公开(公告)号：WO2011068899A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/058598

申请日：2010-12-01

Applicant: ABBOTT LABORATORIES ,  WISHART, Neil ,  ARGIRIADI, Maria A. ,  BREINLINGER, Eric C. ,  CALDERWOOD, David J. ,  ERICSSON, Anna M. ,  FIAMENGO, Bryan A. ,  FRANK, Kristine E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn M. ,  GOEDKEN, Eric R. ,  JOSEPHSOHN, Nathan S. ,  LI, Biqin C. ,  MORYTKO, Michael J. ,  MULLEN, Kelly D. ,  SOMAL, Gagandeep ,  STEWART, Kent D. ,  VOSS, Jeffrey W. ,  WALLACE, Grier A. ,  WANG, Lu ,  WOLLER, Kevin R.

Inventor： WISHART, Neil ,  ARGIRIADI, Maria A. ,  BREINLINGER, Eric C. ,  CALDERWOOD, David J. ,  ERICSSON, Anna M. ,  FIAMENGO, Bryan A. ,  FRANK, Kristine E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn M. ,  GOEDKEN, Eric R. ,  JOSEPHSOHN, Nathan S. ,  LI, Biqin C. ,  MORYTKO, Michael J. ,  MULLEN, Kelly D. ,  SOMAL, Gagandeep ,  STEWART, Kent D. ,  VOSS, Jeffrey W. ,  WALLACE, Grier A. ,  WANG, Lu ,  WOLLER, Kevin R.

IPC: A01N43/42 ,  A61K31/44

CPC classification number: C07F9/06 ,  C07D471/14 ,  C07D487/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides a compound of Formula (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), or (Il) as defined herein, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供了式（Ia），（Ib），（Ic），（Id），（Ie），（If），（Ig），（Ih），（Ii），（Ij），（Ik） ，或（II），其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：WO2005110410A2

公开(公告)日：2005-11-24

申请号：PCT/US2005/016903

申请日：2005-05-13

Applicant: ABBOTT LABORATORIES ,  CUSACK, Kevin ,  SALMERON-GARCIA, Jose-Andres ,  GORDON, Thomas D. ,  BARBERIS, Claude E. ,  ALLEN, Hamish J. ,  BISCHOFF, Agniezka K. ,  ERICSSON, Anna M. ,  FRIEDMAN, Michael M. ,  GEORGE, Dawn M. ,  ROTH, Gregory P. ,  TALANIAN, Robert V. ,  THOMAS, Christine ,  WALLACE, Grier A. ,  WISHART, Neil ,  YU, Zhengtian

Inventor： CUSACK, Kevin ,  SALMERON-GARCIA, Jose-Andres ,  GORDON, Thomas D. ,  BARBERIS, Claude E. ,  ALLEN, Hamish J. ,  BISCHOFF, Agniezka K. ,  ERICSSON, Anna M. ,  FRIEDMAN, Michael M. ,  GEORGE, Dawn M. ,  ROTH, Gregory P. ,  TALANIAN, Robert V. ,  THOMAS, Christine ,  WALLACE, Grier A. ,  WISHART, Neil ,  YU, Zhengtian

IPC: A61K31/4743

CPC classification number: C07D471/04 ,  A61K31/4743 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  Y02A50/481

Abstract: A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Abstract translation: 式（I）的化合物或其药学上可接受的盐，其中取代基如本文所定义，其可用作激酶抑制剂。

公开(公告)号：WO2008079382A1

公开(公告)日：2008-07-03

申请号：PCT/US2007/026263

申请日：2007-12-21

Applicant: ABBOTT LABORATORIES ,  WALLACE, Grier A. ,  BREINLINGER, Eric C. ,  CUSACK, Kevin P. ,  FIX-STENZEL, Shannon R. ,  GORDON, Thomas D. ,  HOBSON, Adrian D. ,  HAYES, Martin E. ,  ANSELL, Graham K. ,  GRONGSAARD, Pintipa

Inventor： WALLACE, Grier A. ,  BREINLINGER, Eric C. ,  CUSACK, Kevin P. ,  FIX-STENZEL, Shannon R. ,  GORDON, Thomas D. ,  HOBSON, Adrian D. ,  HAYES, Martin E. ,  ANSELL, Graham K. ,  GRONGSAARD, Pintipa

IPC: A01N43/50 ,  A61K31/415

CPC classification number: C07D413/04 ,  C07C215/38 ,  C07C215/42 ,  C07C217/52 ,  C07C217/74 ,  C07C229/14 ,  C07C229/48 ,  C07C2601/02 ,  C07C2601/08 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D213/30 ,  C07D263/32 ,  C07D263/52 ,  C07D271/06 ,  C07D307/22 ,  C07D307/24 ,  C07D333/16 ,  C07D491/107 ,  C07F9/091 ,  C07F9/301 ,  C07F9/3808 ,  C07F9/3826 ,  C07F9/4006 ,  C07F9/653 ,  C07F9/65515 ,  C07F9/655345

Abstract: The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutics for treating medical conditions associated with agonism or antagonism of the individual receptors of the S1P receptor family.

