公开(公告)号：WO2021026403A1

公开(公告)日：2021-02-11

申请号：PCT/US2020/045297

申请日：2020-08-06

Applicant: ABBOTT LABORATORIES

Inventor： POPE, Mark R. ,  HERSHBERGER, Stefan J. ,  RUAN, Qiaoqiao ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  MACDONALD, Patrick ,  HAACK, Richard A.

IPC: G01N33/58

Abstract: The disclosure provides kits and methods for detecting a substance that interferes with detection of an analyte in a sample and for expanding the dynamic range and reducing the hook effect of an immunoassay. The kits and methods employ two conjugates with two different detectable labels, at least one of which is a chemiluminescent compound of Formula (I).

公开(公告)号：WO2021026402A1

公开(公告)日：2021-02-11

申请号：PCT/US2020/045296

申请日：2020-08-06

Applicant: ABBOTT LABORATORIES

Inventor： HERSHBERGER, Stefan J. ,  HAACK, Richard A. ,  RUAN, Qiaoqiao ,  BEST, Quinn ,  BAX, Brian M. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y.

IPC: C09B11/22 ,  C09B11/24 ,  C09B11/28 ,  C09B15/00 ,  C09B19/00 ,  C09B23/04 ,  C09B23/06 ,  C09B57/08 ,  C09B57/10 ,  C09K11/07 ,  G01N33/58

Abstract: Disclosed herein are compounds, conjugates, and methods that may be used to detect the presence of an analyte in a sample, such as a biological sample.

公开(公告)号：WO2020140071A1

公开(公告)日：2020-07-02

申请号：PCT/US2019/068801

申请日：2019-12-27

Applicant: ABBOTT LABORATORIES

Inventor： RUAN, Qiaoqiao ,  MACDONALD, Patrick J. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  CALFIN, Brenda ,  LIN, Zhen ,  HAACK, Richard ,  POPE, Mark R. ,  PROSTKO, John ,  QIU, Xiaoxing ,  BOGDAN, Felicia

IPC: G01N33/543 ,  G01N33/566 ,  G01N33/58

Abstract: The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a cross-linked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.

公开(公告)号：EP4375669A2

公开(公告)日：2024-05-29

申请号：EP24167359.9

申请日：2019-12-27

Applicant: Abbott Laboratories

Inventor： RUAN, Qiaoqiao ,  MACDONALD, Patrick J. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  CALFIN, Brenda ,  LIN, Zhen ,  HAACK, Richard ,  POPE, Mark R. ,  PROSTKO, John ,  QIU, Xiaoxing ,  BOGDAN, M. Felicia

IPC: G01N33/58

CPC classification number: G01N33/543 ,  G01N33/566 ,  G01N33/582

Abstract: The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a crosslinked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.

公开(公告)号：EP4375669A3

公开(公告)日：2024-07-24

申请号：EP24167359.9

申请日：2019-12-27

Applicant: Abbott Laboratories

Inventor： RUAN, Qiaoqiao ,  MACDONALD, Patrick J. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  CALFIN, Brenda ,  LIN, Zhen ,  HAACK, Richard ,  POPE, Mark R. ,  PROSTKO, John ,  QIU, Xiaoxing ,  BOGDAN, M. Felicia

IPC: G01N33/543 ,  G01N33/566 ,  G01N33/58

CPC classification number: G01N33/543 ,  G01N33/566 ,  G01N33/582

Abstract: The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a crosslinked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.

公开(公告)号：EP4010707A1

公开(公告)日：2022-06-15

申请号：EP20768731.0

申请日：2020-08-06

Applicant: Abbott Laboratories

Inventor： POPE, Mark R. ,  HERSHBERGER, Stefan J. ,  RUAN, Qiaoqiao ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  MACDONALD, Patrick ,  HAACK, Richard A.

IPC: G01N33/58

公开(公告)号：EP4010433A1

公开(公告)日：2022-06-15

申请号：EP20761032.0

申请日：2020-08-06

Applicant: Abbott Laboratories

Inventor： HERSHBERGER, Stefan J. ,  HAACK, Richard A. ,  RUAN, Qiaoqiao ,  BEST, Quinn ,  BAX, Brian M. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y.

IPC: C09B11/22 ,  C09B11/24 ,  C09B11/28 ,  C09B15/00 ,  C09B19/00 ,  C09B23/04 ,  C09B23/06 ,  C09B57/08 ,  C09B57/10 ,  C09K11/07 ,  G01N33/58

公开(公告)号：EP3903103A1

公开(公告)日：2021-11-03

申请号：EP19839791.1

申请日：2019-12-27

Applicant: Abbott Laboratories

Inventor： RUAN, Qiaoqiao ,  MACDONALD, Patrick J. ,  SWIFT, Kerry M. ,  TETIN, Sergey Y. ,  CALFIN, Brenda ,  LIN, Zhen ,  HAACK, Richard ,  POPE, Mark R. ,  PROSTKO, John ,  QIU, Xiaoxing ,  BOGDAN, M. Felicia

IPC: G01N33/543 ,  G01N33/566 ,  G01N33/58