公开(公告)号：RU2153504C2

公开(公告)日：2000-07-27

申请号：RU96123123

申请日：1995-04-26

Applicant: BASF AG

Inventor： VIL GEL M AMBERG ,  KHARAL D BERNARD ,  EHRNST BUSHMANN ,  ANDREAS KHAUPT ,  LOTAR JANICHKE ,  BERND JANSSEN ,  UL RIKH KARL ,  ANDREAS KLING ,  SHTEFAN MJULLER ,  BERND DEH POTTSOLLI ,  KURT RITTER ,  MARKO TIES ,  TOMAS TSIRKE

IPC: A61K38/08 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  A61K38/00 ,  C07K7/06 ,  C07K14/52

Abstract: medicine. SUBSTANCE: described is pentapeptide hydrochloride of formula I: Me2Val-Val-MeVai-Pro-Pro-NHBzl.HCl (I) wherein Me is methyl and Bzl is benzyl. Compound has antitumor activity. Also described are methods of preparation thereof. EFFECT: improved properties of the title compound. 6 cl, 2 ex

公开(公告)号：RU95115135A

公开(公告)日：1997-06-10

申请号：RU95115135

申请日：1993-12-04

Applicant: BASF AG

Inventor： ANDREAS KHAUPT ,  BERND JANSSEN ,  KURT RITTER ,  DAGMAR KLINGE ,  GERKHARD KEJL KHAUER ,  SINTIJA ROMERDAL ,  TEREZA BARLOZZARI ,  KSIAO-DONG KVIAN

IPC: A61K38/00 ,  C07K5/103 ,  A61K38/07 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06

Abstract: Описаныновыепептидыформулы I,вкоторойзначения R, R, X, А, R, В, D, E, R, M, Q, a, b и d указаныв описании, испособыихполучения. Новыевеществаобладаютантинеопластическимдействием.

公开(公告)号：HK1053831A1

公开(公告)日：2003-11-07

申请号：HK03104425

申请日：2003-06-19

Applicant: BASF AG

Inventor： GAVIN C HIRST ,  KURT RITTER ,  PAUL RAFFERTY ,  STEPHEN ST GALLAY ,  DAVID CALDERWOOD ,  HELEN L TWIGGER

IPC: C07D20060101 ,  A61K20060101 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/55 ,  A61K38/00 ,  A61P20060101 ,  A61P1/18 ,  A61P3/10 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  A61P15/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P33/02 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  C07D471/04 ,  C07D487/04 ,  C07F9/6561

公开(公告)号：HK1041007A1

公开(公告)日：2002-06-28

申请号：HK02101870

申请日：2002-03-12

Applicant: BASF AG

Inventor： KURT RITTER ,  BERND JANSSEN ,  ANDREAS HAUPT ,  ANDREAS KLING ,  TERESA BARLOZZARI ,  WILHELM AMBERG

IPC: A61K38/00 ,  C07K20060101 ,  A61K20060101 ,  A61K35/56 ,  A61P35/00 ,  C07K5/103 ,  C07K5/117 ,  C07K7/02

公开(公告)号：RU2132334C1

公开(公告)日：1999-06-27

申请号：RU95115135

申请日：1993-12-04

Applicant: BASF AG

Inventor： ANDREAS KHAUPT ,  BERND JANSSEN ,  KURT RITTER ,  DAGMAR KLINGE ,  GERKHARD KEJL KHAUER ,  SINTIJA ROMERDAL ,  TEREZA BARLOZZARI ,  KSIAO-DONG KVIAN

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06

Abstract: FIELD: organic chemistry, peptides. SUBSTANCE: invention relates to peptides of the general formula (I) where R is C 1-7 -alkyl; R is C 1-4 -alkyl; X is C 1-5 -alkyl; R is a lower alkyl; B - is C 1-5 -alkyl; D is C 1-5 -alkoxy; M - phenylalanine; R - H; R - H or benzyl; d = 0 or 1, or their salts showing the improved therapeutic properties for treatment of patients with neoplasms as compared with dolostatine-10. Proposed analog can be synthesized by conventional methods unlike to the latter. EFFECT: improved therapeutic properties. 2 cl, 2 tbl, 2 ex