STEROL DERIVATIVE, VESICLE USING THE SAME AND THEIR PRODUCTION

    公开(公告)号:JPH10306062A

    公开(公告)日:1998-11-17

    申请号:JP11698797

    申请日:1997-05-07

    Abstract: PROBLEM TO BE SOLVED: To provide a novel sterol derivative that is useful for producing vesicles of good stability. SOLUTION: This compound is a sterol derivative represented by the formula (n is 4-8; R and R' are each a sterol having OH in the 3β-position), typically α,ω-bis(cholesteryloxycarbonly)hexaethylene-glycol. The sterol derivative of the formula is prepared by reaction of an oligoethylene glycol and a sterol halognoformate. When vesicles are produced, the sterol derivative of the formula is mixed with a cation, or with a phospholipid, or with a long-chain aliphatic amine or with a surfactant. The vesicles prepared from this cholesterol derivative can include a variety of hydrophilic substances.

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