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1.发明专利
公开(公告)号：CZ153797A3
公开(公告)日：1998-02-18
申请号：CZ153797
申请日：1995-11-25
Applicant: BASF AG
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公开(公告)号：DE4437502A1
公开(公告)日：1995-06-08
申请号：DE4437502
申请日：1994-10-20
Applicant: BASF AG
Inventor： SUBKOWSKI THOMAS DR , SCHWEDEN JUERGEN DR , ECKES PETER DR , HORNBERGER WILFRIED DR
Abstract: New conjugates comprise hirudin covalently bonded to one or more lipophilic cpds. (I) having an octanol-water partition coefft. > 1.8. (I) are bonded to hirudin in the region of aminoacids 27-37, esp. through lysine in position 27 or 33.
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公开(公告)号：CZ245797A3
公开(公告)日：1998-06-17
申请号：CZ245797
申请日：1996-02-12
Applicant: BASF AG
Inventor： BOHM HANS-JOACHIM DR , HOFFKEN HANS WOLFGANG DR , HORNBERGER WILFRIED DR , KOSER STEFAN DR , MACK HELMUT DR , PFEIFFER THOMAS DR , SEITZ WERNER DR , ZIERKE THOMAS DR
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , A61K31/40 , A61K31/445 , A61K31/495
Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.
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公开(公告)号：CZ9702376A3
公开(公告)日：1998-04-15
申请号：CZ237697
申请日：1996-02-06
Applicant: BASF AG
Inventor： SEITZ WERNER DR , MACK HELMUT DR , ZIERKE THOMAS DR , BOHM HANS-JOACHIM DR , HOFFKEN HANS WOLFGANG DR , KOSER STEFAN DR , PFEIFFER THOMAS DR , HORNBERGER WILFRIED DR
CPC classification number: C07K5/0812 , A61K38/00 , C07K5/06026 , C07K5/06034 , C07K5/0606 , C07K5/06078 , C07K5/06113 , C07K5/06191
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公开(公告)号：CZ237697A3
公开(公告)日：1998-04-15
申请号：CZ237697
申请日：1996-02-06
Applicant: BASF AG
Inventor： SEITZ WERNER DR , MACK HELMUT DR , ZIERKE THOMAS DR , BOHM HANS-JOACHIM DR , HOFFKEN HANS WOLFGANG DR , KOSER STEFAN DR , PFEIFFER THOMAS DR , HORNBERGER WILFRIED DR
Abstract: PCT No. PCT/EP96/00472 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24609 PCT Pub. Date Aug. 15, 1996Thrombin inhibitors of the formula where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are suitable for controlling diseases.
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Patent Agency Ranking
公开(公告)号：DE4437604A1
公开(公告)日：1996-04-25
申请号：DE4437604
申请日：1994-10-21
Applicant: BASF AG
Inventor： SCHWEDEN JUERGEN DR , HORNBERGER WILFRIED DR
Abstract: Disclosed are conjugates of a polypeptide or oligopeptide with a low molecular weight lipophilic compound, the peptide and lipophilic group being covalently linked to one another either directly or via a connecting element, with the exception of (a) conjugates in which the peptide component consists of hirudin or peptide structurally derived from hirudin or a peptide derivative with hirudin-like properties, and (b) conjugates whose peptide component has been hydrophobically modified during their biosynthesis.
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公开(公告)号：DE19632773A1
公开(公告)日：1998-02-19
申请号：DE19632773
申请日：1996-08-14
Applicant: BASF AG
Inventor： MACK HELMUT DR , SEITZ WERNER DR , BAUCKE DORIT DR , LANGE UDO DR , HORNBERGER WILFRIED DR , HOEFFKEN HANS WOLFGANG DR , ZIERKE THOMAS DR
IPC: A61K38/00 , A61K38/05 , A61P7/02 , A61P29/00 , A61P35/00 , A61P35/04 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/078
Abstract: Compounds having formula (I) wherein A, B, E and D have the m eanings indicated in the description, are described, in addition to the production thereof. The substances can be used to combat illnesses.
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8.发明专利
公开(公告)号：CZ9701537A3
公开(公告)日：1998-02-18
申请号：CZ153797
申请日：1995-11-25
Applicant: BASF AG
Inventor： BOHM HANS JOACHIM DR , KOSER STEFAN DR , MACK HELMUT DR , PFEIFFER THOMAS DR , SEITZ WERNER DR , HOFFKEN HANS WOLFGANG DR , HORNBERGER WILFRIED DR , ZIERKE THOMAS DR
IPC: A61K38/00 , A61K38/05 , A61P7/02 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/072 , C07K5/087 , A61K38/55
CPC classification number: C07K5/0812 , A61K38/00 , C07K5/06026 , C07K5/06043 , C07K5/06078 , C07K5/06113
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公开(公告)号：DE4103649A1
公开(公告)日：1992-08-13
申请号：DE4103649
申请日：1991-02-07
Applicant: BASF AG
Inventor： SCHMIED BERNHARD DR , HOEFFKEN HANS WOLFGANG DR , HORNBERGER WILFRIED DR , BERNARD HARALD DR
IPC: A61K38/55 , A61K38/00 , A61P7/02 , C07K7/06 , C07K14/815
Abstract: The description relates to peptides of the formula (I), in which X, A -A , Y and W have the meanings given in the description, and their production. The peptides are suitable for combatting diseases.
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公开(公告)号：DE19632772A1
公开(公告)日：1998-02-19
申请号：DE19632772
申请日：1996-08-14
Applicant: BASF AG
Inventor： BAUCKE DORIT DR , LANGE UDO DR , MACK HELMUT DR , PFEIFFER THOMAS DR , SEITZ WERNER DR , ZIERKE THOMAS DR , HORNBERGER WILFRIED DR , HOEFFKEN HANS WOLFGANG DR
IPC: A61K31/40 , A61K31/44 , A61K38/00 , A61K38/05 , A61P1/18 , A61P7/02 , A61P11/02 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D207/22 , C07D211/78 , C07K5/00 , C07K5/02 , C07K5/083 , C07K5/078 , C07D227/06
Abstract: Disclosed are compounds having formula (I) wherein the radicals R, R , R , R , R , R and R , as well as l, m, and n have the meaning indicated in the description, and the production of said compounds. The new compounds can be used to combat illness. Also described are compounds having formula (II) wherein the radicals R, R , R , R , R , R and R , as well as l, m, and n have the meaning indicated in claim 1, and compounds having formula (III) wherein l and R have the meaning indicated in claim 1 and Y is an N protective group, or N-terminal protected or unprotected amino acid or represents H.
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