公开(公告)号：WO2004026820A3

公开(公告)日：2005-12-29

申请号：PCT/US0329702

申请日：2003-09-18

Applicant: AVENTIS PHARMA INC ,  LI ZHUYIN JULIE ,  MEHDI SHUJAATH

Inventor： LI ZHUYIN JULIE ,  MEHDI SHUJAATH

IPC: C07D20060101 ,  C07D201/00 ,  C12Q1/48 ,  C12Q1/68 ,  G01N21/64 ,  G01N33/483

CPC classification number: C12Q1/48

Abstract: Provided herein is a novel and useful method for determining whether a compound or agent decreases or inhibits the activity of a poly(ADP-ribose)-polymerase (PARP).

Abstract translation: 本文提供了一种用于确定化合物或试剂是否降低或抑制聚（ADP-核糖）聚合酶（PARP）的活性的新颖且有用的方法。

公开(公告)号：EP1581486A4

公开(公告)日：2007-05-02

申请号：EP03779081

申请日：2003-09-18

Applicant: AVENTIS PHARMA INC

Inventor： LI ZHUYIN JULIE ,  MEHDI SHUJAATH

IPC: C07D20060101 ,  C07D201/00 ,  C12Q1/48 ,  C12Q1/68 ,  G01N21/64 ,  G01N33/483

CPC classification number: C12Q1/48

Abstract: Provided herein is a novel and useful method for determining whether a compound or agent decreases or inhibits the activity of a poly(ADP-ribose)-polymerase (PARP).

公开(公告)号：DK1581486T3

公开(公告)日：2009-11-16

申请号：DK03779081

申请日：2003-09-18

Applicant: AVENTIS PHARMA INC

Inventor： LI ZHUYIN JULIE ,  MEHDI SHUJAATH

IPC: C12Q1/48 ,  C12Q1/68

Abstract: Provided herein is a novel and useful method for determining whether a compound or agent decreases or inhibits the activity of a poly(ADP-ribose)-polymerase (PARP).

公开(公告)号：AT437961T

公开(公告)日：2009-08-15

申请号：AT03779081

申请日：2003-09-18

Applicant: AVENTIS PHARMA INC

Inventor： LI ZHUYIN ,  MEHDI SHUJAATH

IPC: C12Q1/48 ,  C12Q1/68

Abstract: Provided herein is a novel and useful method for determining whether a compound or agent decreases or inhibits the activity of a poly(ADP-ribose)-polymerase (PARP).

公开(公告)号：AU2003285855A1

公开(公告)日：2004-04-08

申请号：AU2003285855

申请日：2003-09-18

Applicant: AVENTIS PHARMA INC

Inventor： LI ZHUYIN JULIE ,  MEHDI SHUJAATH

IPC: C07D20060101 ,  C07D201/00 ,  C12Q1/48 ,  C12Q1/68 ,  G01N21/64 ,  G01N33/483

公开(公告)号：DE60328628D1

公开(公告)日：2009-09-10

申请号：DE60328628

申请日：2003-09-18

Applicant: AVENTIS PHARMA INC

Inventor： LI ZHUYIN JULIE ,  MEHDI SHUJAATH

IPC: C12Q1/68

Abstract: Provided herein is a novel and useful method for determining whether a compound or agent decreases or inhibits the activity of a poly(ADP-ribose)-polymerase (PARP).

公开(公告)号：BRPI0509391A

公开(公告)日：2007-09-18

申请号：BRPI0509391

申请日：2005-03-29

Applicant: AVENTIS PHARMA INC

Inventor： WEINTRAUB PHILIP MARVIN ,  EASTWOOD PAUL R ,  MEHDI SHUJAATH ,  STEFANY DAVID W ,  MUSICK KWON YON ,  MOORCROFT NEIL ,  LIM SUNGTAEK ,  JIANG JOHN Z ,  RUTTEN HARTMUT ,  PEUKERT STEFAN ,  SCHWAHN UWE

IPC: C07D213/62 ,  A61K31/44 ,  A61P9/00 ,  C07D213/64 ,  C07D217/24 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/14

Abstract: The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

公开(公告)号：MXPA06011223A

公开(公告)日：2007-01-16

申请号：MXPA06011223

申请日：2005-03-29

Applicant: AVENTIS PHARMA INC

Inventor： WEINTRAUB PHILIP M ,  PEUKERT STEFAN ,  MEHDI SHUJAATH ,  MUSICK KWON YON ,  JIANG JOHN Z ,  MOORCROFT NEIL ,  EASTWOOD PAUL R ,  STEFANY DAVID W ,  LIM SUNGTAEK ,  RUTTEN HARTMUT ,  SCHWAHN UWE

IPC: A61K31/44 ,  A61P9/00 ,  A61P9/10 ,  A61P19/02 ,  A61P25/28 ,  A61P29/00 ,  C07D213/62 ,  C07D213/64 ,  C07D217/24 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/14

Abstract: La presente invencion se refiere a una serie de derivados de piridona 2,3,5-sustituidos de formula I: (Ver formula (I)) en la que R, R1, R2, R3 y R4 son como se definieron en la presente. Esta invencion tambien se refiere a metodos para fabricar estos compuestos. Los compuestos de esta invencion son inhibidores de la poli(adenosina 5'-difosfato ribosa)-polimerasa (PARP) y, por tanto, son utiles como agentes farmaceuticos, en especial en el tratamiento y/o prevencion de una diversidad de enfermedades, incluyendo enfermedades asociadas con el sistema nervioso central, y trastornos cardiovasculares.

公开(公告)号：AU2005230901A1

公开(公告)日：2005-10-20

申请号：AU2005230901

申请日：2005-03-29

Applicant: AVENTIS PHARMA INC

Inventor： RUTTEN HARTMUT ,  LIM SUNGTAEK ,  MOORCROFT NEIL ,  STEFANY DAVID W ,  SCHWAHN UWE ,  PEUKERT STEFAN ,  EASTWOOD PAUL R ,  MUSICK KWON YON ,  MEHDI SHUJAATH ,  JIANG JOHN Z ,  WEINTRAUB PHILIP M

IPC: A61K31/44 ,  C07D213/62 ,  C07D213/64 ,  C07D217/24 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/14

Abstract: The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

公开(公告)号：CA2537097A1

公开(公告)日：2005-03-17

申请号：CA2537097

申请日：2004-09-01

Applicant: AVENTIS PHARMA INC

Inventor： MUSICK KWON YON ,  JIANG JOHN Z ,  WEINTRAUB PHILIP M ,  EASTWOOD PAUL R ,  KOEHL JACK R ,  MEHDI SHUJAATH ,  MOORCROFT NEIL

IPC: A61K31/404 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/503 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61P9/10 ,  C07D209/40 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D471/04 ,  C07D487/08

Abstract: The present invention relates to a series of substituted indole derivatives of the formula I as described herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5~-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or preventi on of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.