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公开(公告)号：CA2561280A1
公开(公告)日：2005-10-20
申请号：CA2561280
申请日：2005-03-29
Applicant: AVENTIS PHARMA INC
Inventor： WEINTRAUB PHILIP M , MEHDI SHUJAATH , PEUKERT STEFAN , EASTWOOD PAUL R , STEFANY DAVID W , LIM SUNGTAEK , SCHWAHN UWE , MOORCROFT NEIL , MUSICK KWON YON , JIANG JOHN Z , RUTTEN HARTMUT
IPC: C07D213/62 , A61K31/44 , A61P9/00 , A61P9/10 , A61P19/02 , A61P25/28 , A61P29/00 , C07D213/64 , C07D217/24 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/14
Abstract: The present invention discloses and claims a series of 2,3,5-substituted pyridone derivatives as defined herein. This invention also relates to metho ds of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5'-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or preventi on of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
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公开(公告)号：HU0302485A2
公开(公告)日：2003-12-29
申请号：HU0302485
申请日：2001-04-27
Applicant: AVENTIS PHARMA INC
Inventor： ASTLES PETER C , CZEKAJ MARK , EASTWOOD PAUL R , GONG YONG , HOUILLE OLIVIER , LEVELL JULIAN , LIANG GUYAN , NEUENSCHWANDER KENT , PAULS HEINZ , PRIBISH JAMES
IPC: A61K31/451 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K45/00 , A61P1/02 , A61P1/16 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/06 , A61P19/06 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D211/26 , C07D211/32 , C07D211/58 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D411/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
Abstract: Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration of an inhibitor of tryptase, e.g., asthma and inflammatory diseases, to name only a few.
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公开(公告)号：NO20025601A
公开(公告)日：2003-01-06
申请号：NO20025601
申请日：2002-11-21
Applicant: AVENTIS PHARMA INC
Inventor： ASTLES PETER C , EASTWOOD PAUL R , HOUILLE OLIVIER , LEVELL JULIAN , PAULS HEINZ , CZEKAJ MARK , LIANG GUYAN , GONG YONG , PRIBISH JAMES , NEUENSCHWANDER KENT
IPC: A61K31/451 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K45/00 , A61P1/02 , A61P1/16 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/06 , A61P19/06 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D211/26 , C07D211/32 , C07D211/58 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D411/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , A61K31/445 , A61P11/06 , C07D211/16
CPC classification number: C07D401/06 , C07D211/26 , C07D211/32 , C07D211/58 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D411/06 , C07D413/10 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
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公开(公告)号：MEP54608A
公开(公告)日：2011-05-10
申请号：MEP54608
申请日：2001-04-27
Applicant: AVENTIS PHARMA INC
Inventor： ASTLES PETER C , EASTWOOD PAUL R , HOUILLE OLIVIE , LEVELL JULIAN , PAULS HEINZ , CZEKAJ MARK , LIANG GUYAN , GONG YONG , PRIBISH JAMES , NEUENSCHWANDER KENT
IPC: A61K31/451 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K45/00 , A61P1/02 , A61P1/16 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/06 , A61P19/06 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D211/16 , C07D211/26 , C07D211/32 , C07D211/58 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D411/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
Abstract: Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration of an inhibitor of tryptase, e.g., asthma and inflammatory diseases, to name only a few.
