公开(公告)号：DE19632773A1

公开(公告)日：1998-02-19

申请号：DE19632773

申请日：1996-08-14

Applicant: BASF AG

Inventor： MACK HELMUT DR ,  SEITZ WERNER DR ,  BAUCKE DORIT DR ,  LANGE UDO DR ,  HORNBERGER WILFRIED DR ,  HOEFFKEN HANS WOLFGANG DR ,  ZIERKE THOMAS DR

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/078

Abstract: Compounds having formula (I) wherein A, B, E and D have the m eanings indicated in the description, are described, in addition to the production thereof. The substances can be used to combat illnesses.

公开(公告)号：DE19630082A1

公开(公告)日：1998-01-29

申请号：DE19630082

申请日：1996-07-26

Applicant: BASF AG

Inventor： MACK HELMUT DR ,  PFEIFFER THOMAS DR ,  SEITZ WERNER DR ,  ZIERKE THOMAS DR ,  BALKENHOHL FRIEDHELM DR ,  LANGE UDO DR

IPC: C12P17/04 ,  C07D207/22 ,  C07D401/12 ,  C07D401/04 ,  C07B57/00

Abstract: A process is disclosed for preparing 3-pyrroline-2-carboxylic acid derivatives of formula (I), in which R stands for H, C1-C6-alkyl, benzyl, benzyl substituted at the phenyl radical, allyloxycarbonyl, C1-C6-alkyloxycarbonyl, benzyloxycarbonyl, in which the benzyl radical can be substituted by OCH3 radicals, or for C1-C4-alkylcarbonyl; or R stands for an amino acid radical which can be alkylated or acylated at the nitrogen and is linked by the C-terminal; and R stands for OH, C1-C4-alkyloxy, benzyloxy or an N R group, in which R and R represent independently from each other H, C1-C4-alkyl, benzyl, phenyl or pyridyl, in which the aromatic compounds in R and R can be substituted by up to three identical or different substituents selected from the group composed of methyl, methoxy, hydroxy, cyano or halogen. According to this process, the sulphonic acid radical is eliminated by means of a base from a compound having the formula (II), in which R and R have the above meanings and R stands for C1-C6-alkyl, benzyl, trifluoromethyl, naphthyl or phenyl optionally substituted by radicals from the group composed of methyl, nitro and halogen.

公开(公告)号：DE19632772A1

公开(公告)日：1998-02-19

申请号：DE19632772

申请日：1996-08-14

Applicant: BASF AG

Inventor： BAUCKE DORIT DR ,  LANGE UDO DR ,  MACK HELMUT DR ,  PFEIFFER THOMAS DR ,  SEITZ WERNER DR ,  ZIERKE THOMAS DR ,  HORNBERGER WILFRIED DR ,  HOEFFKEN HANS WOLFGANG DR

IPC: A61K31/40 ,  A61K31/44 ,  A61K38/00 ,  A61K38/05 ,  A61P1/18 ,  A61P7/02 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D207/22 ,  C07D211/78 ,  C07K5/00 ,  C07K5/02 ,  C07K5/083 ,  C07K5/078 ,  C07D227/06

Abstract: Disclosed are compounds having formula (I) wherein the radicals R, R , R , R , R , R and R , as well as l, m, and n have the meaning indicated in the description, and the production of said compounds. The new compounds can be used to combat illness. Also described are compounds having formula (II) wherein the radicals R, R , R , R , R , R and R , as well as l, m, and n have the meaning indicated in claim 1, and compounds having formula (III) wherein l and R have the meaning indicated in claim 1 and Y is an N protective group, or N-terminal protected or unprotected amino acid or represents H.