Abstract translation: 本发明涉及作为S1P受体家族的一种或多种单独受体的激动剂或拮抗剂的新颖的，有效的和选择性的药剂。 本发明的化合物可用作治疗与S1P受体家族的各个受体的激动作用或拮抗作用相关的医学病症的治疗剂。

公开(公告)号：WO2007084728A3

公开(公告)日：2007-07-26

申请号：PCT/US2007/001548

申请日：2007-01-19

Applicant: ABBOTT LABORATORIES ,  ROTH, Gregory P. ,  WALLACE, Grier A. ,  GEORGE, Dawn M. ,  GRONGSAARD, Pintipa ,  HAYES, Martin ,  BREINLINGER, Eric C.

Inventor： ROTH, Gregory P. ,  WALLACE, Grier A. ,  GEORGE, Dawn M. ,  GRONGSAARD, Pintipa ,  HAYES, Martin ,  BREINLINGER, Eric C.

IPC: A61K31/496

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I), wherein the substituents are as defined herein, which are useful as therapeutic agents.

公开(公告)号：EP1753428A2

公开(公告)日：2007-02-21

申请号：EP05778736.8

申请日：2005-05-13

Applicant: ABBOTT LABORATORIES

Inventor： CUSACK, Kevin ,  SALMERON-GARCIA, Jose-Andres ,  GORDON, Thomas D. ,  BARBERIS, Claude E. ,  ALLEN, Hamish J. ,  BISCHOFF, Agnieszka K. ,  ERICSSON, Anna M. ,  FRIEDMAN, Michael M. ,  GEORGE, Dawn M. ,  ROTH, Gregory P. ,  TALANIAN, Robert V. ,  THOMAS, Christine ,  WALLACE, Grier A. ,  WISHART, Neil ,  YU, Zhengtian

IPC: A61K31/4743 ,  C07D498/02

CPC classification number: C07D471/04 ,  A61K31/4743 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  Y02A50/481

Abstract: A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

公开(公告)号：EP1983992A2

公开(公告)日：2008-10-29

申请号：EP07717989.3

申请日：2007-01-19

Applicant: ABBOTT LABORATORIES

Inventor： ROTH, Gregory P. ,  WALLACE, Grier A. ,  GEORGE, Dawn M. ,  GRONGSAARD, Pintipa ,  HAYES, Martin ,  BREINLINGER, Eric C.

IPC: A61K31/496

CPC classification number: C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I), wherein the substituents are as defined herein, which are useful as therapeutic agents.

公开(公告)号：EP2120575A1

公开(公告)日：2009-11-25

申请号：EP07863237.9

申请日：2007-12-21

Applicant: ABBOTT LABORATORIES

Inventor： WALLACE, Grier A. ,  BREINLINGER, Eric C. ,  CUSACK, Kevin P. ,  FIX-STENZEL, Shannon R. ,  GORDON, Thomas D. ,  HOBSON, Adrian D. ,  HAYES, Martin E. ,  ANSELL, Graham K. ,  GRONGSAARD, Pintipa

IPC: A01N43/50 ,  A61K31/415

CPC classification number: C07D413/04 ,  C07C215/38 ,  C07C215/42 ,  C07C217/52 ,  C07C217/74 ,  C07C229/14 ,  C07C229/48 ,  C07C2601/02 ,  C07C2601/08 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D213/30 ,  C07D263/32 ,  C07D263/52 ,  C07D271/06 ,  C07D307/22 ,  C07D307/24 ,  C07D333/16 ,  C07D491/107 ,  C07F9/091 ,  C07F9/301 ,  C07F9/3808 ,  C07F9/3826 ,  C07F9/4006 ,  C07F9/653 ,  C07F9/65515 ,  C07F9/655345

Abstract: The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutics for treating medical conditions associated with agonism or antagonism of the individual receptors of the S1P receptor family.

Abstract translation: 本发明涉及作为S1P受体家族的一种或多种个体受体的激动剂或拮抗剂的新型，有效和选择性的药剂。 本发明的化合物可用作治疗剂，用于治疗与S1P受体家族的个体受体的激动或拮抗相关的医学病症。

公开(公告)号：EP2102145A1

公开(公告)日：2009-09-23

申请号：EP07863231.2

申请日：2007-12-21

Applicant: ABBOTT LABORATORIES

Inventor： GORDON, Thomas D. ,  WALLACE, Grier A. ,  HAYES, Martin E. ,  LUKIN, Kirill A. ,  WANG, Lei ,  FERNANDO, Dilinie, P.

IPC: C07C69/74

CPC classification number: C07D235/02 ,  C07B2200/07 ,  C07C45/69 ,  C07C227/18 ,  C07C227/24 ,  C07C227/26 ,  C07C227/34 ,  C07C253/00 ,  C07C253/34 ,  C07C2601/08 ,  C07C49/697 ,  C07C49/753 ,  C07C229/48 ,  C07C255/46

Abstract: The present invention discloses processes for the preparation and isolation of the individual stereoisomers of 1-amino, 3-substituted phenylcyclopentane-carboxylates.

Abstract translation: 为1-氨基，3- substituiertem苯基环戊烷羧酸盐的单个立体异构体的制备和分离本发明的分类盘的过程。