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    METHOD FOR THE PRODUCTION OF HALOGEN-SUBSTITUTED 2-(AMINOMETHYLIDENE)-3- OXOBUTYRIC ACID ESTERS
    1.
    发明申请
    METHOD FOR THE PRODUCTION OF HALOGEN-SUBSTITUTED 2-(AMINOMETHYLIDENE)-3- OXOBUTYRIC ACID ESTERS 审中-公开
    用于生产方法卤素取代的2-（氨基亚甲基）-3-氧代丁酸

    公开(公告)号：WO2009133179A3

    公开(公告)日：2010-02-25

    申请号：PCT/EP2009055285

    申请日：2009-04-30

    Applicant: BASF SE ,  ZIERKE THOMAS ,  MAYWALD VOLKER ,  RACK MICHAEL ,  SMIDT SEBASTIAN PEER ,  KEIL MICHAEL ,  WOLF BERND ,  KORADIN CHRISTOPHER

    Inventor： ZIERKE THOMAS ,  MAYWALD VOLKER ,  RACK MICHAEL ,  SMIDT SEBASTIAN PEER ,  KEIL MICHAEL ,  WOLF BERND ,  KORADIN CHRISTOPHER

    IPC: C07D231/14 ,  C07D295/145

    CPC classification number: C07D295/145 ,  C07D231/14

    Abstract: The present invention relates to a method for producing 2- (aminomethylidene)-4,4dihalo-3-oxobutyric acid esters of the formula (I), where R1, R2, R3 are C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C10-cycloalkyl or benzyl and/or R2 together with R3 and the nitrogen atom, to which both radicals are bound, are a heterocyclic radical, wherein a corresponding 3-aminoacrylic acid ester is reacted with a halogen-substituted acetyl fluoride in the presence of at least one alkali or earth alkali metal fluoride. The invention also relates to the further reaction of halogen-substituted 2-(aminomethylidene)-3-oxobutyric acid esters of the formula (1) into halomethyl-substituted pyrazole-4-ylcarboxylic acids and the esters thereof.

    Abstract translation: 本发明涉及2-（氨基 - 亚甲基）的制备方法中，式-4,4-二卤代-3-氧代丁酸酯（I）其中R1，R2，R3是C1-C6烷基，C1-C6卤代烷基 ，C2-C6链烯基，C3-C10环烷基或与R 3苄基和/或R 2在一起并到两个基团连接的氮原子代表的杂环基团，其中一个相应的3-氨基丙烯酸酯是具有 卤乙酰氟取代反应是在至少一种碱金属或碱土金属氟化物的存在; 和卤素 - 取代的2-（氨基亚甲基）-3-氧代丁酸的式（I）的酯的进一步反应卤代甲基取代的吡唑-4-基甲酸和它们的酯。

    METHOD FOR PREPARING 1,3,4-SUBSTITUTED PYRAZOL COMPOUNDS
    2.
    发明申请
    METHOD FOR PREPARING 1,3,4-SUBSTITUTED PYRAZOL COMPOUNDS 审中-公开
    用于生产取代1,3,4-吡唑

    公开(公告)号：WO2009135808A2

    公开(公告)日：2009-11-12

    申请号：PCT/EP2009055328

    申请日：2009-05-04

    Applicant: BASF SE ,  WOLF BERND ,  MAYWALD VOLKER ,  KEIL MICHAEL ,  KORADIN CHRISTOPHER ,  RACK MICHAEL ,  ZIERKE THOMAS ,  SUKOPP MARTIN

    Inventor： WOLF BERND ,  MAYWALD VOLKER ,  KEIL MICHAEL ,  KORADIN CHRISTOPHER ,  RACK MICHAEL ,  ZIERKE THOMAS ,  SUKOPP MARTIN

    IPC: C07D231/14

    CPC classification number: C07D409/12 ,  C07C251/76 ,  C07C251/84 ,  C07C251/86 ,  C07D231/14

    Abstract: The present invention relates to a method for preparing 1,3-substituted pyrazol compounds of formula (I), where X stands for a group CX1X2X3, with X1, X2 and X3 being hydrogen, fluorine or chlorine, independently of one another, R1 being an C1-C4 alkyl or cyclopropyl, and R2 being hydrogen, CN or a group CO2R2a, where R2a stands for C1-C6 alkyl in particular, comprising the following steps: i) reacting a compound of formula II with a hydrazone of formula (III), wherein in formula (II) the variables X and R2 have the same meaning as indicated for formula (I), Y stands for oxygen, a group NRy1 or a group [NRy2Ry3]+Z- , R3 stands for OR3a or a group NR3bR3c, and wherein in formula (III) the variable R1 has the same meaning as indicated for formula (I), R4 and R5 stand for hydrogen, C1-C6 alkyl, alternatively substituted phenyl, independent of one another, wherein at least one of the radicals R4 or R5 is different from hydrogen and where R4 and R5 can also stand for a 5 to 10-membered saturated carbocycle together with the carbon atom connected thereto; treatment of the reaction product obtained thereby with an acid in the presence of water.

