公开(公告)号：DE59609923D1

公开(公告)日：2003-01-09

申请号：DE59609923

申请日：1996-09-30

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  ROSENBERG JOERG ,  NEUMANN JOERG ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/277 ,  A61K47/24 ,  A61K47/26 ,  A61K47/30

Abstract: The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients,A) 10-90% by weight of a melt-processable, water-soluble polymer,B) 5-85% by weight of isomalt, andC) 0-5% by weight of lecithin,where the total of all the ingredients is to be equal to 100% by weight.

公开(公告)号：DK0854707T3

公开(公告)日：2002-12-16

申请号：DK96934494

申请日：1996-09-30

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  ROSENBERG JOERG ,  NEUMANN JOERG ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/277 ,  A61K47/24 ,  A61K47/26 ,  A61K47/30

Abstract: The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients,A) 10-90% by weight of a melt-processable, water-soluble polymer,B) 5-85% by weight of isomalt, andC) 0-5% by weight of lecithin,where the total of all the ingredients is to be equal to 100% by weight.

公开(公告)号：BR9810851A

公开(公告)日：2000-07-25

申请号：BR9810851

申请日：1998-07-21

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  NEUMANN JOERG ,  LIEPOLD BERND ,  ROSENBERG JOERG ,  BERNDL GUNTHER ,  BREITENBACH JOERG ,  VOLLGRAF CHRISTIANE

IPC: A61K9/20 ,  A61K31/192 ,  A61K47/02 ,  A61K47/32 ,  A61P29/00 ,  A61K31/19

Abstract: A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm3.

公开(公告)号：MX9801988A

公开(公告)日：1998-08-30

申请号：MX9801988

申请日：1998-03-13

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  ROSENBERG JOERG ,  NEUMANN JOERG ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/277 ,  A61K47/24 ,  A61K47/26 ,  A61K47/30

Abstract: La presente invencion se refiere a las formas de medicamentos solidos obtenibles por extrusion con el posterior formado de una masa fundida sin solvente, que contiene, además de uno o más ingredientes activos, A) 2-90% en peso de un polímero procesable por fusion, soluble en agua, B) 5-89-9% en peso de isomalta, y C) 0-5% en peso de lecitina, en donde el total de todos los ingredientes es igual a 100% en peso.

公开(公告)号：BG102346A

公开(公告)日：1998-10-30

申请号：BG10234698

申请日：1998-03-24

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  ROSENBERG JOERG ,  NEUMANN JOERG ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/277 ,  A61K47/24 ,  A61K47/26 ,  A61K47/30

Abstract: The solid medicamentous forms are produced by the extrusionand formulation of a smelt containing no solvent, and includingone or more of the following active substances, in wt.%: from 2 to90 thermoplastically treatable water soluble polymer, from 5 to89.9 isomalt and from 0 to 5 lecythin. The sum of the content ofall the substances should be 100 wt.%.8 claims

公开(公告)号：CA2208495A1

公开(公告)日：1997-12-20

申请号：CA2208495

申请日：1997-06-17

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  DIENER RALPH ,  SIMON DIRK ,  ROSENBERG JOERG ,  NEUMANN JOERG ,  ZEIDLER JUERGEN

IPC: A61K31/19 ,  A61K9/16 ,  A61K31/00 ,  B01J19/00 ,  C07C51/41 ,  C07C57/30 ,  C07C229/26 ,  A61K31/185 ,  A61K31/192 ,  A61K31/40 ,  A61K31/405 ,  A61K31/41 ,  A61K31/60

Abstract: A process for preparing salts of pharmaceutical active substances which have acidic groups by reacting the carboxylic acids with a base in the melt, wherein the acids are reacted with at least the stoichiometric amount of a base in an extruder.

公开(公告)号：AU748772B2

公开(公告)日：2002-06-13

申请号：AU8632298

申请日：1998-07-21

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  NEUMANN JOERG ,  LIEPOLD BERND ,  ROSENBERG JOERG ,  BERNDL GUNTHER ,  BREITENBACH JOERG ,  VOLLGRAF CHRISTIANE

IPC: A61K9/20 ,  A61K31/192 ,  A61K47/02 ,  A61K47/32 ,  A61P29/00 ,  A61K31/19

Abstract: A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm3.

公开(公告)号：ZA9608130B

公开(公告)日：1998-03-27

申请号：ZA9608130

申请日：1996-09-27

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  ROSENBERG JOERG ,  NEUMANN JOERG ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/277 ,  A61K47/24 ,  A61K47/26 ,  A61K47/30 ,  A61K ,  A61J

CPC classification number: A61K9/2027 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2095 ,  A61K31/277

公开(公告)号：NO981394D0

公开(公告)日：1998-03-27

申请号：NO981394

申请日：1998-03-27

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  ROSENBERG JOERG ,  NEUMANN JOERG ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/277 ,  A61K47/24 ,  A61K47/26 ,  A61K47/30 ,  A61K

Abstract: The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients,A) 10-90% by weight of a melt-processable, water-soluble polymer,B) 5-85% by weight of isomalt, andC) 0-5% by weight of lecithin,where the total of all the ingredients is to be equal to 100% by weight.

公开(公告)号：AT228355T

公开(公告)日：2002-12-15

申请号：AT96934494

申请日：1996-09-30

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  ROSENBERG JOERG ,  NEUMANN JOERG ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/277 ,  A61K47/24 ,  A61K47/26 ,  A61K47/30

Abstract: The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients,A) 10-90% by weight of a melt-processable, water-soluble polymer,B) 5-85% by weight of isomalt, andC) 0-5% by weight of lecithin,where the total of all the ingredients is to be equal to 100% by weight.