公开(公告)号：JP2002241351A

公开(公告)日：2002-08-28

申请号：JP2002000179

申请日：2002-01-04

Applicant: BASF AG

Inventor： PFEFFINGER JOACHIM ,  HULLMANN MICHAEL ,  HOEHN ARTHUR ,  FUNKE FRANK DR ,  OHLBACH FRANK ,  GERLACH TILL

IPC: C07B61/00 ,  C07C209/48 ,  C07C211/05 ,  C07C211/11 ,  C07C211/14

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a secondary amine in a high yield and selectivity by selecting nitrile using hydrogen in the presence of a catalyst. SOLUTION: In this method for producing a secondary amine represented by general formula (II) (X-CH2-)2NH (II) [X is an alkyl, an alkenyl or a cycloalkyl group] (II), a nitrile represented by general formula (III) X-CN (III) is reacted with hydrogen at 20-250 deg.C under 60-350 bar in the presence of 0.1-5 mass % based on the total amount of Rh and a catalyst on a carrier of a RH-containing catalyst to form a mixture of a primary amine represented by general formula (I) X-CH2-NH2 (I) and the secondary amine represented by general formula (II) (X-CH2-)2NH (II) and at least a part of the primary amine separated from the obtained mixture is returned to the reaction.

公开(公告)号：JP2002226440A

公开(公告)日：2002-08-14

申请号：JP2002000609

申请日：2002-01-07

Applicant: BASF AG

Inventor： PFEFFINGER JOACHIM ,  HULLMANN MICHAEL ,  HOEHN ARTHUR ,  FUNKE FRANK DR ,  OHLBACH FRANK ,  GERLACH TILL

IPC: C07B61/00 ,  C07C209/48 ,  C07C211/11 ,  C07C211/14 ,  C07C213/02 ,  C07C215/08

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a mixture comprising a primary amine and a secondary amine, comprising reacting a nitrile with hydrogen in the presence of a catalyst. SOLUTION: This method for producing the mixture comprising the primary amine of formula (I): X-CH2-NH2 (I) and the secondary amine of formula (II): (X-CH2-)2NH (II) comprises reacting a nitrile of formula (III): X-CN (III) with hydrogen in the presence of a Pd-containing catalyst containing the Pd on a support in an amount of 0.1 to 10 mass % based on the total amount of the catalyst at 50 to 250 deg.C at a pressure of 5 to 350 bar.

公开(公告)号：AU2002310949B2

公开(公告)日：2008-01-31

申请号：AU2002310949

申请日：2002-03-15

Applicant: BASF AG

Inventor： KUSCHE ANDREAS ,  GERLACH TILL ,  KASHAMMER STEFAN ,  HULLMANN MICHAEL ,  HENNINGSEN MICHAEL ,  RUB LOTHAR

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033

Abstract: The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula I in which R 1 and R 2 , independently of one another, are hydrogen, alkyl or cycloalkyl, or R 1 and R 2 together with the carbon atom to which they are bonded are a 5- to 14-membered carbocycle, and R 3 and R 4 , independently of one another, are alkyl or cycloalkyl, by reacting at least one carbonyl compound of the formula II in which R 1 and R 2 have the meanings given above, with at least one morpholine of the formula III in which R 3 and R 4 have the meanings given above, in the presence of hydrogen and at least one metal-containing catalyst, wherein the active component of the catalyst consists essentially of platinum group metals.

公开(公告)号：AU2002310949C1

公开(公告)日：2008-08-07

申请号：AU2002310949

申请日：2002-03-15

Applicant: BASF AG

Inventor： KUSCHE ANDREAS ,  GERLACH TILL ,  KASHAMMER STEFAN ,  HULLMANN MICHAEL ,  HENNINGSEN MICHAEL ,  RUB LOTHAR

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033

Abstract: The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula I in which R 1 and R 2 , independently of one another, are hydrogen, alkyl or cycloalkyl, or R 1 and R 2 together with the carbon atom to which they are bonded are a 5- to 14-membered carbocycle, and R 3 and R 4 , independently of one another, are alkyl or cycloalkyl, by reacting at least one carbonyl compound of the formula II in which R 1 and R 2 have the meanings given above, with at least one morpholine of the formula III in which R 3 and R 4 have the meanings given above, in the presence of hydrogen and at least one metal-containing catalyst, wherein the active component of the catalyst consists essentially of platinum group metals.

公开(公告)号：CA2440518C

公开(公告)日：2010-05-25

申请号：CA2440518

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HULLMANN MICHAEL ,  RUB LOTHAR ,  KASHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/30 ,  C07D295/02 ,  A01N43/84 ,  C07B61/00 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033

Abstract: The invention relates to a method of producing the N-substituted 2,6-dialkyl morpholines of general formula (I), wherein R1 and R2 independently represent hydrogen, alkyl or cycloalkyl, or R1 and R2, together with the carbon atom to which they are bound, represent a 5 to 14 membered carbocyclic compound, and R3 and R4 independently represent alkyl or cycloalkyl. The inventive substances are produced by reacting at least one carbonyl compound of general formula (II), wherein R1 and R2 are defined as above, with at least one morpholine of general formula (III), wherein R3 and R4 are defined as above, in the presence of hydrogen and at least one metal-containing catalyst, the active component of said catalyst substantially consisting of platinum group metals.

