公开(公告)号：HK1045846A1

公开(公告)日：2002-12-13

申请号：HK02107037

申请日：2002-09-26

Applicant: BASF AG

Inventor： HEINZ HILLEN ,  MARTIN SCHMIDT ,  HELMUT MACK ,  WERNER SEITZ ,  ANDREAS HAUPT ,  JOHANN-CHRISTIAN ZECHEL ,  ANDREAS KLING

IPC: C07K20060101 ,  C12N9/99 ,  A61K20060101 ,  A61K38/00 ,  A61K38/55 ,  A61P20060101 ,  A61P1/04 ,  A61P1/18 ,  A61P5/14 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/02 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P37/02 ,  C07B43/00 ,  C07D20060101 ,  C07D401/12 ,  C07D409/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/068 ,  C07K5/072 ,  C07K5/078

公开(公告)号：HK1041007A1

公开(公告)日：2002-06-28

申请号：HK02101870

申请日：2002-03-12

Applicant: BASF AG

Inventor： KURT RITTER ,  BERND JANSSEN ,  ANDREAS HAUPT ,  ANDREAS KLING ,  TERESA BARLOZZARI ,  WILHELM AMBERG

IPC: A61K38/00 ,  C07K20060101 ,  A61K20060101 ,  A61K35/56 ,  A61P35/00 ,  C07K5/103 ,  C07K5/117 ,  C07K7/02

公开(公告)号：ID24669A

公开(公告)日：2000-07-27

申请号：ID20000322

申请日：1998-07-07

Applicant: BASF AG

Inventor： BERND JANSSEN ,  TERESA BARLOZZARI ,  ANDREAS HAUPT ,  THOMAS ZIERKE ,  ANDREAS KLING

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34

Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.