公开(公告)号：DE3226863A1

公开(公告)日：1983-04-07

申请号：DE3226863

申请日：1982-07-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DIPL CHEM DR ,  MUELLER JOSEF DIPL CHEM DR ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT DIPL ,  HEGE HANS-GUENTHER DIPL CHEM D ,  MUELLER CLAUS D DR ,  GRIES JOSEF DR ,  LENKE DIETER PROF DR ,  PHILIPSBORN GERDA VON DR ,  RASCHACK MANFRED DR

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C97/10 ,  A61K31/135 ,  A61K31/395 ,  C07D295/10

Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

公开(公告)号：DE3108076A1

公开(公告)日：1982-09-16

申请号：DE3108076

申请日：1981-03-04

Applicant: BASF AG

Inventor： MUELLER JOSEF DIPL CHEM DR ,  WIERSDORFF WALTER-WIELANT DIPL ,  KIRSCHENLOHR WERNER DIPL CHEM ,  SCHWANTJE GERD DIPL CHEM DR

IPC: B01J27/00 ,  C07B61/00 ,  C07C45/00 ,  C07C45/46 ,  C07C49/825 ,  C07C67/00

Abstract: o-Acylphenols and p-acylphenols are prepared by reacting phenol with an acid halide and aluminum chloride, using a halobenzene as the solvent, at from 15 DEG to 55 DEG C. and then at from 55 DEG and 200 DEG C. The compounds obtainable by the process of the invention are valuable starting materials for the preparation of drugs, pesticides and dyes.

公开(公告)号：DE3206660A1

公开(公告)日：1983-09-01

申请号：DE3206660

申请日：1982-02-25

Applicant: BASF AG

Inventor： MUELLER JOSEF DIPL CHEM DR ,  WIERSDORFF WALTER-WIELANT DIPL ,  KIRSCHENLOHR WERNER DIPL CHEM ,  SCHWANTJE GERD DIPL CHEM DR

IPC: C07C231/00 ,  C07C67/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/02 ,  C07C233/13 ,  C07C103/34 ,  C07C103/30

Abstract: 1. A process for the preparation of an o-acylaminomethylbenzyl halide of the formula (I) see diagramm : EP0087676,P5,F3 where X is halogen and R**1 is an aliphatic or aromatic radical, wherein an o-aminomethylbenzyl alkyl ether of the formula (II) see diagramm : EP0087676,P5,F4 where R**2 is alkyl, is reacted with an acylating agent to give the corresponding acylaminomethylbenzyl alkyl ether, and the latter is reacted with an aqueous hydrohalic acid to give the halide (I).