公开(公告)号：WO2005075477A1

公开(公告)日：2005-08-18

申请号：PCT/US2004/040993

申请日：2004-12-08

Applicant: ABBOTT LABORATORIES ,  ANDERSON, David, A. ,  BEUTEL, Bruce, A. ,  COOPER, Curt, S. ,  GU, Yu-Gui ,  HINMAN, Mira, M. ,  KALVIN, Douglas, M. ,  KEYES, Robert, F. ,  SEARLE, Xenia, B. ,  WAGNER, Rolf

Inventor： ANDERSON, David, A. ,  BEUTEL, Bruce, A. ,  COOPER, Curt, S. ,  GU, Yu-Gui ,  HINMAN, Mira, M. ,  KALVIN, Douglas, M. ,  KEYES, Robert, F. ,  SEARLE, Xenia, B. ,  WAGNER, Rolf

IPC: C07D471/04

CPC classification number: C07D513/04 ,  C07D207/12 ,  C07D207/16 ,  C07D239/48 ,  C07D277/36 ,  C07D471/04

Abstract: Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.

Abstract translation: 公开了具有式（I）的具有式（I）的细菌蛋白质合成抑制化合物及其前体药物的前体药物，其制备方法，含该化合物的组合物，使用该化合物的方法。

公开(公告)号：WO2004083207A1

公开(公告)日：2004-09-30

申请号：PCT/US2003/007689

申请日：2003-03-12

Applicant: ABBOTT LABORATORIES

Inventor： ANDERSON, David ,  BEUTEL, Bruce ,  BOSSE, Todd, D. ,  CLARK, Richard ,  COOPER, Curt ,  DANDLIKER, Peter ,  DAVID, Caroline ,  GU, Yu-Gui ,  HANSEN, Todd, Matthew ,  HINMAN, Mira ,  KALVIN, Douglas ,  LARSON, Daniel, P. ,  LYNCH, Linda ,  MA, Zhenkun ,  MOTTER, Christopher ,  PALAZZO, Fabio ,  ROSENBERG, Teresa ,  REHM, Tamara ,  SANDERS, William ,  TUFANO, Michael ,  WAGNER, Rolf ,  WEITZBERG, Moshe ,  YONG, Hong ,  ZHANG, Tianyuan

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Antibacterials having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.

Abstract translation: 公开了具有式（I）的抗菌剂及其前体药物的盐，前药和盐，用于制备本方法中使用的化合物和中间体的方法，含该化合物的组合物，以及使用该化合物预防和治疗细菌感染的方法。

公开(公告)号：EP0979230A1

公开(公告)日：2000-02-16

申请号：EP98917950.2

申请日：1998-04-16

Applicant: Abbott Laboratories

Inventor： BHAGWAT, Shripad, S. ,  LEE, Chih-Hung ,  PERNER, Richard, J. ,  GU, Yu-Gui

IPC: C07D471/04 ,  A61K31/505

CPC classification number: C07D471/04

Abstract: A compound having formula (I), wherein R?1, R2, R3 and R4¿ are defined variables selected from the groups as specified herein which include alkyl, aryl, heteroaryl and heterocyclic and substituted versions thereof, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, nociperception, pain, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods of preparation thereof.

公开(公告)号：EP1631570A1

公开(公告)日：2006-03-08

申请号：EP03723732.8

申请日：2003-03-12

Applicant: ABBOTT LABORATORIES

Inventor： ANDERSON, David ,  BEUTEL, Bruce ,  BOSSE, Todd, D. ,  CLARK, Richard ,  COOPER, Curt ,  DANDLIKER, Peter ,  DAVID, Caroline ,  GU, Yu-Gui ,  HANSEN, Todd, Matthew ,  HINMAN, Mira ,  KALVIN, Douglas ,  LARSON, Daniel, P. ,  LYNCH, Linda ,  MA, Zhenkun ,  MOTTER, Christopher ,  PALAZZO, Fabio ,  ROSENBERG, Teresa ,  REHM, Tamara ,  SANDERS, William ,  TUFANO, Michael ,  WAGNER, Rolf ,  WEITZBERG, Moshe ,  YONG, Hong ,  ZHANG, Tianyuan

IPC: C07D471/04 ,  A61K31/435 ,  A61P31/04

CPC classification number: C07D471/04

Abstract: Antibacterials having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：EP1087938A1

公开(公告)日：2001-04-04

申请号：EP99918495.5

申请日：1999-04-12

Applicant: ABBOTT LABORATORIES

Inventor： MARING, Clarence, J. ,  GU, Yu-Gui ,  CHEN, Yuanwei ,  DEGOEY, David, A. ,  GIRANDA, Vincent, L. ,  GRAMPOVNIK, David, J. ,  KATI, Warren, M. ,  KEMPF, Dale, J. ,  KENNEDY, April ,  LIN, Zhen ,  MADIGAN, Darold, L. ,  MUCHMORE, Steven, W. ,  SHAM, Hing, L. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  SUN, Minghua ,  WANG, Gary, T. ,  WANG, Sheldon ,  YEUNG, Ming, C.

IPC: C07C271/24 ,  C07C233/52 ,  C07C233/47 ,  C07C271/22 ,  C07D233/54 ,  C07D263/32 ,  A61K31/33 ,  A61K31/16 ,  C07C237/24 ,  C07D307/24 ,  C07D405/04

CPC classification number: C07D233/64 ,  C07C233/52 ,  C07C237/24 ,  C07C271/24 ,  C07C2601/08 ,  C07D307/24 ,  C07D317/32 ,  C07D493/08

Abstract: Disclosed are compounds of formula (I), (II) or (III), which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

Abstract translation: 公开了式（I），（II）或（III）的化合物，其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。