公开(公告)号：DE3931841A1

公开(公告)日：1991-04-04

申请号：DE3931841

申请日：1989-09-23

Applicant: BASF AG

Inventor： BACH ALFRED DR ,  SEEBURG PETER H PROF DR

IPC: C07K14/705 ,  C07K14/725 ,  C12N1/15 ,  C12N1/21 ,  C12N15/12

Abstract: New polypeptides are described which are dopamine D2 receptors. The polypeptides are produced by genetic engineering.

公开(公告)号：DE4403666A1

公开(公告)日：1995-08-10

申请号：DE4403666

申请日：1994-02-07

Applicant: BASF AG

Inventor： HOEGER THOMAS DR ,  ULTSCH ANDREAS DR ,  BACH ALFRED DR ,  STERRER SYLVIA DR ,  LEMAIRE HANS-GEORG DR

IPC: G01N33/567 ,  C07K14/705 ,  C12N15/09 ,  C12N15/12 ,  C12Q1/68 ,  C12Q1/00 ,  C07H21/04

Abstract: The invention pertains to new glutamate receptor subunits and DNA sequences coding for them and to methods for producing DNA sequences and receptors. The invention also pertains to methods for identifying functional ligands for these receptors.

公开(公告)号：DE4023699A1

公开(公告)日：1992-01-30

申请号：DE4023699

申请日：1990-07-26

Applicant: BASF AG

Inventor： BACH ALFRED DR ,  HILLEN HEINZ DR ,  BIALOJAN SIEGFRIED DR

IPC: A61K38/00 ,  A61K35/76 ,  A61K38/46 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/31 ,  C12N15/57

Abstract: Described are glycosylated, partially glycosylated or unglycosylated polypeptides with the amino-acid sequence given in the sequence protocol and in which up to 10 amino acid groups can be replaced by other, naturally occurring, amino acids. The peptides are suitable for use in treating illnesses.

公开(公告)号：DE3841736A1

公开(公告)日：1990-07-05

申请号：DE3841736

申请日：1988-12-10

Applicant: BASF AG

Inventor： BACH ALFRED DR ,  STRUBE KARL-HERMANN DR ,  KOERWER WOLFGANG DR

IPC: A61K38/36 ,  A61K38/46 ,  A61K38/48 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C07K14/46 ,  C07K14/75 ,  C12N1/00 ,  C12N1/15 ,  C12N1/21 ,  C12N5/22 ,  C12N9/50 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/57 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12R1/19 ,  C12R1/91

Abstract: Pure glycosylated, partially glycosylated or non-glycosylated polypeptides with the amino acid sequence of ancrod, in which up to 5 amino acid residues can be substituted by residues of other natural amino acids, are suitable for combatting diseases.

公开(公告)号：DE19724980A1

公开(公告)日：1998-12-17

申请号：DE19724980

申请日：1997-06-13

Applicant: BASF AG

Inventor： STEINER GERD DR ,  DULLWEBER UTA DR ,  STARCK DOROTHEA DR ,  BACH ALFRED DR ,  WICKE KARSTEN DR ,  TESCHENDORF HANS-JUERGEN DR ,  GARCIA-LADONA FRANCISCO-JAVI D ,  EMLING FRANZ DR

IPC: A61K31/495 ,  A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/04 ,  A61K31/505 ,  A61K31/55

Abstract: The invention relates to 3-substituted 3,4 dihydro-thieno[2, 3-d] pyrimidine derivatives of formula (I) wherein R and R mean a hydrogen atom or a C1-C4 alkyl group, R represents a phenyl, pyridyl, pyrimidinyl or pyrazinyl group optionally mono- or disubstituted by halogen atoms, C1-C4 alkyl, trifluoromethyl, trifluoromethoxy, hydroxy, C1-C4 alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups, said group being optionally anellated with a benzene nucleus which is optionally mono- or disubstituted by halogen atoms, C1-C4 alkyl, hydroxy, trifluoromethyl, C1-C4 alkoxy, amino, cyano or nitro groups and may contain optionally 1 nitrogen atom, or with a 5 or 6-membered ring which may contain 1-2 oxygen atoms, A represents NH or an oxygen atom, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z represents a nitrogen atom, carbon atom or CH and the bond between Y and Z can also be a double bond, and n is the number 2, 3 or 4. The invention also relates to the physiologically compatible salts of the inventive 3-substituted 3,4 dihydro-thieno[2,3-d] pyrimidine derivatives.

公开(公告)号：DE4425145A1

公开(公告)日：1996-01-18

申请号：DE4425145

申请日：1994-07-15

Applicant: BASF AG

Inventor： HELLENDAHL BEATE DR ,  LANSKY ANNEGRET DR ,  RENDENBACH-MUELLER BEATRICE DR ,  BACH ALFRED DR ,  UNGER LILIANE DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  WICKE CARSTEN DR

IPC: C07D277/22 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/496 ,  A61K31/54 ,  C07D277/20 ,  C07D277/32 ,  C07D277/36 ,  C07D277/42 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D417/12 ,  A61K31/495 ,  C07D401/14

Abstract: The use is disclosed of thiazole and thiadiazole compounds having the formula (I), in which R , A, B and Ar have the meanings given in the description. These compounds have a high affinity to the dopamine D3 receptor and are therefore useful for treating diseases of the central nervous system.