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公开(公告)号：DK1296972T3
公开(公告)日：2010-04-26
申请号：DK01930925
申请日：2001-04-27
Applicant: AVENTIS PHARMA INC
Inventor： CZEKAJ MARK , ASTLES PETER C , EASTWOOD PAUL R , HOUILLE OLIVIER , LEVELL JULIAN , LIANG GUYAN , GONG YONG , PRIBISH JAMES , NEUENSCHWANDER KENT , PAULS HEINZ
IPC: C07D401/06 , A61K31/451 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K45/00 , A61P1/02 , A61P1/16 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/06 , A61P19/06 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D211/16 , C07D211/26 , C07D211/32 , C07D211/58 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D411/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
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Patent Agency Ranking
公开(公告)号：PT1296972E
公开(公告)日：2010-03-03
申请号：PT01930925
申请日：2001-04-27
Applicant: AVENTIS PHARMA INC
Inventor： ASTLES PETER C , EASTWOOD PAUL R , HOUILLE OLIVIER , LEVELL JULIAN , PAULS HEINZ , CZEKAJ MARK , LIANG GUYAN , GONG YONG , PRIBISH JAMES , NEUENSCHWANDER KENT
IPC: C07D401/06 , A61K31/451 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K45/00 , A61P1/02 , A61P1/16 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/06 , A61P19/06 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D211/16 , C07D211/26 , C07D211/32 , C07D211/58 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D411/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
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公开(公告)号：PL360495A1
公开(公告)日：2004-09-06
申请号：PL36049501
申请日：2001-04-27
Applicant: AVENTIS PHARMA INC
Inventor： ASTLES PETER C , EASTWOOD PAUL R , HOUILLE OLIVIER , LEVELL JULIAN , PAULS HEINZ , CZEKAJ MARK , LIANG GUYAN , GONG YONG , PRIBISH JAMES , NEUENSCHWANDER KENT
IPC: A61K31/451 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K45/00 , A61P1/02 , A61P1/16 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/06 , A61P19/06 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D211/26 , C07D211/32 , C07D211/58 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D411/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , C07D211/16
Abstract: Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration of an inhibitor of tryptase, e.g., asthma and inflammatory diseases, to name only a few.
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公开(公告)号：ZA200209484B
公开(公告)日：2004-02-23
申请号：ZA200209484
申请日：2002-11-21
Applicant: AVENTIS PHARMA INC
Inventor： ASTLES PETER C , HOUILLE OLIVIER , PAULS HEINZ , LIANG GUYAN , PRIBISH JAMES , EASTWOOD PAUL R , LEVELL JULIAN , CZEKAJ MARK , GONG YONG , NEUENSCHWANDER KENT
IPC: A61K31/451 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K45/00 , A61P1/02 , A61P1/16 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/06 , A61P19/06 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D211/26 , C07D211/32 , C07D211/58 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D411/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , C07D
Abstract: Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration of an inhibitor of tryptase, e.g., asthma and inflammatory diseases, to name only a few.
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公开(公告)号：BR0111206A
公开(公告)日：2003-04-15
申请号：BR0111206
申请日：2001-04-27
Applicant: AVENTIS PHARMA INC
Inventor： ASTLES PETER C , EASTWOOD PAUL R , HOUILLE OLIVIER , LEVELL JULIAN , PAULS HEINZ , CZEKAJ MARK
IPC: A61K31/451 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K45/00 , A61P1/02 , A61P1/16 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/06 , A61P19/06 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D211/26 , C07D211/32 , C07D211/58 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D411/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , C07D211/16
Abstract: Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration of an inhibitor of tryptase, e.g., asthma and inflammatory diseases, to name only a few.
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公开(公告)号：CA2409827A1
公开(公告)日：2001-11-29
申请号：CA2409827
申请日：2001-04-27
Applicant: AVENTIS PHARMA INC
Inventor： ASTLES PETER C , PAULS HEINZ , LEVELL JULIAN , HOUILLE OLIVIER , EASTWOOD PAUL R , NEUENSCHWANDER KENT , LIANG GUYAN , CZEKAJ MARK , PRIBISH JAMES , GONG YONG
IPC: A61K31/451 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K45/00 , A61P1/02 , A61P1/16 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/06 , A61P19/06 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D211/26 , C07D211/32 , C07D211/58 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D411/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , C07D211/16
Abstract: Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration of an inhibitor of tryptase, e.g., asthma and inflammatory diseases, to name only a few.
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