公开(公告)号：CZ20032468A3

公开(公告)日：2004-03-17

申请号：CZ20032468

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HULLMANN MICHAEL ,  RUB LOTHAR ,  KASHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033 ,  A01N43/84

Abstract: The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula I in which R 1 and R 2 , independently of one another, are hydrogen, alkyl or cycloalkyl, or R 1 and R 2 together with the carbon atom to which they are bonded are a 5- to 14-membered carbocycle, and R 3 and R 4 , independently of one another, are alkyl or cycloalkyl, by reacting at least one carbonyl compound of the formula II in which R 1 and R 2 have the meanings given above, with at least one morpholine of the formula III in which R 3 and R 4 have the meanings given above, in the presence of hydrogen and at least one metal-containing catalyst, wherein the active component of the catalyst consists essentially of platinum group metals.

公开(公告)号：CA2440518A1

公开(公告)日：2002-09-26

申请号：CA2440518

申请日：2002-03-15

Applicant: BASF AG

Inventor： KUSCHE ANDREAS ,  GERLACH TILL ,  HULLMANN MICHAEL ,  HENNINGSEN MICHAEL ,  RUB LOTHAR ,  KASHAMMER STEFAN

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033 ,  A01N43/84

Abstract: The invention relates to a method of producing the N-substituted 2,6-dialkyl morpholines of general formula (I), wherein R1 and R2 independently represen t hydrogen, alkyl or cycloalkyl, or R1 and R2, together with the carbon atom t o which they are bound, represent a 5 to 14 membered carbocyclic compound, and R3 and R4 independently represent alkyl or cycloalkyl. The inventive substances are produced by reacting at least one carbonyl compound of genera l formula (II), wherein R1 and R2 are defined as above, with at least one morpholine of general formula (III), wherein R3 and R4 are defined as above, in the presence of hydrogen and at least one metal-containing catalyst, the active component of said catalyst substantially consisting of platinum group metals.

公开(公告)号：AU2004297004B2

公开(公告)日：2010-04-22

申请号：AU2004297004

申请日：2004-12-14

Applicant: BASF AG

Inventor： RUB LOTHAR ,  NOACK REINER ,  PALM CLEMENS

IPC: C07C45/74 ,  C07C47/24

Abstract: The invention relates to a method for producing 2,3-cis-substituted 2-aryl propenals by condensing a 2-aryl acetaldehyde I with a non-enolizable aldehyde compound II in the presence of a base. The inventive method is characterized in that the reaction is carried out in a solvent mixture comprising at least one water-miscible organic solvent and water at a volume ratio V solvent :V water ranging between 10:1 and 0.5:1.

公开(公告)号：AU2002310949C1

公开(公告)日：2008-08-07

申请号：AU2002310949

申请日：2002-03-15

Applicant: BASF AG

Inventor： KUSCHE ANDREAS ,  GERLACH TILL ,  KASHAMMER STEFAN ,  HULLMANN MICHAEL ,  HENNINGSEN MICHAEL ,  RUB LOTHAR

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033

Abstract: The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula I in which R 1 and R 2 , independently of one another, are hydrogen, alkyl or cycloalkyl, or R 1 and R 2 together with the carbon atom to which they are bonded are a 5- to 14-membered carbocycle, and R 3 and R 4 , independently of one another, are alkyl or cycloalkyl, by reacting at least one carbonyl compound of the formula II in which R 1 and R 2 have the meanings given above, with at least one morpholine of the formula III in which R 3 and R 4 have the meanings given above, in the presence of hydrogen and at least one metal-containing catalyst, wherein the active component of the catalyst consists essentially of platinum group metals.

公开(公告)号：AU2002310949B2

公开(公告)日：2008-01-31

申请号：AU2002310949

申请日：2002-03-15

Applicant: BASF AG

Inventor： KUSCHE ANDREAS ,  GERLACH TILL ,  KASHAMMER STEFAN ,  HULLMANN MICHAEL ,  HENNINGSEN MICHAEL ,  RUB LOTHAR

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033

Abstract: The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula I in which R 1 and R 2 , independently of one another, are hydrogen, alkyl or cycloalkyl, or R 1 and R 2 together with the carbon atom to which they are bonded are a 5- to 14-membered carbocycle, and R 3 and R 4 , independently of one another, are alkyl or cycloalkyl, by reacting at least one carbonyl compound of the formula II in which R 1 and R 2 have the meanings given above, with at least one morpholine of the formula III in which R 3 and R 4 have the meanings given above, in the presence of hydrogen and at least one metal-containing catalyst, wherein the active component of the catalyst consists essentially of platinum group metals.