公开(公告)号：DE4041465A1

公开(公告)日：1992-06-25

申请号：DE4041465

申请日：1990-12-22

Applicant: BASF AG

Inventor： STEINER GERD DR ,  BACH ALFRED DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: A61K31/55 ,  A61P25/04 ,  A61P25/06

Abstract: The description relates to the use of 5-cyanomethylene-4-(piperazone-1-yl)-pyrrolo[4,3-e]benzoazepines of formula I, in which R , R and R have the significance given in the specification, for relieving migraine.

公开(公告)号：DE4041463A1

公开(公告)日：1992-06-25

申请号：DE4041463

申请日：1990-12-22

Applicant: BASF AG

Inventor： STEINER GERD DR ,  BACH ALFRED DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D295/155

Abstract: The description relates to the use of 5-cyanomethylene-10-(piperazine-1-yl)-dibenzo[a,d]cycloheptenes of formula (I), in which R , R and R have the significance given in the specification, for relieving migraine.

公开(公告)号：DE19747063A1

公开(公告)日：1999-04-29

申请号：DE19747063

申请日：1997-10-24

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  DULLWEBER UTA DR ,  STARCK DOROTHEA DR ,  STEINER GERD DR ,  BACH ALFRED DR ,  EMLING FRANZ DR ,  GARCIA-LADONA FRANCISCO JAVIER ,  TESCHENDORF HANS-JUERGEN DR ,  WICKE KARSTEN DR

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/00 ,  C07D471/04 ,  A61K31/505

Abstract: 3-Substituted tetrahydropyridopyrimidinone derivatives (I) and their acid salts are new. 3-Substituted tetrahydropyridopyrimidinone derivatives of formula (I) and their acid salts are new. One of X and Y = CH2 and the other = NR ; R = H, 1-6C alkyl, (1-4C alkyl)carbonyl, CO2-tert.-butyl, arylcarbonyl or phenyl-(1-4C alkyl), which may itself be ring-substituted by F, Cl, Br, I, 1-4C alkyl, 1-4C alkoxy, CF3, OH, NH2, CN or NO2; A = 1-10C alkylene or 2-10C alkylene containing one or more Z groups; Z = O, S, NR , cyclopropyl, CO2, CHOH, or a double or triple bond; R = H or 1-4C alkyl; B' = 4-piperidine, 4-(1,2,3,6-tetrahydropyridine), 4-piperazine or one of these rings N-bound to A via a methylene group; Ar = phenyl (optionally substituted by 1-6C alkyl, 1-6C alkoxy, OH, F, Cl, Br, I, CF3, N(R )2, CO2R , CN or phenyl), tetralinyl, indanyl, other condensed aromatic moieties e.g. naphthalinyl (optionally substituted by 1-4C alkyl or 1-4C alkoxy), anthracenyl, or a 5- or 6-membered aromatic heterocycle with 1 or 2 O or N heteroatoms, which can be anellated with other aromatic groups.

公开(公告)号：DE19746612A1

公开(公告)日：1999-04-29

申请号：DE19746612

申请日：1997-10-22

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  DULLWEBER UTA DR ,  STARCK DOROTHEA DR ,  STEINER GERD DR ,  BACH ALFRED DR ,  EMLING FRANZ DR ,  GARCIA-LADONA FRANCISCO JAVIER ,  TESCHENDORF HANS-JUERGEN DR ,  WIECKE KARSTEN DR

IPC: A61K31/428 ,  A61P25/24 ,  A61P43/00 ,  C07D275/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  A61K31/445 ,  A61K31/44 ,  A61K31/425

Abstract: 2-Substituted 1,2-benzisothiazole derivatives (I) and their acid salts are new. 2-Substituted 1,2-benzisothiazole derivatives of formula (I) and their enantiomers, diastereomers, tautomers and acid salts are new. R , R = independently 1-6C alkyl; R , R = independently H, 1-6C alkyl, OH, 1-6C alkoxy, F, Cl, Br, I, CF3, NR R , CO2R , NO2, CN, pyrrolo, or phenyl-(1-4C alkyl), which may itself be ring-substituted by F, Cl, Br, I, 1-4C alkyl, 1-4C alkoxy, CF3, OH, NH2, CN or NO2; R , R = independently H, 1-6C alkyl, benzoyl, CO2-tert.-butyl, (1-4C alkyl)carbonyl or together form a 5- or 6-membered ring, which may contain a second N atom (e.g. piperazinyl); R = H or 1-6C alkyl; A = 1-10C alkylene or 2-10C alkylene containing one or more Z groups; Z = O, S, NR , cyclopropyl, CHOH, or a double or triple bond; B = 4-piperidine, 4-(1,2,3,6-tetrahydropyridine), 4-piperazine or one of these rings N-bound to A via a methylene group; Ar = phenyl (optionally substituted by 1-6C alkyl, 1-6C alkoxy, OH, F, Cl, Br, I, CF3, NR R , CO2R , CN or phenyl), tetralinyl, indanyl, other condensed aromatic moieties e.g. naphthalinyl (optionally substituted by 1-4C alkyl or 1-4C alkoxy), anthracenyl, or a 5- or 6-membered aromatic heterocycle with 1 or 2 O or N heteroatoms, which can be anellated with other aromatic groups.