公开(公告)号：JPH11322586A

公开(公告)日：1999-11-24

申请号：JP9491299

申请日：1999-04-01

Applicant: BASF AG

Inventor： MEFFERT HELMUT DR ,  RUCHATZ FOLKER DR

IPC: A61K9/16 ,  A61K8/72 ,  A61K8/81 ,  A61K9/20 ,  A61K9/26 ,  A61K47/30 ,  C08F226/00 ,  C08F226/06 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To produce a solid medicine and a cosmetic which release active ingredients under controlling by using a copolymer consisting of N-vinyllactam or N-vinylamine and a specific monomer as a matrix. SOLUTION: This solid medicine and cosmetic are produced by using a copolymer which consists of (A) 50-99 wt.% of at least one kind of N-vinyllactam or N-vinylamine selected from N-vinylpyrrolidone, N-vinylpiperidone, N- vinylcaprolactam, (methylated) N-vinylimidazole or N-vinylformamide and (B) 1-50 wt.% of a monomer selected from (i) a 14-30C alkyl monoethylenically unsaturated 3-8C carboxylate, (ii) the same carboxylic acid N-8-30C alkyl substituted amide, (iii) the same carboxylic acid N,N-8-30C dialkyl substituted amide, (iv) a vinyl aliphatic 8-30C carboxylate or (v) an 8-30C alkyl vinyl ether as a matrix.

公开(公告)号：JP2000063244A

公开(公告)日：2000-02-29

申请号：JP22993799

申请日：1999-08-16

Applicant: BASF AG

Inventor： MEFFERT HELMUT DR ,  TIEFENSEE KRISTIN

IPC: A61K8/00 ,  A61K8/02 ,  A61K8/60 ,  A61K8/72 ,  A61K8/81 ,  A61Q5/00 ,  A61Q5/02 ,  C11D1/66 ,  C11D3/37 ,  C11D17/00 ,  A61K7/075 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain a thickening agent for use in surfactant-contg. formulations, in particular useful in hair cleansing agents. SOLUTION: This thickening agent is a neutralized or partially neutralized copolymer obtained from (A) 50-99 wt.% of a monoethylene-based unsaturated carboxylic acid and (B) 1-50 wt.% of at least one comonomer selected from the group consisting of (a) esters of monoethylene-based unsaturated carboxylic acids and saturated 8-30C alcohols, (b) N-alkyl- or N,N-dialkyl-substituted carboxyamides, wherein the alkyl groups are mutually independently >=8-18C aliphatic or alicyclic alkyl groups, (c) aliphatic 8-30C carboxylic acid vinyl esters, and (d) 8-18C alkyl vinyl ethers, or a mixture of monomers each selected from the groups (a) to (d).

公开(公告)号：JP2000001595A

公开(公告)日：2000-01-07

申请号：JP9811399

申请日：1999-04-05

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN DR ,  NEGELE ANTON ,  MEFFERT HELMUT DR ,  SANNER AXEL DR

IPC: A61K47/32 ,  A01N25/10 ,  A61K8/72 ,  A61K8/81 ,  B01F17/00 ,  B01F17/52 ,  C08L39/00 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain a compsn. which makes the better dissolution of a water- insoluble component possible by incorporating the water-insoluble component and a copolymer formed from an N-vinylcarboxamide and a hydrophobic monomer copolymerizable therewith into the same. SOLUTION: At least one water-insoluble component which is pref. an acting substance or an auxiliary agent used for medicines or cosmetics, for plant treatments, or for nutrition industries and at least one copolymer formed from 5-99 wt.% at least one N-vinylcarboxamide represented by the formula, 1-95 wt.% at least one hydrophobic monomer copolymerizable therewith, and optionally 0-94 wt.% another copolymerizable monomer are incorporated. In the formula, R1 and R2 are each H or 1-6C alkyl. Pref. examples of the hydrophobic monomer are esters of monoethylenic unsatd. 3-8C carboxylic acids and aliph. or alicyclic 8-30C alcohols (e.g. stearyl acrylate).

