公开(公告)号：DE4341402A1

公开(公告)日：1995-06-08

申请号：DE4341402

申请日：1993-12-04

Applicant: BASF AG

Inventor： STEINER GERD DR ,  MUNSCHAUER RAINER DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  HOEGER THOMAS DR

IPC: C07D401/04 ,  A61K31/40 ,  A61K31/403 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/505 ,  A61P25/00 ,  A61P25/02 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07D209/02 ,  C07D209/46 ,  C07D209/52 ,  C07D209/90 ,  C07D209/96 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D413/06 ,  C07D417/04 ,  C07D417/14 ,  C07B37/10

Abstract: PCT No. PCT/EP94/03910 Sec. 371 Date Apr. 19, 1996 Sec. 102(e) Date Apr. 19, 1996 PCT Filed Nov. 26, 1994 PCT Pub. No. WO95/15312 PCT Pub. Date Jun. 8, 1995Compounds of the formula I I where the substituents have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.

公开(公告)号：DE4427648A1

公开(公告)日：1996-02-08

申请号：DE4427648

申请日：1994-08-04

Applicant: BASF AG

Inventor： STEINER GERD DR ,  MUNSCHAUER RAINER DR ,  HOEGER THOMAS DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME

IPC: C07D401/06 ,  A61K31/40 ,  A61K31/415 ,  A61K31/47 ,  A61K31/505 ,  A61P25/18 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D513/04 ,  C07D513/02

Abstract: Compounds are disclosed having the formula (I), in which R , R , A, X, Y and Z have the meanings given in the description, as well as their preparation. These new compounds are useful for fighting diseases.

公开(公告)号：DE4403666A1

公开(公告)日：1995-08-10

申请号：DE4403666

申请日：1994-02-07

Applicant: BASF AG

Inventor： HOEGER THOMAS DR ,  ULTSCH ANDREAS DR ,  BACH ALFRED DR ,  STERRER SYLVIA DR ,  LEMAIRE HANS-GEORG DR

IPC: G01N33/567 ,  C07K14/705 ,  C12N15/09 ,  C12N15/12 ,  C12Q1/68 ,  C12Q1/00 ,  C07H21/04

Abstract: The invention pertains to new glutamate receptor subunits and DNA sequences coding for them and to methods for producing DNA sequences and receptors. The invention also pertains to methods for identifying functional ligands for these receptors.

公开(公告)号：DE4341400A1

公开(公告)日：1995-06-08

申请号：DE4341400

申请日：1993-12-04

Applicant: BASF AG

Inventor： STEINER GERD DR ,  MUNSCHAUER RAINER DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  HOEGER THOMAS DR

IPC: C07D209/72 ,  A61K31/40 ,  C07D417/06 ,  C07D471/18 ,  C07D487/18 ,  C07D491/18

Abstract: 4,7-Bridged tetra- or hexa hydro-isoindoline derivs. of formula (I) and their acid-addn. salts are new. B = CH2, C2H4, NH, NMe or NCOMe; R1 = H or phenyl, opt. mono- or disubstd. by halo, 1-4C alkyl, CF3, OH, 1-4C alkoxy, NH2, NHMe, NMe2, CN or NO2; n = 0-4; A = H, CR2R4, N(R5)COR4, N(R5)SO2R4, OSO2R4, CH = CHR4, or CH=C(R4)2; R2 = H, OH, or phenyl opt. substd. by F, Cl or Br; R3 = H; or R2 + R3 = O; R4 = phenyl, or thienyl opt. mono- or disubstd. by F, Cl, Br, OH, NO2, NH2, 1-4C alkanoylamino, 1-4C alkylamino, 1-4C alkyl or OMe; R5 = H or Me.

