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公开(公告)号：WO2016161402A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025787
申请日：2016-04-02
Applicant: ABBOTT LABORATORIES
Inventor： HUFF, Jeffrey B. , HAYDEN, Mark A. , KARABATSOS, Peter J. , SCHAPALS, Andrew S. , MUERHOFF, Anthony S. , BOGDAN, Felicia , LEARY, Thomas , HOLETS-MCCORMACK, Shelley R. , LAURENSON, Sophie , FISCHER, Andrew T. , HAACK, Richard , HERSHBERGER, Stefan , HOUSE, Dustin , QIAO, Lei , MURPHY, M. Shawn , POPE, Mark R. , PRIETO-BALLENGEE, Edna M. , RUAN, QiaoQiao , SONI, Pathik , TETIN, Sergey , YARNELL, Lyle
IPC: G01N33/53 , G01N33/487 , G01N33/543
CPC classification number: G01N33/48721 , B01L3/502761 , B01L2300/0645 , B01L2400/0406 , G01N33/5308 , G01N33/54306 , G01N2458/10
Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.
Abstract translation: 公开了使用纳米孔分析物分析的方法，装置和系统。 方法，装置和系统利用第一和第二结合成员，每个结合成员都特异性结合生物样品中的分析物。 该方法还包括检测和/或计数连接到第二结合成员的可切割标签，并将标签的存在和/或数量与分析物的存在和/或浓度相关联。 方法的某些方面不涉及标签，而是可以直接检测/量化第二结合成员。 检测和/或计数可以通过将标签/第二结合部件移位通过纳米孔来进行。 还提供了被编程以执行所公开的方法的设备和系统。
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公开(公告)号：WO2016161400A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025785
申请日：2016-04-02
Applicant: ABBOTT LABORATORIES
Inventor： HUFF, Jeffrey B. , HAYDEN, Mark A. , KARABATSOS, Peter J. , FISCHER, Andrew (Andy) , ROBINSON, John M. , HOLETS-MCCORMACK, Shelley R. , LAURENSON, Sophie
CPC classification number: B01L3/502784 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2200/0689 , B01L2200/10 , B01L2200/142 , B01L2300/0829 , B01L2300/0858 , B01L2300/0887 , B01L2300/089 , B01L2300/0893 , B01L2300/12 , B01L2300/161 , G01N33/5302 , G01N33/54373
Abstract: Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells.
Abstract translation: 公开了包括与检测组件集成的样品制备组件的集成器件。 样品制备组件可以是数字微流体模块或表面声波模块，该模块用于将样品液滴与试剂液滴组合，并且用于进行另外的样品制备步骤，导致含有指示存在的珠粒/颗粒/标记的液滴 或不存在样品中感兴趣的分析物。 可以通过将液滴移动到装置的检测部件来检测珠/颗粒/标签，该检测部件包括一组孔。
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公开(公告)号：WO2018053174A1
公开(公告)日：2018-03-22
申请号：PCT/US2017/051627
申请日：2017-09-14
Applicant: ABBOTT LABORATORIES
Inventor： LAURENSON, Sophie , HAYDEN, Mark A. , HUFF, Jeffrey B. , FISCHER, Andrew , ROBINSON, John , HOLETS-MCCORMACK, Shelley R.
Abstract: Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells. The detection modules disclosed here can be used for detecting analytes of interest which analytes may have been enriched by amplification, isolation, or other techniques.
Abstract translation: 公开了包括与检测组件集成的样品制备组件的集成装置。 样品制备部件可以是数字微流体模块或表面声波模块，其中模块用于将样品液滴与试剂液滴结合并用于执行附加的样品制备步骤，从而导致包含指示存在的珠子/颗粒/标签的液滴 或样品中没有感兴趣的分析物。 可以通过将液滴移动到装置的检测部件来检测珠/颗粒/标签，该检测部件包括一列孔。 这里公开的检测模块可用于检测分析物可能已通过扩增，分离或其他技术富集的感兴趣分析物。
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公开(公告)号：WO2017004463A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/040579
申请日：2016-06-30
Applicant: ABBOTT LABORATORIES
Inventor： HUFF, Jeffrey B. , HAYDEN, Mark A. , KARABATSOS, Peter J. , SCHAPALS, Andrew S. , MUERHOFF, Anthony S. , BOGDAN, Maria Felicia , LEARY, Thomas , HOLETS-MCCORMACK, Shelley R. , LAURENSON, Sophie , FISCHER, Andrew T. , HAACK, Richard , HERSHBERGER, Stefan , HOUSE, Dustin , QIAO, Lei , MURPHY, M. Shawn , POPE, Mark R. , PRIETO-BALLENGEE, Edna M. , RUAN, QiaoQiao , SONI, Pathik , TETIN, Sergey , YARNELL, Lyle
IPC: G01N33/53 , G01N33/487 , G01N33/543
CPC classification number: G01N33/54306 , G01N33/48721 , G01N33/5308 , G01N2458/10
Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. Other aspects of the methods use a phage conjugate as the detection moiety. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.
