公开(公告)号：DE3883777T2

公开(公告)日：1994-01-27

申请号：DE3883777

申请日：1988-09-12

Applicant: AGENCY IND SCIENCE TECHN ,  TERUMO CORP

Inventor： MASUOKA TOSHIO ,  HIRASA OKIHIKO ,  ONISHI MAKOTO ,  SEITA YUKIO

IPC: B01D63/08 ,  B01D67/00 ,  B01D69/00 ,  A61M1/16 ,  A61M1/34

Abstract: A hydrophilic porous membrane having fine network structure and substantially comprising polypropylene is disclosed, which has on at least one side thereof a surface layer of about the same network structure as that of the inner portion, in which a hydrophilic polymer is chemically bonded to the membrane surface and fine pore surface, and which has an average pore size of 0.1 to 2.0 mu m, a bubble point of up to 2.0 kg/cm , voids of 60 to 85 %, and a water-penetrating amount of 2 ml/min.mmHg.m or more. This membrane is useful as a hydrophilic, plasma-separating membrane. A process for its production and a plasma-separating apparatus containing this membrane in a housing are also disclosed.

公开(公告)号：DE3883777D1

公开(公告)日：1993-10-07

申请号：DE3883777

申请日：1988-09-12

Applicant: AGENCY IND SCIENCE TECHN ,  TERUMO CORP

Inventor： MASUOKA TOSHIO ,  HIRASA OKIHIKO ,  ONISHI MAKOTO TERUMO KABUSHIKI ,  SEITA YUKIO TERUMO KABUSHIKI K

IPC: B01D63/08 ,  B01D67/00 ,  B01D69/00 ,  A61M1/16 ,  A61M1/34

Abstract: A hydrophilic porous membrane having fine network structure and substantially comprising polypropylene is disclosed, which has on at least one side thereof a surface layer of about the same network structure as that of the inner portion, in which a hydrophilic polymer is chemically bonded to the membrane surface and fine pore surface, and which has an average pore size of 0.1 to 2.0 mu m, a bubble point of up to 2.0 kg/cm , voids of 60 to 85 %, and a water-penetrating amount of 2 ml/min.mmHg.m or more. This membrane is useful as a hydrophilic, plasma-separating membrane. A process for its production and a plasma-separating apparatus containing this membrane in a housing are also disclosed.

公开(公告)号：DE3769011D1

公开(公告)日：1991-05-08

申请号：DE3769011

申请日：1987-05-07

Applicant: AGENCY IND SCIENCE TECHN ,  TERUMO CORP

Inventor： MASUOKA TOSHIO ,  HIRASA OKIHIKO ,  SUDA YOSHIO ,  ONISHI MAKOTO ,  SEITA YUKIO

IPC: A61M1/22 ,  A61M1/16 ,  B01D63/08 ,  B01D67/00 ,  B01D71/82 ,  D06M13/02 ,  D06M13/224 ,  D06M13/322 ,  D06M13/402 ,  D06M13/41 ,  D06M14/00 ,  D06M101/00 ,  D06M101/16 ,  D06M101/18 ,  B01D71/00

Abstract: A hydrophilic porous membrane having graft chains of a hydrophilic monomer formed on the surface of a hydrophobic porous membrane so as to impart to the surface perfect hydrophilicity such that the produced membrane, when wetted, exhibits as swelling ratio of not more than 1% and a bubble point in the range of 0.5 to 8 kg/cm . The hydrophilic porous membrane is produced by irradiating the hydrophobic porous membrane with plasma, feeding the hydrophilic monomer in a gaseous state, and allowing the hydrophilic monomer to be graft polymerized on the surface of the porous membrane. A plasma separator is obtained by using the aforementioned hydrophilic porous membrane as a plasma separation membrane.

