公开(公告)号：WO2007071626A2

公开(公告)日：2007-06-28

申请号：PCT/EP2006069777

申请日：2006-12-15

Applicant: BASF AG ,  ERNST MARTIN ,  KUSCHE ANDREAS ,  HEYDRICH GUNNAR ,  GRAFMANS HORST ,  EVERS HOLGER ,  MELDER JOHANN-PETER ,  MEISSNER HARALD ,  FREUND TORSTEN

Inventor： ERNST MARTIN ,  KUSCHE ANDREAS ,  HEYDRICH GUNNAR ,  GRAFMANS HORST ,  EVERS HOLGER ,  MELDER JOHANN-PETER ,  MEISSNER HARALD ,  FREUND TORSTEN

IPC: C07C231/12 ,  C07C237/06

CPC classification number: C07C231/14 ,  Y02P20/582 ,  C07C237/06

Abstract: The invention relates to a method for producing aminoalkane acid amines by reacting cyanoalkane acid esters with a) ammonia or an amine and b) hydrogen in the presence of a catalyst, the reaction with component b) being started simultaneously or a maximum of 100 minutes after starting to react the cyanoalkane acid ester with component a).

Abstract translation: 本发明涉及一种用于Aminoalkansäureamiden的制备方法通过用）氨或胺Cyanalkansäureestern反应，和b）在催化剂的存在下，氢气其中Cyanalkansäureesters的执行开始后在同一时间与组分b）的反应或不晚于最大100分钟 从组件a）开始。

公开(公告)号：CA2440518C

公开(公告)日：2010-05-25

申请号：CA2440518

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HULLMANN MICHAEL ,  RUB LOTHAR ,  KASHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/30 ,  C07D295/02 ,  A01N43/84 ,  C07B61/00 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033

Abstract: The invention relates to a method of producing the N-substituted 2,6-dialkyl morpholines of general formula (I), wherein R1 and R2 independently represent hydrogen, alkyl or cycloalkyl, or R1 and R2, together with the carbon atom to which they are bound, represent a 5 to 14 membered carbocyclic compound, and R3 and R4 independently represent alkyl or cycloalkyl. The inventive substances are produced by reacting at least one carbonyl compound of general formula (II), wherein R1 and R2 are defined as above, with at least one morpholine of general formula (III), wherein R3 and R4 are defined as above, in the presence of hydrogen and at least one metal-containing catalyst, the active component of said catalyst substantially consisting of platinum group metals.

公开(公告)号：ES2254686T3

公开(公告)日：2006-06-16

申请号：ES02735133

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HULLMANN MICHAEL ,  RUB LOTHAR ,  KASHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033 ,  A01N43/84

Abstract: Procedimiento para la obtención de 2, 6-dialquilmorfolinas N-substituidas de la fórmula general I en la que R1 y R2 significan, independientemente entre sí, hidrógeno, alquilo o cicloalquilo, o R1 y R2 significan junto con el átomo de carbono, con el que están enlazados, un carbociclo con 5 hasta 14 miembros, y R3 y R4 significan, independientemente entre sí, alquilo o cicloalquilo, mediante reacción de al menos un compuesto de carbonilo de la fórmula general II en la que R3 y R4 tienen los significados anteriormente indicados, en presencia de hidrógeno y de al menos un catalizador metálico, caracterizado porque los componentes activos del catalizador están constituidos esencialmente por metales del grupo del platino.

公开(公告)号：CZ304041B6

公开(公告)日：2013-09-04

申请号：CZ20032468

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HUELLMANN MICHAEL ,  RUEB LOTHAR ,  KOSHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/30 ,  C07D295/023 ,  A01N43/84 ,  C07B61/00 ,  C07D295/02 ,  C07D295/027 ,  C07D295/03 ,  C07D295/033

Abstract: Zpusob prípravy N-substituovaných 2,6-dialkylmorfolinu obecného vzorce I, ve kterém R.sup.1.n., R.sup.2.n., R.sup.3.n. a R.sup.4.n. mají význam vysvetlený v popise, reakcí nejméne jedné karbonylové slouceniny obecného vzorce II s nejméne jedním morfolinem obecného vzorce III za prítomnosti vodíku a katalyzátoru obsahujícího nejméne jeden kov, ve kterém se aktivní slozka katalyzátoru skládá hlavne z kovu skupiny platiny.

