公开(公告)号：EP2455376A1

公开(公告)日：2012-05-23

申请号：EP12155991.8

申请日：2010-06-10

Applicant: Abbott Laboratories

Inventor： Randolph, John T. ,  Matulenko, Mark A. ,  Keddy, Ryan G. ,  Jinkerson, Tammie K. ,  Hutchinson, Douglas K. ,  Flentge, Charles A. ,  Wagner, Rolf ,  Maring, Clarence J. ,  Tufano, Michael D. ,  Betebenner, David A. ,  Rockway, Todd W. ,  Degoey, David A. ,  Liu, Dachun ,  Pratt, John K. ,  Sarris, Kathy ,  Woller, Kevin R. ,  Wagaw, Seble H. ,  Califano, Jean C. ,  Li, Wenke ,  Caspi, Daniel D. ,  Bellizzi, Mary, E. ,  Gao, Yi ,  Kati, Warren M. ,  Hutchins, Charles W. ,  Donner, Pamela L. ,  Krueger, Allan C. ,  Motter, Christopher E ,  Nelson, Lissa T. ,  Patel, Sachin V.

IPC: C07D403/14 ,  C07D401/14 ,  C07D417/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/4439 ,  A61P31/14

CPC classification number: C07F9/65583 ,  C07C33/26 ,  C07C201/06 ,  C07C205/19 ,  C07D207/08 ,  C07D207/09 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D471/04 ,  C07D491/113 ,  C07K5/06

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Abstract translation: 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：EP2368890A1

公开(公告)日：2011-09-28

申请号：EP11160830.3

申请日：2010-06-10

Applicant: Abbott Laboratories

Inventor： Randolph, John T. ,  Degoey, David A. ,  Kati, Warren M. ,  Hutchins, Charles W. ,  Donner, Pamela L. ,  Krueger, Allan C. ,  Motter, Christopher E. ,  Nelson, Lissa T. ,  Patel, Sachin V. ,  Matulenko, Mark A. ,  Keddy, Ryan G. ,  Jinkerson, Tammie K. ,  Soltwedel, Todd N. ,  Hutchinson, Douglas K. ,  Flentge, Charles A. ,  Wagner, Charles A. ,  Maring, Clarence J. ,  Tufano, Michael D. ,  Betebenner, David A. ,  Rockway, Todd W. ,  Liu, Dachun ,  Pratt, John K. ,  Lavin, Michael J. ,  Sarris, Kathy ,  Woller, Kevin R. ,  Wagaw, Seble H. ,  Califano, Jean C. ,  Li, Wenke ,  Caspi, Daniel D. ,  Bellizzi, Mary E.

IPC: C07D403/14 ,  C07D401/14 ,  C07D417/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/4439 ,  A61P31/14

CPC classification number: C07F9/65583 ,  C07C33/26 ,  C07C201/06 ,  C07C205/19 ,  C07D207/08 ,  C07D207/09 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D471/04 ,  C07D491/113 ,  C07K5/06

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Abstract translation: 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：EP1315698A1

公开(公告)日：2003-06-04

申请号：EP99917414.7

申请日：1999-04-12

Applicant: ABBOTT LABORATORIES

Inventor： Maring, Clarence J. ,  Gu, Yu-Gui ,  Chen, Hui-Ju ,  Chen, Yuanwei ,  Degoey, David A. ,  Flosi, William J. ,  Giranda, Vincent L. ,  Grampovnik, David J. ,  Kati, Warren M. ,  Kempf, Dale J. ,  Klein, Larry L. ,  Krueger, Allan C. ,  Lin, Zhen ,  Madigan, Darold L. ,  McDaniel, Keith F. ,  Muchmore, Steven W. ,  Sham, Hing L. ,  Stewart, Kent D. ,  Stoll, Vincent S. ,  Sun, Minghua ,  Wang, Gary T. ,  Wang, Sheldon ,  Xu, Yibo ,  Yeung, Ming C. ,  Zhao, Chen ,  Kennedy, April

IPC: C07D207/16

CPC classification number: C07D207/327 ,  C07D207/16 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/06 ,  C07D409/06 ,  C07D413/04 ,  C07D417/04 ,  C07D417/06 ,  C07F9/5722

Abstract: Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.