公开(公告)号：WO2002070507A2

公开(公告)日：2002-09-12

申请号：PCT/US2002/004541

申请日：2002-01-16

Applicant: ABBOTT LABORATORIES

Inventor： KYM, Philip, R. ,  LANE, Benjamin, C. ,  PRATT, John, K. ,  VON GELDERN, Tom ,  WINN, Martin ,  PATEL, Jyoti, R. ,  ARENDSEN, David, L. ,  AKRITOPOULOU-ZANZE, Irini ,  ASHWORTH, Kimba, L. ,  HARTANDI, Kresna ,  BRENNEMAN, Jehrod

IPC: C07D311/80

CPC classification number: C07D407/04 ,  C07D311/80 ,  C07D409/04

Abstract: Compounds of formula (I) are useful for treating type (II) diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 式（I）化合物可用于治疗II型糖尿病，肥胖症，高血糖症，葡萄糖清除不足，高胰岛素血症，高甘油三酯血症和高循环糖皮质激素水平，所述化合物的制剂，含有 化合物和使用这些化合物的治疗方法。

公开(公告)号：EP1208095B1

公开(公告)日：2004-05-12

申请号：EP00959835.0

申请日：2000-09-01

Applicant: Abbott Laboratories

Inventor： KYM, Philip, R. ,  LANE, Benjamin, C. ,  PRATT, John, K. ,  VON GELDERN, Tom

IPC: C07D311/80 ,  A61K31/352 ,  A61P3/10

CPC classification number: C07D311/80

Abstract: The instant invention relates to compounds of formula (I) which are useful as antagonists of the glucocorticoid receptor and for treating diabetes in a mammal. In addition, any glucocorticoid receptor antagonist(s) is useful for the treatment of diabetes.

公开(公告)号：EP1208095A1

公开(公告)日：2002-05-29

申请号：EP00959835.0

申请日：2000-09-01

Applicant: Abbott Laboratories

Inventor： KYM, Philip, R. ,  LANE, Benjamin, C. ,  PRATT, John, K. ,  VON GELDERN, Tom

IPC: C07D311/80 ,  A61K31/352 ,  A61P3/10

CPC classification number: C07D311/80

Abstract: The instant invention relates to compounds of formula (I) which are useful as antagonists of the glucocorticoid receptor and for treating diabetes in a mammal. In addition, any glucocorticoid receptor antagonist(s) is useful for the treatment of diabetes.