公开(公告)号：ES2254686T3

公开(公告)日：2006-06-16

申请号：ES02735133

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HULLMANN MICHAEL ,  RUB LOTHAR ,  KASHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033 ,  A01N43/84

Abstract: Procedimiento para la obtención de 2, 6-dialquilmorfolinas N-substituidas de la fórmula general I en la que R1 y R2 significan, independientemente entre sí, hidrógeno, alquilo o cicloalquilo, o R1 y R2 significan junto con el átomo de carbono, con el que están enlazados, un carbociclo con 5 hasta 14 miembros, y R3 y R4 significan, independientemente entre sí, alquilo o cicloalquilo, mediante reacción de al menos un compuesto de carbonilo de la fórmula general II en la que R3 y R4 tienen los significados anteriormente indicados, en presencia de hidrógeno y de al menos un catalizador metálico, caracterizado porque los componentes activos del catalizador están constituidos esencialmente por metales del grupo del platino.

公开(公告)号：EA006551B1

公开(公告)日：2006-02-24

申请号：EA200300930

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HULLMANN MICHAEL ,  KASHAMMER STEFAN ,  GERLACH TILL ,  RUEB LOTHAR

IPC: C07D265/30 ,  C07D295/023 ,  C07B61/00 ,  C07D295/02 ,  C07D295/03 ,  C07D295/033

Abstract: Визобретенииописываетсяспособполучения N-замещенных 2,6-диалкилморфолиновобщейформулы (I)вкоторой Rи Rнезависимодруготдругапредставляютсобойводород, алкиллибоциклоалкилили Rи Rвместес атомомуглерода, скоторымонисвязаны, образуют 5-14-членныйкарбоцикл, a Rи Rнезависимодруготдругапредставляютсобойалкилилициклоалкил, осуществляемыйвзаимодействиемпоменьшеймереодногокарбонильногосоединенияобщейформулы (II)вкоторой Rи Rимеютуказанныевышезначения, поменьшеймерес однимморфолиномобщейформулы (III)вкоторой Rи Rимеютуказанныевышезначения, вприсутствииводородаи поменьшеймереодногометаллсодержащегокатализатора, отличающийсятем, чтоактивныйкомпоненткатализаторав основномсостоитизметалловплатиновойгруппы.

公开(公告)号：CZ20032468A3

公开(公告)日：2004-03-17

申请号：CZ20032468

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HULLMANN MICHAEL ,  RUB LOTHAR ,  KASHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033 ,  A01N43/84

Abstract: The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula I in which R 1 and R 2 , independently of one another, are hydrogen, alkyl or cycloalkyl, or R 1 and R 2 together with the carbon atom to which they are bonded are a 5- to 14-membered carbocycle, and R 3 and R 4 , independently of one another, are alkyl or cycloalkyl, by reacting at least one carbonyl compound of the formula II in which R 1 and R 2 have the meanings given above, with at least one morpholine of the formula III in which R 3 and R 4 have the meanings given above, in the presence of hydrogen and at least one metal-containing catalyst, wherein the active component of the catalyst consists essentially of platinum group metals.

公开(公告)号：AU2003215639A8

公开(公告)日：2003-09-22

申请号：AU2003215639

申请日：2003-03-07

Applicant: BASF AG

Inventor： HULLMANN MICHAEL ,  ISELBORN STEFAN ,  GERLACH TILL ,  FUNKE FRANK ,  RUDLOFF MARTIN ,  MELDER JOHANN-PETER

IPC: C07D295/02 ,  B01J23/70 ,  B01J23/755 ,  B01J23/78 ,  B01J37/03 ,  B01J37/06 ,  C07B61/00 ,  C07C209/16 ,  C07C209/26 ,  C07C209/60 ,  C07C211/03 ,  C07C211/07 ,  C07C213/02 ,  C07C217/08 ,  C07D295/023

Abstract: Disclosed are catalysts, the catalytically active mass of which contains 22 to 40 percent by weight of oxygen-containing compounds of zirconium, calculated as ZrO 2 , 1 to 30 percent by weight of oxygen-containing compounds of copper, calculated as CuO, 15 to 50 percent by weight of oxygen-containing compounds of nickel, calculated as NiO, the molar ratio between nickel and copper being greater than 1, 15 to 50 percent by weight of oxygen-containing compounds of cobalt, calculated as CoO, and less than 1 percent by weight of an alkali metal, calculated as alkali metal oxide, prior to being treated with hydrogen. Also disclosed is a method for the production of amines by reacting primary and secondary alcohols, aldehydes, or ketones with hydrogen and nitrogen compounds selected from the group ammonia, primary and secondary amines, in the presence of said catalysts at an elevated temperature and an elevated pressure.

公开(公告)号：CA2440518A1

公开(公告)日：2002-09-26

申请号：CA2440518

申请日：2002-03-15

Applicant: BASF AG

Inventor： KUSCHE ANDREAS ,  GERLACH TILL ,  HULLMANN MICHAEL ,  HENNINGSEN MICHAEL ,  RUB LOTHAR ,  KASHAMMER STEFAN

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033 ,  A01N43/84

Abstract: The invention relates to a method of producing the N-substituted 2,6-dialkyl morpholines of general formula (I), wherein R1 and R2 independently represen t hydrogen, alkyl or cycloalkyl, or R1 and R2, together with the carbon atom t o which they are bound, represent a 5 to 14 membered carbocyclic compound, and R3 and R4 independently represent alkyl or cycloalkyl. The inventive substances are produced by reacting at least one carbonyl compound of genera l formula (II), wherein R1 and R2 are defined as above, with at least one morpholine of general formula (III), wherein R3 and R4 are defined as above, in the presence of hydrogen and at least one metal-containing catalyst, the active component of said catalyst substantially consisting of platinum group metals.