公开(公告)号：SK286718B6

公开(公告)日：2009-04-06

申请号：SK11412003

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HULLMANN MICHAEL ,  RUB LOTHAR ,  KASHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/00 ,  C07D265/30 ,  C07B61/00 ,  C07D295/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033

Abstract: The invention relates to a method of producing the N-substituted 2,6-dialkyl morpholines of general formula (I), wherein R1 and R2 independently represent hydrogen, alkyl or cycloalkyl, or R1 and R2 , together with the carbon atom to witch they are bound, represent a 5 to 14 membered carbocyclic compound, and R3 and R4 independently represent alkyl or cycloalkyl. The inventive substances are produced by reacting at least one carbonyl compound of general formula (II) with at least one morpholine of general formula (III) in the presence of hydrogen and at least one metal-containing catalyst, the active component of said catalyst substantially consisting of platinum group metals and essentially no silver.

公开(公告)号：EA010925B1

公开(公告)日：2008-12-30

申请号：EA200601090

申请日：2004-12-14

Applicant: BASF AG

Inventor： NOACK REINER ,  RUB LOTHAR ,  PALM CLEMENS

IPC: C07C45/74 ,  C07C47/24

Abstract: Настоящееизобретениеотноситсяк способуполучения 2,3-Е-замещенных 2-арилпропеналейконденсацией 2-арилацетальдегида I снеспособнымк образованиюэноловальдегиднымсоединением II вприсутствииоснования, которыйзаключаетсяв проведенииреакциив смесирастворителей, включающейпоменьшеймереодинсмешиваемыйс водойорганическийрастворительи водув объемномсоотношении V:Vот 10:1 до 0,5:1.

公开(公告)号：SK11412003A3

公开(公告)日：2004-02-03

申请号：SK11412003

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HULLMANN MICHAEL ,  RUB LOTHAR ,  KASHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/30 ,  C07B61/00 ,  C07D295/02 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033 ,  A01N43/84

Abstract: The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula I in which R 1 and R 2 , independently of one another, are hydrogen, alkyl or cycloalkyl, or R 1 and R 2 together with the carbon atom to which they are bonded are a 5- to 14-membered carbocycle, and R 3 and R 4 , independently of one another, are alkyl or cycloalkyl, by reacting at least one carbonyl compound of the formula II in which R 1 and R 2 have the meanings given above, with at least one morpholine of the formula III in which R 3 and R 4 have the meanings given above, in the presence of hydrogen and at least one metal-containing catalyst, wherein the active component of the catalyst consists essentially of platinum group metals.

公开(公告)号：CA2440518C

公开(公告)日：2010-05-25

申请号：CA2440518

申请日：2002-03-15

Applicant: BASF AG

Inventor： HENNINGSEN MICHAEL ,  KUSCHE ANDREAS ,  HULLMANN MICHAEL ,  RUB LOTHAR ,  KASHAMMER STEFAN ,  GERLACH TILL

IPC: C07D265/30 ,  C07D295/02 ,  A01N43/84 ,  C07B61/00 ,  C07D295/023 ,  C07D295/03 ,  C07D295/033

Abstract: The invention relates to a method of producing the N-substituted 2,6-dialkyl morpholines of general formula (I), wherein R1 and R2 independently represent hydrogen, alkyl or cycloalkyl, or R1 and R2, together with the carbon atom to which they are bound, represent a 5 to 14 membered carbocyclic compound, and R3 and R4 independently represent alkyl or cycloalkyl. The inventive substances are produced by reacting at least one carbonyl compound of general formula (II), wherein R1 and R2 are defined as above, with at least one morpholine of general formula (III), wherein R3 and R4 are defined as above, in the presence of hydrogen and at least one metal-containing catalyst, the active component of said catalyst substantially consisting of platinum group metals.

公开(公告)号：ZA200605777B

公开(公告)日：2008-06-25

申请号：ZA200605777

申请日：2006-07-13

Applicant: BASF AG

Inventor： NOACK REINER ,  RUB LOTHAR ,  PALM CLEMENS

IPC: C07C20090101 ,  C07C45/74 ,  C07C47/24

Abstract: The invention relates to a method for producing 2,3-cis-substituted 2-aryl propenals by condensing a 2-aryl acetaldehyde I with a non-enolizable aldehyde compound II in the presence of a base. The inventive method is characterized in that the reaction is carried out in a solvent mixture comprising at least one water-miscible organic solvent and water at a volume ratio V solvent :V water ranging between 10:1 and 0.5:1.