLINGER, Eric C. , DIXON, Richard W.
Inventor： CALDERWOOD, David J. , FRANK, Kristine E. , BETSCHMANN, Patrick , BREINLINGER, Eric C. , DIXON, Richard W.
IPC: A01N43/58 , A61K31/50 , C07D471/00
CPC classification number: C07D487/04
Abstract: The present invention is directed to novel imidazopyrazine compounds useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
Abstract translation: 本发明涉及用作激酶抑制剂的新颖的咪唑并嗪化合物，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性病症和病症，例如癌症。
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Patent Agency Ranking6.发明申请SPHINGOSINE-1 -PHOSPHATE RECEPTOR AGONIST AND ANTAGONIST COMPOUNDS 审中-公开SPHINGOSINE-1-磷酸酯受体激动剂和拮抗剂化合物
公开(公告)号：WO2008079382A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/026263
申请日：2007-12-21
Applicant: ABBOTT LABORATORIES , WALLACE, Grier A. , BREINLINGER, Eric C. , CUSACK, Kevin P. , FIX-STENZEL, Shannon R. , GORDON, Thomas D. , HOBSON, Adrian D. , HAYES, Martin E. , ANSELL, Graham K. , GRONGSAARD, Pintipa
Inventor： WALLACE, Grier A. , BREINLINGER, Eric C. , CUSACK, Kevin P. , FIX-STENZEL, Shannon R. , GORDON, Thomas D. , HOBSON, Adrian D. , HAYES, Martin E. , ANSELL, Graham K. , GRONGSAARD, Pintipa
IPC: A01N43/50 , A61K31/415
CPC classification number: C07D413/04 , C07C215/38 , C07C215/42 , C07C217/52 , C07C217/74 , C07C229/14 , C07C229/48 , C07C2601/02 , C07C2601/08 , C07D205/04 , C07D207/12 , C07D207/14 , C07D213/30 , C07D263/32 , C07D263/52 , C07D271/06 , C07D307/22 , C07D307/24 , C07D333/16 , C07D491/107 , C07F9/091 , C07F9/301 , C07F9/3808 , C07F9/3826 , C07F9/4006 , C07F9/653 , C07F9/65515 , C07F9/655345
Abstract: The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutics for treating medical conditions associated with agonism or antagonism of the individual receptors of the S1P receptor family.
Abstract translation: 本发明涉及作为S1P受体家族的一种或多种单独受体的激动剂或拮抗剂的新颖的，有效的和选择性的药剂。 本发明的化合物可用作治疗与S1P受体家族的各个受体的激动作用或拮抗作用相关的医学病症的治疗剂。
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公开(公告)号：WO2007084728A3
公开(公告)日：2007-07-26
申请号：PCT/US2007/001548
申请日：2007-01-19
Applicant: ABBOTT LABORATORIES , ROTH, Gregory P. , WALLACE, Grier A. , GEORGE, Dawn M. , GRONGSAARD, Pintipa , HAYES, Martin , BREINLINGER, Eric C.
Inventor： ROTH, Gregory P. , WALLACE, Grier A. , GEORGE, Dawn M. , GRONGSAARD, Pintipa , HAYES, Martin , BREINLINGER, Eric C.
IPC: A61K31/496
Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I), wherein the substituents are as defined herein, which are useful as therapeutic agents.
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8.发明公开SPHINGOSINE-1 -PHOSPHATE RECEPTOR AGONIST AND ANTAGONIST COMPOUNDS 审中-公开SPHINGOSINE-1 -PHOSPHATE受体激动剂和拮抗剂化合物
公开(公告)号：EP2120575A1
公开(公告)日：2009-11-25
申请号：EP07863237.9
申请日：2007-12-21
Applicant: ABBOTT LABORATORIES
Inventor： WALLACE, Grier A. , BREINLINGER, Eric C. , CUSACK, Kevin P. , FIX-STENZEL, Shannon R. , GORDON, Thomas D. , HOBSON, Adrian D. , HAYES, Martin E. , ANSELL, Graham K. , GRONGSAARD, Pintipa
IPC: A01N43/50 , A61K31/415
CPC classification number: C07D413/04 , C07C215/38 , C07C215/42 , C07C217/52 , C07C217/74 , C07C229/14 , C07C229/48 , C07C2601/02 , C07C2601/08 , C07D205/04 , C07D207/12 , C07D207/14 , C07D213/30 , C07D263/32 , C07D263/52 , C07D271/06 , C07D307/22 , C07D307/24 , C07D333/16 , C07D491/107 , C07F9/091 , C07F9/301 , C07F9/3808 , C07F9/3826 , C07F9/4006 , C07F9/653 , C07F9/65515 , C07F9/655345
Abstract: The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutics for treating medical conditions associated with agonism or antagonism of the individual receptors of the S1P receptor family.
Abstract translation: 本发明涉及作为S1P受体家族的一种或多种个体受体的激动剂或拮抗剂的新型，有效和选择性的药剂。 本发明的化合物可用作治疗剂，用于治疗与S1P受体家族的个体受体的激动或拮抗相关的医学病症。
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公开(公告)号：EP2109364A1
公开(公告)日：2009-10-21
申请号：EP07867755.6
申请日：2007-12-14
Applicant: ABBOTT LABORATORIES
Inventor： HOBSON, Adrian D. , FIX-STENZEL, Shannon , CUSACK, Kevin P. , BREINLINGER, Eric C. , ANSELL, Graham K. , STOFFEL, Robert H. , WOLLER, Kevin, R. , GRONGSAARD, Pintipa
CPC classification number: C07D271/07 , C07D271/06 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.
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公开(公告)号：EP2139329A1
公开(公告)日：2010-01-06
申请号：EP08742312.5
申请日：2008-03-27
Applicant: ABBOTT LABORATORIES
Inventor： CALDERWOOD, David J. , FRANK, Kristine E. , BETSCHMANN, Patrick , BREINLINGER, Eric C. , DIXON, Richard W.
IPC: A01N43/58 , A61K31/50 , C07D471/00
CPC classification number: C07D487/04
Abstract: The present invention is directed to novel imidazopyrazine compounds useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
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