公开(公告)号：AU7257587A

公开(公告)日：1987-12-10

申请号：AU7257587

申请日：1987-05-05

Applicant: AGENCY IND SCIENCE TECHN ,  TERUMO CORP

Inventor： MASUOKA TOSHIO ,  SUDA YOSHIO ,  SEITA YUKIO ,  HIRASA OKIHIKO ,  ONISHI MAKOTO

IPC: C08J7/18 ,  B01D13/04 ,  B01D13/00

公开(公告)号：CA1325405C

公开(公告)日：1993-12-21

申请号：CA577109

申请日：1988-09-12

Applicant: AGENCY IND SCIENCE TECHN ,  TERUMO CORP

Inventor： MASUOKA TOSHIO ,  HIRASA OKIHIKO ,  ONISHI MAKOTO ,  SEITA YUKIO

IPC: B01D63/08 ,  B01D67/00 ,  B01D69/12 ,  A61M1/34

Abstract: A porous hydrophilic polypropylene membrane possessing a fine reticular structure, which is characterized by the fact that at least either of the opposite surfaces of membrane forms a surface layer of a reticular structure substantially equal to that in the interior of membrane, the membrane surfaces and the surfaces of pores in the membrane have a hydrophilic polymer chemically bonded thereto, and the membrane is composed substantially of a polypropylene possessing an average pore diameter in the range 0.1 to 2.0 .mu.m, a bubble point of not more than 2.0 kg/cm2, a porosity in the range of 60 to 85%, and a water permeability of not less than 2 ml/min.mmHg.m2, a method for the production thereof, and a blood plasma separation apparatus incorporating such membranes in a housing are disclosed.

公开(公告)号：CA1313441C

公开(公告)日：1993-02-09

申请号：CA536428

申请日：1987-05-05

Applicant: AGENCY IND SCIENCE TECHN ,  TERUMO CORP

Inventor： MASUOKA TOSHIO ,  HIRASA OKIHIKO ,  SUDA YOSHIO ,  ONISHI MAKOTO ,  SEITA YUKIO

IPC: A61M1/22 ,  A61M1/16 ,  B01D63/08 ,  B01D67/00 ,  B01D71/82 ,  D06M13/02 ,  D06M13/224 ,  D06M13/322 ,  D06M13/402 ,  D06M13/41 ,  D06M14/00 ,  D06M101/00 ,  D06M101/16 ,  D06M101/18 ,  C08J5/22

Abstract: A hydrophilic porous membrane has graft chains of a hydrophilic monomer formed on the surface of a hydrophobic porous membrane so as to impart to the surface perfect hydrophilicity such that the produced membrane, when wetted, exhibits a swelling ratio of not more than 1% and a bubble point in the range of 0.5 to 8 kg/cm2. The hydrophilic porous membrane is produced by irradiating the hydrophobic porous membrane with plasma, feeding the hydrophilic monomer in a gaseous state, and allowing the hydrophilic monomer to be graft polymerized on the surface of the porous membrane. A plasma separator is obtained by using the aforementioned hydrophilic porous membrane as a plasma separation membrane.

公开(公告)号：JPS62149716A

公开(公告)日：1987-07-03

申请号：JP29068485

申请日：1985-12-25

Applicant: AGENCY IND SCIENCE TECHN ,  TERUMO CORP

Inventor： MASUOKA TOSHIO ,  HIRASA OKIHIKO ,  SUDA MASAO ,  EMI MASATO

IPC: D01F6/06 ,  C08F220/56 ,  C08F255/02 ,  C08F291/00 ,  C08J7/16 ,  D06M10/00 ,  D06M13/02 ,  D06M13/322 ,  D06M13/402 ,  D06M13/41 ,  D06M14/08 ,  D06M14/10 ,  D06M101/00 ,  D06M101/16 ,  D06M101/18 ,  D06M101/20 ,  D06M101/22 ,  D06M101/26

Abstract: PURPOSE:To obtain a water-absorptive polymer in the form of a composite of a porous base with a graft polymer layer, by irradiating a porous base comprising a crystalline polymer with a plasma and graft-polymerizing a water-soluble monomer with the base. CONSTITUTION:This water-absorptive polymer is obtained by irradiating a porous base comprising a crystalline polymer with a plasma, impregnating this base with at least one unsaturated monomer containing at least one N,N- disubstituted (meth)acrylamide of the formula (wherein R and R are each H or a 1-4C alkyl provided that R and R can not be H at the same time, and R is H or methyl] and graft-polymerizing the monomer. The obtained water-absorptive polymer is one in which the graft polymer layer of said unsaturated monomer is formed as a uniform polymer layer formed by disintegrating the crystalline region of the porous crystalline polymer as the base. A desinable crystalline polymer which constitutes the base is polypropylene.

