公开(公告)号：WO2020140071A1

公开(公告)日：2020-07-02

申请号：PCT/US2019/068801

申请日：2019-12-27

Applicant: ABBOTT LABORATORIES

Inventor： RUAN, Qiaoqiao ,  MACDONALD, Patrick J. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  CALFIN, Brenda ,  LIN, Zhen ,  HAACK, Richard ,  POPE, Mark R. ,  PROSTKO, John ,  QIU, Xiaoxing ,  BOGDAN, Felicia

IPC: G01N33/543 ,  G01N33/566 ,  G01N33/58

Abstract: The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a cross-linked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.

公开(公告)号：EP4375669A2

公开(公告)日：2024-05-29

申请号：EP24167359.9

申请日：2019-12-27

Applicant: Abbott Laboratories

Inventor： RUAN, Qiaoqiao ,  MACDONALD, Patrick J. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  CALFIN, Brenda ,  LIN, Zhen ,  HAACK, Richard ,  POPE, Mark R. ,  PROSTKO, John ,  QIU, Xiaoxing ,  BOGDAN, M. Felicia

IPC: G01N33/58

CPC classification number: G01N33/543 ,  G01N33/566 ,  G01N33/582

Abstract: The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a crosslinked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.

公开(公告)号：EP1087938A1

公开(公告)日：2001-04-04

申请号：EP99918495.5

申请日：1999-04-12

Applicant: ABBOTT LABORATORIES

Inventor： MARING, Clarence, J. ,  GU, Yu-Gui ,  CHEN, Yuanwei ,  DEGOEY, David, A. ,  GIRANDA, Vincent, L. ,  GRAMPOVNIK, David, J. ,  KATI, Warren, M. ,  KEMPF, Dale, J. ,  KENNEDY, April ,  LIN, Zhen ,  MADIGAN, Darold, L. ,  MUCHMORE, Steven, W. ,  SHAM, Hing, L. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  SUN, Minghua ,  WANG, Gary, T. ,  WANG, Sheldon ,  YEUNG, Ming, C.

IPC: C07C271/24 ,  C07C233/52 ,  C07C233/47 ,  C07C271/22 ,  C07D233/54 ,  C07D263/32 ,  A61K31/33 ,  A61K31/16 ,  C07C237/24 ,  C07D307/24 ,  C07D405/04

CPC classification number: C07D233/64 ,  C07C233/52 ,  C07C237/24 ,  C07C271/24 ,  C07C2601/08 ,  C07D307/24 ,  C07D317/32 ,  C07D493/08

Abstract: Disclosed are compounds of formula (I), (II) or (III), which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

Abstract translation: 公开了式（I），（II）或（III）的化合物，其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。

公开(公告)号：EP4375669A3

公开(公告)日：2024-07-24

申请号：EP24167359.9

申请日：2019-12-27

Applicant: Abbott Laboratories

Inventor： RUAN, Qiaoqiao ,  MACDONALD, Patrick J. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  CALFIN, Brenda ,  LIN, Zhen ,  HAACK, Richard ,  POPE, Mark R. ,  PROSTKO, John ,  QIU, Xiaoxing ,  BOGDAN, M. Felicia

IPC: G01N33/543 ,  G01N33/566 ,  G01N33/58

CPC classification number: G01N33/543 ,  G01N33/566 ,  G01N33/582

Abstract: The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a crosslinked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.

公开(公告)号：EP3903103A1

公开(公告)日：2021-11-03

申请号：EP19839791.1

申请日：2019-12-27

Applicant: Abbott Laboratories

Inventor： RUAN, Qiaoqiao ,  MACDONALD, Patrick J. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  CALFIN, Brenda ,  LIN, Zhen ,  HAACK, Richard ,  POPE, Mark R. ,  PROSTKO, John ,  QIU, Xiaoxing ,  BOGDAN, M. Felicia

IPC: G01N33/543 ,  G01N33/566 ,  G01N33/58

公开(公告)号：EP1358154A2

公开(公告)日：2003-11-05

申请号：EP00972042.6

申请日：2000-10-10

Applicant: Abbott Laboratories

Inventor： MARING, Clarence J. ,  GIRANDA, Vincent L. ,  KEMPF, Dale J. ,  STOLL, Vincent S. ,  SUN, Minghua ,  ZHAO, Chen ,  GU, Yu Gui ,  HANESSIAN, Stephen ,  WANG, Gary T. ,  KRUEGER, Allan C. ,  CHEN, Hui-Ju ,  CHEN, Yuanwei ,  DEGOEY, David A. ,  FLOSI, William J. ,  GRAMPOVNIK, David J. ,  KATI, Warren M. ,  KENNEDY, April L. ,  KLEIN, Larry L. ,  LIN, Zhen ,  MADIGAN, Darold L. ,  MCDANIEL, Keith F. ,  MUCHMORE, Steven W. ,  SHAM, Hing L. ,  STEWART, Kent D. ,  TU, Noah P. ,  WAGENAAR, Frank L. ,  WANG, Sheldon ,  WIEDEMAN, Paul E. ,  XU, Yibo ,  YEUNG, Ming C. ,  BAYRAKDARIAN, Malken ,  LUO, Xuehong

IPC: C07D207/16 ,  C07D403/04 ,  C07D417/04

CPC classification number: C07D207/16 ,  C07D207/26 ,  C07D207/327 ,  C07D207/38 ,  C07D207/46 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D303/16 ,  C07D403/04 ,  C07D405/04 ,  C07D405/06 ,  C07D409/06 ,  C07D413/04 ,  C07D417/04 ,  C07D417/06

Abstract: Enantiomerically enriched compounds having the absolute stereochemistry of the formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.