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    New 2,10-diazanthracene derivs., useful in e.g. plant protection
    4.
    发明专利
    New 2,10-diazanthracene derivs., useful in e.g. plant protection 未知

    公开(公告)号：DE19509351A1

    公开(公告)日：1995-10-05

    申请号：DE19509351

    申请日：1995-03-15

    Applicant: BASF AG

    Inventor： FUCHS EBERHARD DR ,  WITZEL TOM DR ,  KRACK GERHARD DR ,  WALKER NIGEL DR

    IPC: C07D471/04

    Abstract: 1,2,3,4,4a,9,9a,10-octahydro-2,10-diazaanthracene cpds. of formula (I) are new: Q = a gp. of formula (i), R -R = H, 1-20C alkyl, 2-20C alkenyl, 3-8C cycloalkyl, 3-8C cycloalkenyl, phenyl, 7-20C alkylphenyl, 7-20C phenylalkyl, OH, 1-20C alkoxy, phenoxy, amino, 1-20C alkylamino, phenylamino, 1-20C dialkylamino, phenyl(1-20C) alkylamino, diphenylamino, halo or NO2, provided that R and/or R are not halo and R , R , R are not simultaneously H (sic).

    New peptide(s) of TNF agonists and antagonists - used for treating neoplastic and autoimmune disease, infection, inflammation and transplant rejection
    5.
    发明专利
    New peptide(s) of TNF agonists and antagonists - used for treating neoplastic and autoimmune disease, infection, inflammation and transplant rejection 未知

    公开(公告)号：DE4041188A1

    公开(公告)日：1992-06-25

    申请号：DE4041188

    申请日：1990-12-21

    Applicant: BASF AG

    Inventor： BOEHM HANS-JOACHIM DR ,  DAUM LOTHAR DR ,  HAUPT ANDREAS DR ,  PETTIG DAGMAR DR ,  WALKER NIGEL DR ,  MAENNEL DANIELA DR ,  FRANK REINER DR ,  STIEHNER RAINER DR

    IPC: A61K38/00 ,  C07K14/525

    Abstract: Peptides of formula X-Leu-A-B-Asn- E-Leu-F-K-Pro-L-Y (I), derived from tumour necrosis factor (TNF), and their salts with physiologically tolerable acids are new: (where A = Arg, Glu, Thr, Lys or Ser; B = Asp or Asn; E = Gln or Ser; F = Val, Leu or NH-CHT-CO; T = HS(CH2)b, NH2(CH2)b or HOOC(CH2)b; b = 1-6; K = Val or Ile; L = Ser, Ala or Thr; X = G, GNH-CHM-CO or GNH-CHM-COW-; Y = Z, NH-CHQ-COZ, -V-NH-CHQ-COZ; NH-CHQ-CO-V-Z or V-NH-CHQ-CO-V-Z; G = H or amino-protecting gp.; Z = OH, NH2 or carboxy-protecting gp.; or G and Z are together a covalent bond or CO-(CH2)a-NH; a = 1-12; U, V and W = peptide chain with 1-4 naturally occurring amino acids; M and Q = H, CHMe2, CHMe-Et, phenyl, CHOH-Me, (3-indolyl)methyl, (imidazolyl-4-yl)methyl or (CH2)bT; b = 1-6; T = H, OH, MeO, MeS, Me2CH, phenyl (opt. 4-OH substd.), HS, NH2, COOH, CONH2 or guanidino; or M and Q or M and T are together a (CH2)c-S-S-(CH2)d-, (CH2)e-CONH-(CH2)f or (CH2)e-NHCO(CH2)gNH bridge; c and d = 1-4; e and f = 1-6; g = 1-12). (I) are obtd. by standard (chemical or enzymatic) peptide synthesis, initially as linear peptides, opt. followed by appropriate cyclisation reaction under very dilute conditions. USE/ADVANTAGE - Some (I) are TNF agonists, others are TNF antagonists (these have high affinity for cellular receptors but no activity). They are used for treating neoplastic and autoimmune diseases, and for treating or preventing infections, inflammation and transplant rejection. They have significantly lower mol. wt. than TNF.

    7.
    发明专利
    未知

    公开(公告)号：DE4131029A1

    公开(公告)日：1993-07-29

    申请号：DE4131029

    申请日：1991-09-18

    Applicant: BASF AG

    Inventor： BRATZ MATTHIAS DR ,  KOBER REINER DR ,  SEELE RAINER DR ,  SAUPE THOMAS DR ,  WALKER NIGEL DR ,  LANDES ANDREAS DR ,  WALTER HELMUT DR ,  MEYER NORBERT DR

    IPC: A01N25/32 ,  C07D471/04

    Abstract: Herbicidal agents comprising at least one substituted pyrido[2,3-d]pyrimidine I in which R and R represent hydrogen; optionally substituted alkyl; alkoxy; haloalkoxy; alkylamino; alkenyl; alkynyl; optionally substituted cycloalkyl; optionally substituted aryl or heteroaryl; R represents hydroxyl; optionally substituted amino; halogen; alkylthio; alkoxycarbonyl; or a radical R ; R represents a radical R ; CN; NO2; COOH; CSOH; SO2-R ; C(=X)-R ; C(=Y)-R , or R -C(YR )-ZR ; R represents a radical R ; hydroxyl; optionally substituted amino; halogen; alkylthio; pyrrolidin-1-yl; piperidin-1-yl; morpholin-1-yl; optionally substituted alkylcarbonyloxy; optionally substituted alkylsulphonyloxy; optionally substituted aryloxy, arylamino, benzyloxy, benzylamino, aroyloxy or phenylsulphonyloxy; N(R )-SO2-NR ; N-(R )-CO-R ; N(R )-CS-R ; and the phytophysiologically compatible salts of those compounds I in which at least one of the substituents R to R represents an acidic or basic group, and at least one herbicidal active substance selected from amongst A) the group of the cyclohexenone derivatives II or B) the group of the 2-(4-heteroaryloxy)- or 2-(4-aryloxy)-phenoxy carboxylic acid derivatives III.

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