公开(公告)号：JPS62262705A

公开(公告)日：1987-11-14

申请号：JP10301186

申请日：1986-05-07

Applicant: AGENCY IND SCIENCE TECHN ,  TERUMO CORP

Inventor： MASUOKA TOSHIO ,  HIRASA OKIHIKO ,  SUDA MASAO ,  ONISHI MASATO ,  KIYOTA YUKIO

IPC: A61M1/22 ,  A61M1/16 ,  B01D63/08 ,  B01D67/00 ,  B01D71/82 ,  D06M13/02 ,  D06M13/224 ,  D06M13/322 ,  D06M13/402 ,  D06M13/41 ,  D06M14/00 ,  D06M101/00 ,  D06M101/16 ,  D06M101/18

Abstract: PURPOSE:To obtain the title hydrophilic porous serum separation membrane having excellent physical properties such as dimensional stability and strength and with less deterioration in the membrane performance by graft-polymerizing a hydrophobic monomer on the outer surface of a hydrophobic porous membrane to make the membrane hydrophilic. CONSTITUTION:The surface of the hydrophobic membrane is treated with plasma and activated, and the hydrophilic monomer is graft-polymerized on the surface to make the membrane hydrophilic. Nitrogen, hydrogen, argon, etc., are introduced at 10 -10Torr, 0.1-300W power is impressed by a high-frequency oscillator to generate plasma, and the hydrophobic membrane is irradiated with the plasma for 1-60sec. Then the gaseous hydrophilic monomer is supplied under the absence of plasma, and the graft polymerization is carried out. The graft polymerization is carried out at 0-80 deg.C and 10 -10 Torr, and finished in 10sec-60min. The rate of the graft polymerization is preferably controlled to 2-30%. The bubble point of the obtained membrane is adjusted to 0.5-8kg/cm , and the degree of swelling is controlled to

公开(公告)号：AU580212B2

公开(公告)日：1989-01-05

申请号：AU7257587

申请日：1987-05-05

Applicant: AGENCY IND SCIENCE TECHN

Inventor： MASUOKA TOSHIO ,  SUDA MASAO ,  SEITA YUKIO ,  HIRASA OKIHIKO ,  ONISHI MAKOTO

IPC: C08J7/18 ,  B01D13/04 ,  B01D13/00

公开(公告)号：AU611950B2

公开(公告)日：1991-06-27

申请号：AU2306388

申请日：1988-09-12

Applicant: AGENCY IND SCIENCE TECHN

Inventor： MASUOKA TOSHIO ,  HIRASA OKIHIKO ,  ONISHI MAKOTO ,  SEITA YUKIO

IPC: B01D63/08 ,  B01D67/00 ,  B01D61/00 ,  B01D71/26 ,  A61K35/14

Abstract: A hydrophilic porous membrane having fine network structure and substantially comprising polypropylene is disclosed, which has on at least one side thereof a surface layer of about the same network structure as that of the inner portion, in which a hydrophilic polymer is chemically bonded to the membrane surface and fine pore surface, and which has an average pore size of 0.1 to 2.0 mu m, a bubble point of up to 2.0 kg/cm , voids of 60 to 85 %, and a water-penetrating amount of 2 ml/min.mmHg.m or more. This membrane is useful as a hydrophilic, plasma-separating membrane. A process for its production and a plasma-separating apparatus containing this membrane in a housing are also disclosed.