公开(公告)号：CS238636B2

公开(公告)日：1985-12-16

申请号：CS783982

申请日：1982-04-06

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS J ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MUELLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/66

公开(公告)号：CA1184186A

公开(公告)日：1985-03-19

申请号：CA399115

申请日：1982-03-23

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS D ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS J ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MUELLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/78

Abstract: m-Cyano-1,m-dipheny-aza-alkane derivatives of the formula I I wherein Rl, R2, R3, R4, R5, R6, R7, R8, m and n have the meanings given in the description, and salts thereof with physiologically tolerated acids,are useful in treating cardiovascular disorders,

公开(公告)号：CA1207797A

公开(公告)日：1986-07-15

申请号：CA414272

申请日：1982-10-27

Applicant: BASF AG

Inventor： DENGEL FERDINAND ,  TREIBER HANS J ,  SEITZ WERNER ,  MUELLER CLAUS D

IPC: A61K31/135 ,  A61P9/06 ,  C07C67/00 ,  C07C209/00 ,  C07C209/48 ,  C07C211/27 ,  C07C211/29 ,  C07C213/00 ,  C07C217/54 ,  C07C217/62 ,  C07C87/28 ,  C07C93/14

Abstract: Substituted 1,5-diaminopen-tanes of the formula I where R1 and R2 are each hydrogen or C1-C6-alkyl, R3 is C1-C12-alkyl, R4, R5, R6, R7, R8 and R9 are each hydrogen, halogen, C1-C4-alkyl, C1-C4-alkoxy or trifluoromethyl and R10 is hydrogen or methyl, and their salts with physiologically tolerated acids, their preparation and drugs containing these compounds. The substances can be used for the treatment of cardiac arrhythmias.

公开(公告)号：CS238634B2

公开(公告)日：1985-12-16

申请号：CS783782

申请日：1982-04-06

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS D ,  FRIEDRICH LUDWIG ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS J ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MUELLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/66

公开(公告)号：CA1226291A

公开(公告)日：1987-09-01

申请号：CA441471

申请日：1983-11-18

Applicant: BASF AG

Inventor： TREIBER HANS J ,  HOFMANN HANS P ,  KREISKOTT HORST ,  TESCHENDORF HANS-JUERGEN ,  TRAUT MARTIN

IPC: A61K31/13 ,  A61K31/135 ,  A61K31/215 ,  A61K31/265 ,  A61P25/24 ,  A61P25/26 ,  C07C47/00 ,  C07C67/00 ,  C07C213/00 ,  C07C217/30 ,  C07C217/48 ,  C07C219/22 ,  C07C239/00 ,  C07C271/10 ,  C07C313/00 ,  C07C319/20 ,  C07C323/12 ,  C07C323/25 ,  C07D295/08 ,  C07D295/084 ,  C07D295/10 ,  C07D295/104 ,  C07C91/16 ,  C07C149/42 ,  C07D295/04

Abstract: Phenylpropanolamines of the formula I I where R1 is hydrogen or halogen, R2 is hydrogen, a saturated or unsaturated hydrocarbon radical of not more than 15 carbon atoms or phenyl, R3 is hydrogen, a saturated or unsaturated hydrocarbon radical of not more than 3 carbon atoms, C1-C4-acyl, benzoyl, C2-C4-carbalkoxy or a carboxamido group -CO-NHR6, where R6 is C1-C4-alkyl, R4 is hydrogen or halogen, R5 is dimethylamino, piperidino or pyrrolidino and X is oxygen or sulfur, their salts with physiologically tolerated acids and their preparation are described. These compounds are useful for treating psychological illnesses, especially depression.

公开(公告)号：CS238635B2

公开(公告)日：1985-12-16

申请号：CS783882

申请日：1982-04-06

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS D ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS J ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MUELLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/66

公开(公告)号：CS215038B2

公开(公告)日：1982-06-25

申请号：CS21580

申请日：1980-01-09

Applicant: BASF AG

Inventor： TREIBER HANS J ,  LENKE DIETER ,  WORSTMANN WOLFGANG

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/10

Abstract: Novel hexahydro-1,4-oxazepines of the general formula I I where R1 is hydrogen, or alkyl or acyl each of 1 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and R3 and R4 are identical or different and each is hydrogen or methyl, and their salts with physiologically acceptable acids, processes for their preparation, drugs which contain these compounds, and their use in therapy. The compounds may be used for the pharmacotherapy of pain of various geneses.

公开(公告)号：CS208458B2

公开(公告)日：1981-09-15

申请号：CS720879

申请日：1979-10-24

Applicant: BASF AG

Inventor： TREIBER HANS J ,  LENKE DIETER ,  WORSTMANN WOLFGANG

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/00 ,  C07D267/12 ,  C07D267/14

Abstract: PCT No. PCT/EP79/00080 Sec. 371 Date Jun. 26, 1980 Sec. 102(e) Date Jun. 16, 1980 PCT Filed Oct. 22, 1979 PCT Pub. No. WO80/00838 PCT Pub. Date May 1, 1980. The invention relates to novel 1,4-cycloalkano-oxazepines of the general formula where R1 is hydrogen, hydroxyl or alkoxy or acyloxy of 1 to 4 carbon atoms, R2 is a hydrocarbon radical of 1 to 3 carbon atoms, n is 1, 2 or 3 and x is 0 or 1, and of its salts with physiologically acceptable acids; processes for their preparation, and their use in therapy. The novel substances are suitable for the pharmacotherapy of pains of various origins.

公开(公告)号：DD148633A5

公开(公告)日：1981-06-03

申请号：DD21839480

申请日：1980-01-10

Applicant: BASF AG

Inventor： TREIBER HANS J ,  LENKE DIETER ,  WORSTMANN WOLFGANG

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/10

Abstract: Novel hexahydro-1,4-oxazepines of the general formula I I where R1 is hydrogen, or alkyl or acyl each of 1 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and R3 and R4 are identical or different and each is hydrogen or methyl, and their salts with physiologically acceptable acids, processes for their preparation, drugs which contain these compounds, and their use in therapy. The compounds may be used for the pharmacotherapy of pain of various geneses.

公开(公告)号：CA1331992C

公开(公告)日：1994-09-13

申请号：CA527820

申请日：1987-01-21

Applicant: BASF AG

Inventor： UNGER LILIANE ,  RASCHACK MANFRED ,  BALDINGER VERENA ,  DENGEL FERDINAND ,  EHRMANN OSKAR ,  TREIBER HANS J ,  SEITZ WERNER

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61P7/02 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/43 ,  C07C255/53 ,  C07C255/58 ,  C07D317/58 ,  C07D319/08 ,  C07D319/18 ,  C07D321/12 ,  C07D325/00 ,  C07D317/60

Abstract: Compounds of the formula I. where R1 to R7, m, n and p have the meanings stated in the description, and certain derivatives which are p-sub-stituted in the left-hand phenyl ring, are useful for the treatment of disorders.