Abstract translation: 公开了使用纳米孔分析物分析的方法，装置和系统。 方法，装置和系统利用第一和第二结合成员，每个结合成员都特异性结合生物样品中的分析物。 该方法还包括检测和/或计数连接到第二结合成员的可切割标签，并将标签的存在和/或数量与分析物的存在和/或浓度相关联。 方法的某些方面不涉及标签，而是可以直接检测/量化第二结合成员。 方法的其他方面使用噬菌体缀合物作为检测部分。 检测和/或计数可以通过将标签/第二结合部件移位通过纳米孔来进行。 还提供了被编程以执行所公开的方法的设备和系统。
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Patent Agency Ranking
公开(公告)号：EP3277427A1
公开(公告)日：2018-02-07
申请号：EP16718557.8
申请日：2016-04-02
Applicant: Abbott Laboratories
Inventor： HUFF, Jeffrey B. , HAYDEN, Mark A. , KARABATSOS, Peter J. , FISCHER, Andrew (Andy) , ROBINSON, John M. , HOLETS-MCCORMACK, Shelley R. , LAURENSON, Sophie
CPC classification number: B01L3/502784 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2200/0689 , B01L2200/10 , B01L2200/142 , B01L2300/0829 , B01L2300/0858 , B01L2300/0887 , B01L2300/089 , B01L2300/0893 , B01L2300/12 , B01L2300/161 , G01N33/5302 , G01N33/54373
Abstract: Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells.
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公开(公告)号：EP3278108A1
公开(公告)日：2018-02-07
申请号：EP16717521.5
申请日：2016-04-02
Applicant: Abbott Laboratories
Inventor： HUFF, Jeffrey B. , HAYDEN, Mark A. , KARABATSOS, Peter J. , SCHAPALS, Andrew S. , MUERHOFF, Anthony S. , BOGDAN, Felicia , LEARY, Thomas , HOLETS-MCCORMACK, Shelley R. , LAURENSON, Sophie , FISCHER, Andrew T. , HAACK, Richard , HERSHBERGER, Stefan , HOUSE, Dustin , QIAO, Lei , MURPHY, M. Shawn , POPE, Mark R. , PRIETO-BALLENGEE, Edna M. , RUAN, QiaoQiao , SONI, Pathik , TETIN, Sergey , YARNELL, Lyle
IPC: G01N33/53 , G01N33/487 , G01N33/543
CPC classification number: G01N33/48721 , B01L3/502761 , B01L2300/0645 , B01L2400/0406 , G01N33/5308 , G01N33/54306 , G01N2458/10
Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.
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公开(公告)号：EP4417691A3
公开(公告)日：2024-11-13
申请号：EP24172221.4
申请日：2017-09-14
Applicant: Abbott Laboratories
Inventor： LAURENSON, Sophie , HAYDEN, Mark A. , HUFF, Jeffrey B. , FISCHER, Andrew , ROBINSON, John , HOLETS-MCCORMACK, Shelley R.
IPC: C12Q1/6853 , C07H21/02 , C12N15/09
Abstract: Integrated devices (30; 40; 100; 101; 600); that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells. The detection modules disclosed here can be used for detecting analytes of interest which analytes may have been enriched by amplification, isolation, or other techniques.
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公开(公告)号：EP4417691A2
公开(公告)日：2024-08-21
申请号：EP24172221.4
申请日：2017-09-14
Applicant: Abbott Laboratories
Inventor： LAURENSON, Sophie , HAYDEN, Mark A. , HUFF, Jeffrey B. , FISCHER, Andrew , ROBINSON, John , HOLETS-MCCORMACK, Shelley R.
IPC: C12N15/09
CPC classification number: C12Q1/6853
Abstract: Integrated devices (30; 40; 100; 101; 600); that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells. The detection modules disclosed here can be used for detecting analytes of interest which analytes may have been enriched by amplification, isolation, or other techniques.
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公开(公告)号：EP3512862A1
公开(公告)日：2019-07-24
申请号：EP17851550.8
申请日：2017-09-14
Applicant: Abbott Laboratories
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