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    METHOD AND SYSTEM FOR SPECTRAL IMAGING
    1.
    发明申请
    METHOD AND SYSTEM FOR SPECTRAL IMAGING 审中-公开

    公开(公告)号：WO2014064701A9

    公开(公告)日：2014-05-01

    申请号：PCT/IL2013/050868

    申请日：2013-10-24

    Applicant: APPLIED SPECTRAL IMAGING LTD.

    Inventor： KATZIR, Nir

    IPC: G01B9/02 ,  G02B27/10 ,  G01B11/02 ,  A61B6/00

    Abstract: A method of calibrating a spectral imaging system is disclosed. The spectral imaging system comprises an interferometer having a beam splitter and at least a first reflector and a second reflector. The method comprises: obtaining data pertaining to an interference pattern model, operating the spectral imaging system to provide an interference pattern of a received light beam, and varying a relative orientation between at least two of: the beam splitter, the first reflector and the second reflector, until the interference pattern of the input light beam substantially matches the interference pattern model.

    METHODS AND SYSTEMS FOR ANALYZING BIOLOGICAL SAMPLES
    2.
    发明申请
    METHODS AND SYSTEMS FOR ANALYZING BIOLOGICAL SAMPLES 审中-公开
    分析生物样品的方法和系统

    公开(公告)号：WO2007080583A2

    公开(公告)日：2007-07-19

    申请号：PCT/IL2007/000034

    申请日：2007-01-09

    Applicant: APPLIED SPECTRAL IMAGING LTD. ,  KATZIR, Nir ,  KOLATT, Tsafrir ,  BAR-AM, Irit

    Inventor： KATZIR, Nir ,  KOLATT, Tsafrir ,  BAR-AM, Irit

    IPC: C12Q1/68 ,  G06F19/00

    CPC classification number: C12Q1/6841 ,  G06K9/00134

    Abstract: Methods, computer readable storage media and systems which can be used for analyzing labeled biological samples, identifying chromosomal aberrations, identifying genetically abnormal cells and/or computationally scanning the samples using randomly or randomized scanning methods are provided. Specifically, the present invention can be used to analyze FISH-stained samples and automatically identify chromosomal aberrations associated with abnormal intensity ratio of stained occurrences in the sample.

    Abstract translation: 提供了可用于分析标记的生物样品，识别染色体畸变，识别遗传异常细胞和/或使用随机或随机扫描方法计算扫描样品的方法，计算机可读存储介质和系统。 具体地，本发明可用于分析FISH染色的样品，并自动识别与样品中染色事件的异常强度比相关的染色体畸变。

    METHOD AND SYSTEM FOR SPECTRAL IMAGING
    4.
    发明公开
    METHOD AND SYSTEM FOR SPECTRAL IMAGING 审中-公开
    VERFAHREN UND系统ZUR SPEKTRALEN ABBILDUNG

    公开(公告)号：EP2986928A1

    公开(公告)日：2016-02-24

    申请号：EP13848356.5

    申请日：2013-10-24

    Applicant: Applied Spectral Imaging Ltd.

    Inventor： KATZIR, Nir

    IPC: G01B9/02 ,  G02B27/10 ,  G01B11/02 ,  A61B6/00

    CPC classification number: G01J3/4532 ,  G01J3/0237 ,  G01J3/0297 ,  G01J3/2823 ,  G01J3/45 ,  G02B27/144

    Abstract: A method of calibrating a spectral imaging system is disclosed. The spectral imaging system comprises an interferometer having a beam splitter and at least a first reflector and a second reflector. The method comprises: obtaining data pertaining to an interference pattern model, operating the spectral imaging system to provide an interference pattern of a received light beam, and varying a relative orientation between at least two of: the beam splitter, the first reflector and the second reflector, until the interference pattern of the input light beam substantially matches the interference pattern model.

    Abstract translation: 公开了一种校准光谱成像系统的方法。 光谱成像系统包括具有分束器和至少第一反射器和第二反射器的干涉仪。 该方法包括：获得关于干涉图案模型的数据，操作光谱成像系统以提供接收光束的干涉图案，以及改变以下中的至少两个之间的相对取向：分束器，第一反射器和第二反射器 反射器，直到输入光束的干涉图案基本上与干涉图案模型相匹配。

    METHOD FOR CHROMOSOMES CLASSIFICATION
    5.
    发明公开
    METHOD FOR CHROMOSOMES CLASSIFICATION 失效
    分类程序染色体

    公开(公告)号：EP0920537A1

    公开(公告)日：1999-06-09

    申请号：EP98913120.0

    申请日：1998-03-27

    Applicant: Applied Spectral Imaging Ltd.

    Inventor： GARINI, Yuval ,  KATZIR, Nir ,  WINE, David ,  CABIB, Dario

    IPC: G01N33 ,  C12M1 ,  C12M3 ,  C12N15 ,  C12Q1 ,  G01J3 ,  G01N1 ,  G01N21 ,  G01N37 ,  G02B21 ,  G06K9

    CPC classification number: G01J3/12 ,  C12Q1/6816 ,  G01J3/02 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/4406 ,  G01J3/453 ,  G01J2003/2866 ,  G01N21/6428 ,  G01N21/6456 ,  G01N33/5005 ,  G01N33/56966 ,  G01N33/582 ,  G01N2021/6423 ,  G01N2021/6441 ,  G06K9/00127 ,  G06K9/0014 ,  G06K9/76

    Abstract: A method for finding L internal reference vectors for classification of L chromosomes or portions of chromosomes of a cell, the L chromosomes or portions of chromosomes being painted with K different fluorophores or combinations thereof, wherein K basic chromosomes or portions of chromosomes of the L chromosomes or portions of chromosomes are each painted with only one of the K different fluorophores, whereas the other L-K of the L chromosomes or portions of chromosomes are each painted with a different combination of the K different fluorophores, the method comprising the steps of (a) using a multi-band collection device for measuring a first vector for each pixel of each of the L chromosomes or portions of chromosomes; (b) identifying pixels belonging to each of the K basic chromosomes or portions of chromosomes and defining the pixels as basic pixels, so as to obtain K basic classes of basic pixels; (c) using at least one basic pixel from each of the K basic classes for obtaining K basic vectors, the K basic vectors being K internal reference vectors; (d) using the K basic vectors for identifying pixels belonging to the other L-K chromosomes or portions of chromosomes; and (e) using the pixels belonging to the other L-K chromosomes or portions of chromosomes for calculating the other L-K internal reference vectors, thereby finding all of the L internal reference vectors. A method for classification of L chromosomes or portions of chromosomes of a cell similarly painted using the above method for finding L internal reference vectors, and using the L reference vectors for classification of each of the pixels into one of L classification classes. And, images presenting color chromosomes.

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