公开(公告)号：AU2002310949B2

公开(公告)日：2008-01-31

申请号：AU2002310949

申请日：2002-03-15

Applicant: BASF AG

Inventor： KUSCHE ANDREAS ,  GERLACH TILL ,  KASHAMMER STEFAN ,  HULLMANN MICHAEL ,  HENNINGSEN MICHAEL ,  RUB LOTHAR

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033

Abstract: The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula I in which R 1 and R 2 , independently of one another, are hydrogen, alkyl or cycloalkyl, or R 1 and R 2 together with the carbon atom to which they are bonded are a 5- to 14-membered carbocycle, and R 3 and R 4 , independently of one another, are alkyl or cycloalkyl, by reacting at least one carbonyl compound of the formula II in which R 1 and R 2 have the meanings given above, with at least one morpholine of the formula III in which R 3 and R 4 have the meanings given above, in the presence of hydrogen and at least one metal-containing catalyst, wherein the active component of the catalyst consists essentially of platinum group metals.

公开(公告)号：SI1373232T1

公开(公告)日：2006-04-30

申请号：SI200230240

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HUELLMANN MICHAEL ,  RUEB LOTHAR ,  KAESHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/30 ,  C07D295/00 ,  A01N43/00 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033

公开(公告)号：BR0208063A

公开(公告)日：2004-03-02

申请号：BR0208063

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HUELLMANN MICHAEL ,  LOTHAR RUEB ,  KOSHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033 ,  A01N43/84

Abstract: The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula I in which R 1 and R 2 , independently of one another, are hydrogen, alkyl or cycloalkyl, or R 1 and R 2 together with the carbon atom to which they are bonded are a 5- to 14-membered carbocycle, and R 3 and R 4 , independently of one another, are alkyl or cycloalkyl, by reacting at least one carbonyl compound of the formula II in which R 1 and R 2 have the meanings given above, with at least one morpholine of the formula III in which R 3 and R 4 have the meanings given above, in the presence of hydrogen and at least one metal-containing catalyst, wherein the active component of the catalyst consists essentially of platinum group metals.

公开(公告)号：SK286718B6

公开(公告)日：2009-04-06

申请号：SK11412003

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HULLMANN MICHAEL ,  RUB LOTHAR ,  KASHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/00 ,  C07D265/30 ,  C07B61/00 ,  C07D295/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033

Abstract: The invention relates to a method of producing the N-substituted 2,6-dialkyl morpholines of general formula (I), wherein R1 and R2 independently represent hydrogen, alkyl or cycloalkyl, or R1 and R2 , together with the carbon atom to witch they are bound, represent a 5 to 14 membered carbocyclic compound, and R3 and R4 independently represent alkyl or cycloalkyl. The inventive substances are produced by reacting at least one carbonyl compound of general formula (II) with at least one morpholine of general formula (III) in the presence of hydrogen and at least one metal-containing catalyst, the active component of said catalyst substantially consisting of platinum group metals and essentially no silver.

公开(公告)号：DE102005060803A1

公开(公告)日：2007-06-28

申请号：DE102005060803

申请日：2005-12-20

Applicant: BASF AG

Inventor： ERNST MARTIN ,  KUSCHE ANDREAS ,  HEYDRICH GUNNAR ,  GRAFMANS HORST ,  EVERS HOLGER ,  MELDER JOHANN-PETER ,  MEISNER HARALD ,  FREUND TORSTEN

IPC: C07C231/06

Abstract: Preparation of aminoalkanoic acid amide comprises reaction of cyanoalkanoic acid ester with (a) at least a mol-equivalent of ammonia or amine, and (b) hydrogen in the presence of catalyst, at increased pressure, where optionally the formed intermediate stages are not isolated and the reaction with (b) takes place simultaneously or less than 100 minutes, after the beginning of the reaction of cyanoalkanoic acid ester with (a).

公开(公告)号：SK11412003A3

公开(公告)日：2004-02-03

申请号：SK11412003

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HULLMANN MICHAEL ,  RUB LOTHAR ,  KASHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033 ,  A01N43/84

Abstract: The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula I in which R 1 and R 2 , independently of one another, are hydrogen, alkyl or cycloalkyl, or R 1 and R 2 together with the carbon atom to which they are bonded are a 5- to 14-membered carbocycle, and R 3 and R 4 , independently of one another, are alkyl or cycloalkyl, by reacting at least one carbonyl compound of the formula II in which R 1 and R 2 have the meanings given above, with at least one morpholine of the formula III in which R 3 and R 4 have the meanings given above, in the presence of hydrogen and at least one metal-containing catalyst, wherein the active component of the catalyst consists essentially of platinum group metals.