公开(公告)号：DE3762970D1

公开(公告)日：1990-07-05

申请号：DE3762970

申请日：1987-01-03

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ DR ,  SCHMIED BERNHARD DR ,  KROPP RUDOLF ,  BALDINGER VERENA DR ,  GRIES JOSEF DR ,  LEHMANN HANS DIETER PROF DR ,  RUEBSAMEN KLAUS DR ,  TRAUT MARTIN DR

IPC: C07D237/00 ,  A61K31/50 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D403/04 ,  C07D403/10

公开(公告)号：DE3361670D1

公开(公告)日：1986-02-13

申请号：DE3361670

申请日：1983-04-05

Applicant: BASF AG

Inventor： OSTERSEHLT BERND DR ,  FRANKE ALBRECHT DR ,  FRICKEL FRITZ-FRIEDER DR ,  THYES MARCO DR ,  FRIEDRICH LUDWIG DR ,  GRIES JOSEF DR ,  LENKE DIETER DR

IPC: C07D405/12 ,  A61K31/415 ,  A61P1/04 ,  A61P43/00 ,  C07D233/61 ,  C07D521/00

公开(公告)号：AT13885T

公开(公告)日：1985-07-15

申请号：AT81110719

申请日：1981-12-23

Applicant: BASF AG

Inventor： THIEME PETER C DR ,  STEINER GERD DR ,  ROHR WOLFGANG DR ,  LENKE DIETER DR ,  GRIES JOSEF DR ,  WEIFENBACH HARALD DR ,  TESCHENDORF HANS-JUERGEN DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST DR

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/496 ,  A61P9/02 ,  A61P11/00 ,  A61P25/20 ,  C07D231/12 ,  C07D233/60 ,  C07D233/61 ,  C07D271/10 ,  C07D295/06 ,  C07D295/067 ,  C07D295/096 ,  C07D521/00

公开(公告)号：DE3163823D1

公开(公告)日：1984-07-05

申请号：DE3163823

申请日：1981-03-11

Applicant: BASF AG

Inventor： MAY HANS-JOACHIM DR ,  LENKE DIETER DR ,  GRIES JOSEF DR ,  TESCHENDORF HANS-JUERGEN DR ,  WORSTMANN WOLFGANG DR

IPC: C07D409/06 ,  A61K31/33 ,  A61K31/415 ,  A61K31/465 ,  A61K31/47 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06

Abstract: 1-Aroyl-2-phenylamino-2-imidazolines of the general formula where R1 and R2 are identical or different and each is chlorine, bromine, fluorine, methyl, ethyl, methoxy, trifluoromethyl or cyano, R3 has the meanings given for R1 and R2 or is hydrogen and Ar is an unsubstituted or substituted monocyclic or bicyclic heteroaromatic radical containing 1, 2 or 3 nitrogen and/or oxygen and/or sulfur atoms, their salts with physiologically tolerated acids, their preparation, and drugs containing these compounds. The compounds have, inter alia, a blood pressure-reducing action.

公开(公告)号：DE3061907D1

公开(公告)日：1983-03-17

申请号：DE3061907

申请日：1980-08-21

Applicant: BASF AG

Inventor： STEINER GERD DR ,  GRIES JOSEF DR ,  LENKE DIETER DR

IPC: C07D403/04 ,  A61K31/50 ,  A61P9/12 ,  C07D521/00

公开(公告)号：DE3061518D1

公开(公告)日：1983-02-03

申请号：DE3061518

申请日：1980-10-18

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DR ,  THIEME PETER C DR ,  FRANKE ALBRECHT DR ,  THEOBALD HANS DR ,  LENKE DIETER DR ,  GRIES JOSEF DR

IPC: A61K31/42 ,  A61P9/00 ,  A61P9/12 ,  A61P25/02 ,  C07C43/12 ,  C07C45/61 ,  C07C45/64 ,  C07C45/70 ,  C07D261/08 ,  C07F9/653

Abstract: Novel aminopropanol derivatives of 5-(2-hydroxystyryl)-isoxazole and their addition salts with acids, their preparation, pharmaceutical formulations containing these compounds, and their use in the treatment of hypertonia, coronary heart disease and cardiac arrhythmias.

公开(公告)号：DE2818999A1

公开(公告)日：1979-11-15

申请号：DE2818999

申请日：1978-04-29

Applicant: BASF AG

Inventor： THIEME PETER DR ,  FRICKEL FRITZ-FRIEDER DR ,  THEOBALD HANS DR ,  FRANKE ALBRECHT DR ,  LENKE HANS-DIETER PROF DR ,  GRIES JOSEF DR

IPC: A61K31/41 ,  A61K31/42 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P25/02 ,  C07D261/08

Abstract: Alkylamino-propanol derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazole, of the general formula where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and R' is alkyl of 1 to 4 carbon atoms, and their addition salts with physiologically acceptable acids, their preparation, and pharmaceutical formulations which contain these compounds and which can be used as valuable drugs in the treatment of hypertonia, coronary diseases of the heart and cardiac arrhythmias.

公开(公告)号：ES2054650T3

公开(公告)日：1994-08-16

申请号：ES87117946

申请日：1987-12-04

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  BALDINGER VERENA DR ,  RUEBSAMEN KLAUS DR ,  GRIES JOSEF DR

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61K31/36 ,  A61P1/04 ,  A61P3/00 ,  A61P9/00 ,  A61P11/00 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C253/30 ,  C07C255/32 ,  C07C255/33 ,  C07C255/35 ,  C07C255/37 ,  C07C255/42 ,  C07C255/53 ,  C07C255/58 ,  C07D317/50 ,  C07D317/60 ,  C07D319/08 ,  C07D319/18 ,  C07D321/00

Abstract: Basic-substituted phenylacetonitriles of the formula I … … in which… R to R and n have the meaning given in the description, are suitable for combating diseases.

公开(公告)号：DE3871012D1

公开(公告)日：1992-06-17

申请号：DE3871012

申请日：1988-07-23

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  SCHLECKER RAINER DR ,  GRIES JOSEF DR ,  VON PHILIPSBORN GERDA DR ,  UNGER LILIANE DR

IPC: A61K31/135 ,  A61P9/06 ,  A61P25/02

Abstract: New therapeutic agents for oral or parenteral use contain, in addn. to usual galenical adjuvant, 14-1400 mg. of either (S) or (R)-propafenone (I) alone.

公开(公告)号：AT75938T

公开(公告)日：1992-05-15

申请号：AT88111911

申请日：1988-07-23

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  SCHLECKER RAINER DR ,  GRIES JOSEF DR ,  VON PHILIPSBORN GERDA DR ,  UNGER LILIANE DR

IPC: A61K31/135 ,  A61P9/06 ,  A61P25/02