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    1.
    发明专利
    未知

    公开(公告)号：DE3883777T2

    公开(公告)日：1994-01-27

    申请号：DE3883777

    申请日：1988-09-12

    Applicant: AGENCY IND SCIENCE TECHN ,  TERUMO CORP

    Inventor： MASUOKA TOSHIO ,  HIRASA OKIHIKO ,  ONISHI MAKOTO ,  SEITA YUKIO

    IPC: B01D63/08 ,  B01D67/00 ,  B01D69/00 ,  A61M1/16 ,  A61M1/34

    Abstract: A hydrophilic porous membrane having fine network structure and substantially comprising polypropylene is disclosed, which has on at least one side thereof a surface layer of about the same network structure as that of the inner portion, in which a hydrophilic polymer is chemically bonded to the membrane surface and fine pore surface, and which has an average pore size of 0.1 to 2.0 mu m, a bubble point of up to 2.0 kg/cm , voids of 60 to 85 %, and a water-penetrating amount of 2 ml/min.mmHg.m or more. This membrane is useful as a hydrophilic, plasma-separating membrane. A process for its production and a plasma-separating apparatus containing this membrane in a housing are also disclosed.

    2.
    发明专利
    未知

    公开(公告)号：DE3883777D1

    公开(公告)日：1993-10-07

    申请号：DE3883777

    申请日：1988-09-12

    Applicant: AGENCY IND SCIENCE TECHN ,  TERUMO CORP

    Inventor： MASUOKA TOSHIO ,  HIRASA OKIHIKO ,  ONISHI MAKOTO TERUMO KABUSHIKI ,  SEITA YUKIO TERUMO KABUSHIKI K

    IPC: B01D63/08 ,  B01D67/00 ,  B01D69/00 ,  A61M1/16 ,  A61M1/34

    Abstract: A hydrophilic porous membrane having fine network structure and substantially comprising polypropylene is disclosed, which has on at least one side thereof a surface layer of about the same network structure as that of the inner portion, in which a hydrophilic polymer is chemically bonded to the membrane surface and fine pore surface, and which has an average pore size of 0.1 to 2.0 mu m, a bubble point of up to 2.0 kg/cm , voids of 60 to 85 %, and a water-penetrating amount of 2 ml/min.mmHg.m or more. This membrane is useful as a hydrophilic, plasma-separating membrane. A process for its production and a plasma-separating apparatus containing this membrane in a housing are also disclosed.

    MEDICAL TREATMENT APPLIANCE COMPOSED OF POLYMER MATERIAL COATED WITH ANTITHROMBOTIC POLYSACCHARIDE
    10.
    发明专利
    MEDICAL TREATMENT APPLIANCE COMPOSED OF POLYMER MATERIAL COATED WITH ANTITHROMBOTIC POLYSACCHARIDE 失效

    公开(公告)号：JP2000279511A

    公开(公告)日：2000-10-10

    申请号：JP8754699

    申请日：1999-03-30

    Applicant: AGENCY IND SCIENCE TECHN ,  KYOCERA CORP

    Inventor： MASUOKA TOSHIO ,  JAN JOHANSON ,  MURAMATSU KAZUAKI ,  SHIMOTOSO TOSHIHIKO ,  FUJISAWA AKIRA

    IPC: A61L33/10

    Abstract: PROBLEM TO BE SOLVED: To improve the anticoagulation property by specifying the initial immobilization quantity on the surface part of an antithrombotic coating film in a substance polymerizing anion graft molecule on the surface of a polymer material and applying the antithrombotic polysaccharides on the graft layer via linker molecule. SOLUTION: After gaseous-phase graft polymerization of a polymer material being a base substance 1 of an assistant artificial heart with radical- polymerizable anionic monomer, a cation linker polymer 2 is connected on the anion graft matrix by an electrostatic interaction by multipoint contact. Secondly, the graft layer is coated with antithrombotic polysaccharides 4 via a linker molecule 3 composed of the cation polymer to form an antithrombotic coating film. In this case, the sulfur content S2p/C1s by XPS in the uppermost layer to be coated with the antithrombotic polysaccharides 4 is set to 0.040 or more and the initial immobilization quantity by the anti-factor Xa activity is set to 40×10-3 IU/cm2 or more.

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