公开(公告)号：JP2000063288A

公开(公告)日：2000-02-29

申请号：JP22934999

申请日：1999-08-13

Applicant: BASF AG

Inventor： MEFFERT HELMUT DR ,  RUCHATZ FOLKER DR

IPC: A61K47/32 ,  A61K8/30 ,  A61K9/20 ,  A61K9/22 ,  A61K9/32 ,  A61K31/138 ,  A61K31/655 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain the subject medicine and cosmetic having a sustained releasability by using a cololymer comprising N-vinylpyrrolidone and vinyl acetate in a specific ratio and having a specific range of K-value. SOLUTION: A copolymer comprising (A) 15-50 wt.%, preferably 20-40 wt.%, particularly preferably 25-35 wt.% N-vinylpyrrolidone, (B) 85-50 wt.%, preferably 80-60 wt.%, particularly preferably 75-65 wt.% vinyl acetate and preferably (C) 0-30 wt.% other radical-copolymerizable monomers (e.g. monoethylene-based unsaturated carboxylic acids such as acrylic acid, methacrylic acid, etc.), and having 50-200 K-value is used as a matrix for production of a solid oral medicine and cosmetic.

公开(公告)号：JPH11310618A

公开(公告)日：1999-11-09

申请号：JP7240899

申请日：1999-03-17

Applicant: BASF AG

Inventor： MEFFERT HELMUT DR ,  SANNER AXEL DR ,  BERNDL GUNTHER ,  RUCHATZ FOLKER DR ,  KOLTER KARL DR ,  BAUER KURT HEINZ

IPC: A61K8/63 ,  A61K9/00 ,  A61K9/107 ,  A61K9/20 ,  A61K9/48 ,  A61K47/32 ,  C08F220/04 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain a solubilizing agent having a sufficient solubility and high solubilizing activities in water, and capable of being applied to medicines, cosmetics and foods. SOLUTION: This use is the one of copolymers comprising (a) 82-99.9 mol.% of at least one monoethylenically unsaturated a 3-8C carboxylic acid, (b) 0.1-18 mol.% of at least one monomer selected from the group of (b1 ) N-(8-30C alkyl)- substituted amides of monoethylenically unsaturated 3-8C carboxylic acids, (b2 ) N,N-(8-30C dialkyl)-substituted amides of monoethylenically unsaturated 3-8C carboxylic acids and (b3 ) 8-30C alkyl esters of monoethylenically unsaturated 3-8C carboxylic acids, and (c) 0-17.9 mol.% of at least one monomer selected from the group of (c1 ) vinyl esters of aliphatic 8-30C carboxylic acids and (c2 ) 8-30C alkylvinyl ethers, in which the mol.% data for the individual components adding up to 100%, as a solubilizer.

公开(公告)号：JP2000248004A

公开(公告)日：2000-09-12

申请号：JP2000047856

申请日：2000-02-24

Applicant: BASF AG

Inventor： MEFFERT HELMUT DR ,  ANGEL MAXIMILIAN DR

IPC: A61K9/10 ,  A61K47/32 ,  C08F2/10 ,  C08F2/16 ,  C08F2/22 ,  C08F220/10 ,  C08F220/68 ,  C08F226/00 ,  C08F226/02 ,  C08F226/06 ,  C09D139/00

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing an aqueous dispersion of a high- molecular weight copolymer formed from a hydrophilic and a hydrophobic monomer of which the each exhibits different reaction behaviors in different pH ranges. SOLUTION: This method for producing an aqueous dispersion of a copolymer comprises by subjecting ethylenic unsaturated monomers to free radical polymerization under controlling pH conditions in an aqueous medium, wherein the ethylenic unsaturated monomers comprise (a) 10-90 wt.% of at least one hydrophilic monomer A having an N-vinyl group and giving the maximum polymerization rate at a pH value of >7 and (b) 10-90 wt.% of at least one monoethylenic unsaturated hydrophobic monomer B giving the maximum polymerization rate at a pH value of

公开(公告)号：JPH11343250A

公开(公告)日：1999-12-14

申请号：JP9495199

申请日：1999-04-01

Applicant: BASF AG

Inventor： HUFF JUERGEN DR ,  MEFFERT HELMUT DR ,  RUCHATZ FOLKER DR

IPC: A23L1/00 ,  A01N25/02 ,  A23L3/3481 ,  A61K8/00 ,  A61K8/72 ,  A61K8/81 ,  A61K8/86 ,  A61K8/91 ,  A61K9/00 ,  A61K9/08 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K31/44 ,  A61K47/10 ,  A61K47/30 ,  A61K47/32 ,  A61K47/34 ,  A61Q13/00 ,  A61Q17/04 ,  A61Q19/00 ,  B01F17/00 ,  B01F17/52 ,  C08F285/00 ,  C08F291/06 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a solubilizing agent capable of solubilizing hydrophobic substances and useful in e.g. producing homogeneous pharmaceutical preparations by using a copolymer formed by grafting specific monomer(s) to a polyalkylene oxide. SOLUTION: This solubilizing agent is obtained by using a graft copolymer formed by grafting to (A) a polyalkylene oxide (pref. with a number-average molecular weight of 300-100,000) (B) at least one monomer selected from the group consisting of (i) monoethylenically unsaturated 3-8C carboxylic acid 1-30C alkyl esters, (ii) aliphatic 1-30C carboxylic acid vinyl esters, (iii) 1-30C alkyl vinyl ethers, (iv) monoethylenically unsaturated 3-8C carboxylic acid N-1-30C alkyl-substituted amides, and (v) monoethylenically unsaturated 3-8C carboxylic acid N,N-1-30C dialkyl-substituted amides.

