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公开(公告)号：CZ9801846A3
公开(公告)日：1998-09-16
申请号：CZ184698
申请日：1996-12-11
Applicant: BASF AG
Inventor： AMBERG WILHELM DR , BARLOZZARI TERESA , BERNARD HARALD DR , BUSCHMANN ERNST DR , HAUPT ANDREAS DR , HEGE HANS-GUENTHER DR , JANSSEN BERND DR , KLING ANDREAS DR , LIETZ HELMUT , RITTER KURT DR , ULRICH MARTINA DR , WEYMANN JURGEN DR , ZIERKE THOMAS DR
CPC classification number: A61K38/08
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公开(公告)号：DE4415998A1
公开(公告)日：1995-11-09
申请号：DE4415998
申请日：1994-05-06
Applicant: BASF AG
Inventor： AMBERG WILHELM DR , BERNARD HARALD DR , BUSCHMANN ERNST DR , HAUPT ANDREAS DR , JANITSCHKE LOTHAR DR , JANSSEN BERND DR , KARL ULRICH DR , KLING ANDREAS DR , MUELLER STEFAN DR , POTZOLLI BERND DE DR , RITTER KURT DR , ZIERKE THOMAS DR , THYES MARCO DR
Abstract: Compounds of formula (I) are disclosed, wherein R , R , R , and R have the meanings indicated in the description, as well as a process for the production of these compounds. The compounds are suitable for use as starting material for the synthesis of substances which have anti-tumour properties.
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公开(公告)号：DE4415997A1
公开(公告)日：1995-11-09
申请号：DE4415997
申请日：1994-05-06
Applicant: BASF AG
Inventor： AMBERG WILHELM DR , BERNARD HARALD DR , BUSCHMANN ERNST DR , HAUPT ANDREAS DR , JANITSCHKE LOTHAR DR , JANSSEN BERND DR , KARL ULRICH DR , KLING ANDREAS DR , MUELLER STEFAN DR , POTZOLLI BERND DE DR , RITTER KURT DR , ZIERKE THOMAS DR , THYES MARCO DR
Abstract: Disclosed is the compound Me2Val-Val-MeVal-Pro-Pro-NHBzl. HCl. The compound is produced from Z-Val-Val-MeVal-Pro-OR , wherein Z and R have the meanings indicated in the description. The compound disclosed has anti-neoplastic properties.
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公开(公告)号：CZ184698A3
公开(公告)日：1998-09-16
申请号：CZ184698
申请日：1996-12-11
Applicant: BASF AG
Inventor： AMBERG WILHELM DR , BARLOZZARI TERESA , BERNARD HARALD DR , BUSCHMANN ERNST DR , HAUPT ANDREAS DR , HEGE HANS-GUENTHER DR , JANSSEN BERND DR , KLING ANDREAS DR , LIETZ HELMUT , RITTER KURT DR , ULRICH MARTINA DR , WEYMANN JURGEN DR , ZIERKE THOMAS DR
Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号：CZ24398A3
公开(公告)日：1998-07-15
申请号：CZ24398
申请日：1996-07-12
Applicant: BASF AG
Inventor： AMBERG WILHELM DR , BERNARD HARALD DR , BUSCHMANN ERNST DR , HAUPT ANDREAS DR , JANSSEN BERND DR , KARL ULRICH DR , KLING ANDREAS DR , MULLER STEFAN DR , RITTER KURT DR , ZIERKE THOMAS DR
IPC: C07K1/02 , C07K1/12 , C07K5/06 , C07K5/078 , C07K5/08 , C07K5/083 , C07K5/10 , C07K5/103 , C07K7/06
Abstract: PCT No. PCT/EP96/03073 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05162 PCT Pub. Date Feb. 13, 1997A process for preparing pentapeptides of the formula I where A and R1-R3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II where R1 and R2 have the abovementioned meanings, and eliminating the group -NR1R2 by hydrolysis where appropriate the peptide obtained in this way.
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Patent Agency Ranking
公开(公告)号：CZ326096A3
公开(公告)日：1997-04-16
申请号：CZ326096
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM DR , BERNARD HARALD DR , BUSCHMANN ERNST DR , HAUPT ANDREAS DR , JANITSCHKE LOTHAR DR , JANSSEN BERND DR , KARL ULRICH DR , KLING ANDREAS DR , MULLER STEFAN DR , DE POTZOLLI BERND DR , RITTER KURT DR , THYES MARCO DR , ZIERKE THOMAS DR
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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公开(公告)号：DE4103649A1
公开(公告)日：1992-08-13
申请号：DE4103649
申请日：1991-02-07
Applicant: BASF AG
Inventor： SCHMIED BERNHARD DR , HOEFFKEN HANS WOLFGANG DR , HORNBERGER WILFRIED DR , BERNARD HARALD DR
IPC: A61K38/55 , A61K38/00 , A61P7/02 , C07K7/06 , C07K14/815
Abstract: The description relates to peptides of the formula (I), in which X, A -A , Y and W have the meanings given in the description, and their production. The peptides are suitable for combatting diseases.
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公开(公告)号：CZ288448B6
公开(公告)日：2001-06-13
申请号：CZ326096
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM DR , BERNARD HARALD DR , BUSCHMANN ERNST DR , HAUPT ANDREAS DR , JANITSCHKE LOTHAR DR , MUELLER STEFAN DR , DE POTZOLLI BERND DR , RITTER KURT DR , THYES MARCO DR , ZIERKE THOMAS DR , JANSSEN BERND DR , KARL ULRICH DR , KLING ANDREAS DR
Abstract: In the present invention, there is described pentapeptide hydrochloride of the formula Mei2Val-Val-MeVal-Pro-Pro-NHBz1.HCl, which is present in crystalline form. It is prepared from the compound of the formula Z-Val-Val-MeVal-Pro-ORe1, in which Z represents a benzyloxycarbonyl protecting group, which might be optionally substituted on the phenyl ring and Re1 represents alkyl containing 1 to 5 carbon atoms. In the present invention, there are also described intermediates for preparing the above indicated pentapeptide hydrochloride. The above-described compound exhibits antineoplastic activity.
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公开(公告)号：CZ9800243A3
公开(公告)日：1998-07-15
申请号：CZ24398
申请日：1996-07-12
Applicant: BASF AG
Inventor： AMBERG WILHELM DR , BERNARD HARALD DR , BUSCHMANN ERNST DR , HAUPT ANDREAS DR , JANSSEN BERND DR , KARL ULRICH DR , KLING ANDREAS DR , MULLER STEFAN DR , RITTER KURT DR , ZIERKE THOMAS DR
IPC: C07K1/02 , C07K1/12 , C07K5/078 , C07K5/083 , C07K5/103 , C07K7/06 , C07K5/06 , C07K5/08 , C07K5/10
CPC classification number: C07K7/06 , C07K5/06165 , C07K5/0808 , C07K5/101
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公开(公告)号：CZ9603260A3
公开(公告)日：1997-04-16
申请号：CZ326096
申请日：1995-04-26
Applicant: BASF AG
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