    Abstract translation: 本发明涉及一种方法，用于制备1,3-取代的式（I），其中X是特别的一组CX1X2X3，其中X1，X2和X3独立地为特别是氢，氟或氯的吡唑化合物中，R1是C1 〜C 4烷基或环丙基，和R 2是氢，CN或基团CO2R2a，其中R 2a是特别C1-C6烷基，所述方法包括以下步骤：i）将式II的化合物与下式的腙反应 （III）其中在式（II）中，变量，X和R 2具有对式（I）所给出的含义，Y是氧，一组或一组NRy1 [NRy2Ry3] + Z-，R 3表示OR3a或一组NR3bR3c ，并且其中，在式（III）中，变量R1具有式（I）中给出的含义，R4和R5独立地是氢，C1-C6烷基，其任选被取代的苯基，其中至少一个基团 ëR4或R5是不同于氢，并且其中可以与它们所连接为一个5至10元饱和碳环，R4和R5的碳原子一起; 在水存在下用酸处理所得到的反应产物。

    METHOD FOR MANUFACTURING ARYL CARBOXAMIDES.
    9.
    发明专利
    METHOD FOR MANUFACTURING ARYL CARBOXAMIDES. 未知

    公开(公告)号：MX317270B

    公开(公告)日：2014-01-20

    申请号：MX2010011276

    申请日：2009-05-06

    Applicant: BASF SE

    Inventor： KEIL MICHAEL ,  WOLF BERND ,  ZIERKE THOMAS ,  RACK MICHAEL ,  MAYWALD VOLKER ,  KORADIN CHRISTOPHER ,  SMIDT SEBASTIAN PEER ,  REICHERT WOLFGANG

    Abstract: A process for preparing arylcarboxamides of the formula (I) where Ar=a mono- to trisubstituted phenyl, pyridyl or pyrazolyl ring, where the substituents are selected from halogen, C1-C4-alkyl and C1-C4-haloalkyl; M=thienyl or phenyl, which may bear a halogen substituent; Q=direct bond, cyclopropylene, fused bicyclo[2.2.1]heptane or bicyclo[2.2.1]heptene ring; R1=hydrogen, halogen, C1-C6-alkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, mono- to trisubstituted phenyl, where the substituents are selected from halogen and trifluoromethylthio, or cyclopropyl; by reacting an acid chloride of the formula (II) with an arylamine (III) in a suitable nonaqueous solvent, wherein, in the absence of an auxiliary base, a) the acid chloride (II) is initially charged, b) a pressure of from 0 to 700 mbar is established, c) the arylamine (III) is metered in an approximately stoichiometric amount and d) the product of value is isolated.

    Método para la preparación de ésteres halosustituidos de ácido 2-(aminometiliden)-3-oxobutírico
    10.
    发明专利
    Método para la preparación de ésteres halosustituidos de ácido 2-(aminometiliden)-3-oxobutírico 未知

    公开(公告)号：ES2386940T3

    公开(公告)日：2012-09-06

    申请号：ES09738223

    申请日：2009-04-30

    Applicant: BASF SE

    Inventor： ZIERKE THOMAS ,  MAYWALD VOLKER ,  RACK MICHAEL ,  SMIDT SEBASTIAN PEER ,  KEIL MICHAEL ,  WOLF BERND ,  KORADIN CHRISTOPHER

    IPC: C07D231/14 ,  C07D295/145

    Abstract: Método para la preparación de compuestos de la fórmula (I), **Fórmula**dondeR1 representa alquilo de C1-C6, haloalquilo de C1-C6, alquenilo de C2-C6, cicloalquilo de C3-C10 o bencilo, en cuyocaso ambos residuos mencionados de último están sin sustituir o tienen 1, 2 o 3 sustituyentes seleccionadosindependientemente entre sí de halógeno, CN, nitro, alquilo de C1-C4, haloalquilo de C1-C4, alcoxi de C1-C4 yhaloalcoxi de C1-C4;R2 y R3, independientemente entre sí, representan alquilo de C1-C6, haloalquilo de C1-C6, alquenilo de C2-C6,cicloalquilo de C3-C10 o bencilo, en cuyo caso los dos residuos mencionados de último están sin sustituir o tienen o1, 2 o 3 sustituyentes seleccionados independientemente entre sí de entre halógeno, CN, nitro, alquilo de C1-C4,haloalquilo de C1-C4, alcoxi de C1-C4 y haloalcoxi de C1-C4; oR2 conjuntamente con R3 y el átomo de nitrógeno al cual ambos residuos están enlazados representan un residuoheterocíclico de 5 a 10 miembros opcionalmente sustituidos, el cual puede comprender, además del átomo denitrógeno, 1, 2 o 3 heteroátomos más seleccionados entre O, N y S en calidad de miembros de anillo;R4 representa hidrógeno, flúor o cloro; yX1 y X2, independientemente entre sí, representan flúor o cloro;En el cual se hace reaccionar un compuesto de la fórmula (II),donde R1, R2 y R3 tienen uno de los significados dados previamente; con un compuesto de la fórmula X1X2R420 CC(>=O)-F en presencia de al menos un fluoruro de metal alcalino o de metal alcalino térreo.

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