公开(公告)号：JPH10314571A

公开(公告)日：1998-12-02

申请号：JP12341798

申请日：1998-05-06

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN DR ,  MEFFERT HELMUT DR ,  BERNDL GUNTHER DR ,  SANNER AXEL DR ,  STEIN STEFAN DR ,  SCHEHLMANN VOLKER DR ,  RUCHATZ FOLKER DR

IPC: A61K8/72 ,  A61K8/00 ,  A61K8/81 ,  A61K47/14 ,  A61K47/30 ,  A61K47/32 ,  A61Q19/00 ,  B01F17/32 ,  B01F17/52 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To prepare a solubilization agent for an insoluble action substance. SOLUTION: A copolymer composed of monomers selected out of following items or a mixture of the monomers of 1-40 molar% is used in a prepared material of a water-insoluble substance, and the items are: A) N-vinylpyrrolidone of 60-99% and B) Following groups: b1) monoethylene unsaturated C3 -C8 - carboxylic acid of C8 -C30 -alkylester b2) acrylic acid or methacrylic acid N,N- dialkyl-allyl having C8 -C18 alkyl- or N,N-dialkyl-substituted amide, or b3) aliphatic C8 -C30 -carboxylic acid vinylester.

公开(公告)号：DE59913213D1

公开(公告)日：2006-05-11

申请号：DE59913213

申请日：1999-03-11

Applicant: BASF AG

Inventor： MEFFERT HELMUT DR ,  SANNER AXEL DR ,  BERNDL GUNTHER DR ,  RUCHATZ FOLKER DR ,  KOLTER KARL DR ,  BAUER KURT HEINZ PROF DR

IPC: A61K8/81 ,  A61K8/63 ,  A61K9/00 ,  A61K9/107 ,  A61K9/20 ,  A61K9/48 ,  A61K47/32 ,  C08F220/04 ,  C08F222/04

Abstract: The invention relates to the use of copolymers comprising a) 82 to 99.9 mol % of at least one monoethylenically unsaturated C3-C8-carboxylic acid; b) 0.1 to 18 mol % of at least one monomer selected from the group b1) N-C8-C30-alkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids, b2) N,N-C8-C30-dialkyl-substituted amides of mono-ethylenically unsaturated C3-C8-carboxylic acids, b3) C8-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids; c) 0 to 17.9 mol % of at least one monomer selected from the group of c1) vinyl esters of aliphatic C8-C30-carboxylic acids, c2) C8-C30-alkylvinyl ethers, the mol % data for the individual components adding up to 100%, as solubilizer.

公开(公告)号：DE59914645D1

公开(公告)日：2008-03-27

申请号：DE59914645

申请日：1999-03-25

Applicant: BASF AG

Inventor： HUFF JUERGEN DR ,  MEFFERT HELMUT DR ,  RUCHATZ FOLKER DR

IPC: A23L1/00 ,  A61K9/16 ,  A01N25/02 ,  A23L3/3481 ,  A61K8/00 ,  A61K8/72 ,  A61K8/81 ,  A61K8/86 ,  A61K8/91 ,  A61K9/00 ,  A61K9/08 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/44 ,  A61K47/10 ,  A61K47/30 ,  A61K47/32 ,  A61K47/34 ,  A61Q13/00 ,  A61Q17/04 ,  A61Q19/00 ,  C08F285/00 ,  C08F291/06 ,  C09K23/00 ,  C09K23/52

Abstract: The use of graft copolymers obtainable by graftinga) polyalkylene oxides withb) at least one monomer selected from the group ofb1) C1-C30-alkyl esters of monoethylenically unsaturated C3-C8-carboxylic acids;b2) vinyl esters of aliphatic C1-C30-carboxylic acids;b3) C1-C30-alkyl vinyl ethers;b4) N-C1-C12-alkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids;b5) N,N-C1-C12-dialkyl-substituted amides of monoethylenically unsaturated C3-C8-carboxylic acids as solubilizer.