公开(公告)号：WO2020140071A1

公开(公告)日：2020-07-02

申请号：PCT/US2019/068801

申请日：2019-12-27

Applicant: ABBOTT LABORATORIES

Inventor： RUAN, Qiaoqiao ,  MACDONALD, Patrick J. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  CALFIN, Brenda ,  LIN, Zhen ,  HAACK, Richard ,  POPE, Mark R. ,  PROSTKO, John ,  QIU, Xiaoxing ,  BOGDAN, Felicia

IPC: G01N33/543 ,  G01N33/566 ,  G01N33/58

Abstract: The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a cross-linked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.

公开(公告)号：EP4375669A2

公开(公告)日：2024-05-29

申请号：EP24167359.9

申请日：2019-12-27

Applicant: Abbott Laboratories

Inventor： RUAN, Qiaoqiao ,  MACDONALD, Patrick J. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  CALFIN, Brenda ,  LIN, Zhen ,  HAACK, Richard ,  POPE, Mark R. ,  PROSTKO, John ,  QIU, Xiaoxing ,  BOGDAN, M. Felicia

IPC: G01N33/58

CPC classification number: G01N33/543 ,  G01N33/566 ,  G01N33/582

Abstract: The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a crosslinked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.

公开(公告)号：EP4375669A3

公开(公告)日：2024-07-24

申请号：EP24167359.9

申请日：2019-12-27

Applicant: Abbott Laboratories

Inventor： RUAN, Qiaoqiao ,  MACDONALD, Patrick J. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  CALFIN, Brenda ,  LIN, Zhen ,  HAACK, Richard ,  POPE, Mark R. ,  PROSTKO, John ,  QIU, Xiaoxing ,  BOGDAN, M. Felicia

IPC: G01N33/543 ,  G01N33/566 ,  G01N33/58

CPC classification number: G01N33/543 ,  G01N33/566 ,  G01N33/582

Abstract: The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a crosslinked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.

公开(公告)号：EP3903103A1

公开(公告)日：2021-11-03

申请号：EP19839791.1

申请日：2019-12-27

Applicant: Abbott Laboratories

Inventor： RUAN, Qiaoqiao ,  MACDONALD, Patrick J. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  CALFIN, Brenda ,  LIN, Zhen ,  HAACK, Richard ,  POPE, Mark R. ,  PROSTKO, John ,  QIU, Xiaoxing ,  BOGDAN, M. Felicia

IPC: G01N33/543 ,  G01N33/566 ,  G01N33/58