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1.发明申请
公开(公告)号：WO2011119345A3
公开(公告)日：2011-09-29
申请号：PCT/US2011/027895
申请日：2011-03-10
Applicant: ABBOTT LABORATORIES , DING, Hong , ELMORE, Steven , HEXAMER, Laura , KUNZER, Aaron, R. , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard , WENDT, Michael
Inventor： DING, Hong , ELMORE, Steven , HEXAMER, Laura , KUNZER, Aaron, R. , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard , WENDT, Michael
IPC: C07D295/112 , C07D295/195 , C07D417/04 , C07D211/58 , C07C311/51 , A61K31/451 , A61K31/495 , A61K31/18 , A61P35/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti apoptotic Bcl-2 protein.
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公开(公告)号：WO2007140233A1
公开(公告)日：2007-12-06
申请号：PCT/US2007/069630
申请日：2007-05-24
Applicant: ABBOTT LABORATORIES , DIEBOLD, Robert B. , DJURIC, Stevan W. , GIRANDA, Vincent L , HEXAMER, Laura , LIN, Nan-horng , MIYASHIRO, Julie M. , PENNING, Thomas D. , PRZYTULINSKA, Magdalena , SOWIN, Thomas , SULLIVAN, Gerard , TAO, Zhi-fu , TONG, Yunsong , VASUDEVAN, Anil , WANG, Le , WOODS, Keith W. , XIA, Zhiren , ZHANG, Henry Q.
Inventor： DIEBOLD, Robert B. , DJURIC, Stevan W. , GIRANDA, Vincent L , HEXAMER, Laura , LIN, Nan-horng , MIYASHIRO, Julie M. , PENNING, Thomas D. , PRZYTULINSKA, Magdalena , SOWIN, Thomas , SULLIVAN, Gerard , TAO, Zhi-fu , TONG, Yunsong , VASUDEVAN, Anil , WANG, Le , WOODS, Keith W. , XIA, Zhiren , ZHANG, Henry Q.
IPC: C07C225/20 , C07D249/14 , C07D277/64 , C07D285/06 , C07D333/20 , A61P35/00 , A61K31/132 , A61K31/505
CPC classification number: C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
Abstract: Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
Abstract translation: 公开了抑制Plk1的化合物，含有该化合物的组合物和使用该化合物治疗疾病的方法。
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Patent Agency Ranking3.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开细胞凋亡诱导剂治疗癌症和免疫及自身免疫疾病
公开(公告)号：WO2010138588A2
公开(公告)日：2010-12-02
申请号：PCT/US2010/036198
申请日：2010-05-26
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D491/052 , C07D519/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白的疾病的方法。
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4.发明申请
公开(公告)号：WO2011150016A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/037849
申请日：2011-05-25
Applicant: ABBOTT LABORATORIES , TAO, Zhi-Fu , WANG, Xilu , SOUERS, Andrew J. , CATRON, Nathaniel D. , SULLIVAN, Gerard
Inventor： TAO, Zhi-Fu , WANG, Xilu , SOUERS, Andrew J. , CATRON, Nathaniel D. , SULLIVAN, Gerard
CPC classification number: C07D471/04 , A61K31/18 , A61K31/44 , A61K31/496 , A61P35/00 , C07F9/65616 , Y02A50/385 , Y02A50/401 , Y02A50/411 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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5.发明申请
公开(公告)号：WO2011149492A1
公开(公告)日：2011-12-01
申请号：PCT/US2010/057587
申请日：2010-11-22
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd, M.
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd, M.
IPC: C07D471/04 , A61K31/437 , A61K35/00
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：EP2021316A1
公开(公告)日：2009-02-11
申请号：EP07797725.4
申请日：2007-05-24
Applicant: ABBOTT LABORATORIES
Inventor： DIEBOLD, Robert B. , DJURIC, Stevan W. , GIRANDA, Vincent L , HEXAMER, Laura , LIN, Nan-horng , MIYASHIRO, Julie M. , PENNING, Thomas D. , PRZYTULINSKA, Magdalena , SOWIN, Thomas , SULLIVAN, Gerard , TAO, Zhi-fu , TONG, Yunsong , VASUDEVAN, Anil , WANG, Le , WOODS, Keith W. , XIA, Zhiren , ZHANG, Henry Q.
IPC: C07C225/20 , C07D249/14 , C07D277/64 , C07D285/06 , C07D333/20 , A61P35/00 , A61K31/132 , A61K31/505
CPC classification number: C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
Abstract: Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
Abstract translation: 其中X1，C1和D1在本文中定义的式（I）化合物是polo样激酶的抑制剂。 式（I）化合物可用于治疗细胞增殖疾病，例如癌症。
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7.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权细胞凋亡诱导剂用于癌症和免疫球蛋白和自身免疫性疾病的治疗
公开(公告)号：EP2435432A2
公开(公告)日：2012-04-04
申请号：EP10721246.6
申请日：2010-05-26
Applicant: Abbott Laboratories
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D491/052 , C07D519/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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