公开(公告)号：DE4338397A1

公开(公告)日：1995-05-11

申请号：DE4338397

申请日：1993-11-10

Applicant: BASF AG

Inventor： STEINER GERD DR ,  MUNSCHAUER RAINER DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  HOEGER THOMAS DR

IPC: C07D403/06 ,  C07D491/18 ,  A61K31/505 ,  A61K31/53 ,  A61K31/54 ,  C07D471/04 ,  C07D513/04 ,  C07D519/00

Abstract: Compounds of the formula I wherein B, R , R , n, A, X, Y, Z and the 5,6 bond have the meaning indicated in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.

公开(公告)号：CZ287862B6

公开(公告)日：2001-02-14

申请号：CZ31097

申请日：1995-07-21

Applicant: BASF AG

Inventor： STEINER GERD DR ,  MUNSCHAUER RAINER DR ,  HOEGER THOMAS DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS JUERGEN DR

IPC: C07D401/06 ,  A61K31/40 ,  A61K31/415 ,  A61K31/47 ,  A61K31/505 ,  A61P25/18 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D513/04 ,  A61K31/403

Abstract: In the present invention there are disclosed the compounds of the general formula I, in which Re1, Re2, A, X, Y and Z have specific meaning and process of their preparation. The invented novel compounds are suitable for treating diseases of nervous system.

公开(公告)号：DE4427647A1

公开(公告)日：1996-02-08

申请号：DE4427647

申请日：1994-08-04

Applicant: BASF AG

Inventor： STEINER GERD DR ,  MUNSCHAUER RAINER DR ,  HOEGER THOMAS DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME

IPC: C07D409/12 ,  A61K31/40 ,  A61K31/403 ,  A61P25/18 ,  A61P43/00 ,  C07D209/44 ,  C07D209/52 ,  C07D209/90 ,  C07D209/92 ,  C07D403/06 ,  C07D209/80 ,  C07D209/34 ,  A61K31/645

Abstract: New compounds having the formula (I), in which A, R and n have the meanings given in the description, are useful for fighting diseases.

公开(公告)号：DE4410882A1

公开(公告)日：1995-10-05

申请号：DE4410882

申请日：1994-03-29

Applicant: BASF AG

Inventor： STERRER SYLVIA DR ,  ULTSCH ANDREAS DR ,  HOEGER THOMAS DR ,  LEMAIRE HANS-GEORG DR ,  BACH ALFRED DR

IPC: G01N33/566 ,  C07K14/705 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12R1/91 ,  C12N15/79 ,  C12Q1/00 ,  G01N33/50

Abstract: The invention concerns a method for the preparation of eucaryotic cell lines for the permanently ectopic expression of glutamate receptors, the cell lines being prepared by the transformation of cells containing nucleic acids coding for glutamate receptors. The method is characterized in that, during the establishment of the cell lines, at least one of the following conditions is satisfied for the culture: a) the transformed cells are cultured in a culture medium containing a glutamate precursor; b) the transformed cells are cultured in the presence of a glutamate-receptor antagonist; c) the transformed cells are cultured in a first phase under conditions in which glutamate-receptor expression is repressed and in a second phase under conditions in which the repression is discontinued. The invention also concerns the cell lines thus obtained and their use.

公开(公告)号：DE4341403A1

公开(公告)日：1995-06-08

申请号：DE4341403

申请日：1993-12-04

Applicant: BASF AG

Inventor： STEINER GERD DR ,  MUNSCHAUER RAINER DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  HOEGER THOMAS DR

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P21/02 ,  A61P25/08 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D209/14 ,  C07D209/18 ,  C07D209/44 ,  C07D209/52 ,  C07D487/04 ,  C07D491/048 ,  C07D497/04 ,  C07D487/08 ,  C07D417/12 ,  C07D498/18 ,  C07D471/18 ,  A61K31/46

Abstract: PCT No. PCT/EP94/03913 Sec. 371 Date Jun. 6, 1996 Sec. 102(e) Date Jun. 6, 1996 PCT Filed Nov. 26, 1994 PCT Pub. No. WO95/15327 PCT Pub. Date Jun. 8, 1995Compounds of the formula I I where B, R1, R2, n and A have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.