公开(公告)号：AU2014206958B2

公开(公告)日：2017-08-10

申请号：AU2014206958

申请日：2014-01-15

Applicant: BASF SE

Inventor： BONNEKESSEL MELANIE ,  REICHERT WOLFGANG ,  HOOCK RALF ,  KAEDING THOMAS ,  KORADIN CHRISTOPHER ,  PLETSCH ANDREAS ,  EHRESMANN MANFRED ,  SCHRODER HARTWIG

IPC: C07D493/04 ,  A01N43/90

Abstract: The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11-trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor;and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i).

公开(公告)号：PL2285779T3

公开(公告)日：2013-08-30

申请号：PL09742078

申请日：2009-05-06

Applicant: BASF SE

Inventor： REICHERT WOLFGANG ,  KORADIN CHRISTOPHER ,  SMIDT SEBASTIAN PEER ,  MAYWALD VOLKER ,  WOLF BERND ,  RACK MICHAEL ,  ZIERKE THOMAS ,  KEIL MICHAEL

IPC: C07D213/82 ,  C07C231/02 ,  C07C233/57 ,  C07C233/64 ,  C07D231/14 ,  C07D231/16

公开(公告)号：ZA201008742B

公开(公告)日：2012-02-29

申请号：ZA201008742

申请日：2010-12-06

Applicant: BASF SE

Inventor： REICHERT WOLFGANG ,  KORADIN CHRISTOPHER ,  SMIDT SEBASTIAN PEER ,  MAYWALD VOLKER ,  WOLF BERND ,  RACK MICHAEL ,  ZIERKE THOMAS ,  KEIL MICHAEL

IPC: C07D20060101 ,  C07C20060101

Abstract: A process for preparing arylcarboxamides of the formula (I) where Ar=a mono- to trisubstituted phenyl, pyridyl or pyrazolyl ring, where the substituents are selected from halogen, C1-C4-alkyl and C1-C4-haloalkyl; M=thienyl or phenyl, which may bear a halogen substituent; Q=direct bond, cyclopropylene, fused bicyclo[2.2.1]heptane or bicyclo[2.2.1]heptene ring; R1=hydrogen, halogen, C1-C6-alkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, mono- to trisubstituted phenyl, where the substituents are selected from halogen and trifluoromethylthio, or cyclopropyl; by reacting an acid chloride of the formula (II) with an arylamine (III) in a suitable nonaqueous solvent, wherein, in the absence of an auxiliary base, a) the acid chloride (II) is initially charged, b) a pressure of from 0 to 700 mbar is established, c) the arylamine (III) is metered in an approximately stoichiometric amount and d) the product of value is isolated.

公开(公告)号：ES2742301T3

公开(公告)日：2020-02-13

申请号：ES14700640

申请日：2014-01-15

Applicant: BASF SE

Inventor： BONNEKESSEL MELANIE ,  REICHERT WOLFGANG ,  HOOCK RALF ,  KAEDING THOMAS ,  KORADIN CHRISTOPHER ,  PLETSCH ANDREAS ,  EHRESMANN MANFRED ,  SCHRÖDER HARTWIG

IPC: C07D493/04 ,  A01N43/90

Abstract: Método para preparar el compuesto de piripiropeno de fórmula I,**Fórmula** comprendiendo el método las siguientes etapas: i) someter un compuesto de piripiropeno de fórmula II a una hidrólisis alcalina para producir un compuesto de piripiropeno de fórmula III,**Fórmula** ii) hacer reaccionar el compuesto de piripiropeno de fórmula III obtenido en la etapa i) con cloruro de ciclopropanocarbonilo para producir un producto sin procesar que contiene el compuesto de piripiropeno de fórmula I; iii) someter el producto sin procesar de la etapa ii) a cristalización para producir un compuesto de piripiropeno cristalino de fórmula I y unas aguas madre; y iv) recircular las aguas madre o una fracción que contiene compuesto de piripiropeno de las mismas a la hidrólisis alcalina de la etapa i).

公开(公告)号：MX317270B

公开(公告)日：2014-01-20

申请号：MX2010011276

申请日：2009-05-06

Applicant: BASF SE

Inventor： KEIL MICHAEL ,  WOLF BERND ,  ZIERKE THOMAS ,  RACK MICHAEL ,  MAYWALD VOLKER ,  KORADIN CHRISTOPHER ,  SMIDT SEBASTIAN PEER ,  REICHERT WOLFGANG

Abstract: A process for preparing arylcarboxamides of the formula (I) where Ar=a mono- to trisubstituted phenyl, pyridyl or pyrazolyl ring, where the substituents are selected from halogen, C1-C4-alkyl and C1-C4-haloalkyl; M=thienyl or phenyl, which may bear a halogen substituent; Q=direct bond, cyclopropylene, fused bicyclo[2.2.1]heptane or bicyclo[2.2.1]heptene ring; R1=hydrogen, halogen, C1-C6-alkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, mono- to trisubstituted phenyl, where the substituents are selected from halogen and trifluoromethylthio, or cyclopropyl; by reacting an acid chloride of the formula (II) with an arylamine (III) in a suitable nonaqueous solvent, wherein, in the absence of an auxiliary base, a) the acid chloride (II) is initially charged, b) a pressure of from 0 to 700 mbar is established, c) the arylamine (III) is metered in an approximately stoichiometric amount and d) the product of value is isolated.

公开(公告)号：MX2010011276A

公开(公告)日：2010-11-09

申请号：MX2010011276

申请日：2009-05-06

Applicant: BASF SE

Inventor： KEIL MICHAEL ,  WOLF BERND ,  ZIERKE THOMAS ,  RACK MICHAEL ,  MAYWALD VOLKER ,  KORADIN CHRISTOPHER ,  SMIDT SEBASTIAN PEER ,  REICHERT WOLFGANG

IPC: C07D213/82 ,  C07C231/02 ,  C07C233/57 ,  C07C233/64 ,  C07D231/14 ,  C07D231/16

Abstract: Procedimiento para la obtención de arilcarboxamidas de la fórmula (I) (ver formula (I)) en la que Ar = es un anillo fenilo, piridilo o pirazolilo mono a trisustituido, seleccionando los sustituyentes de halógeno, C1-C4-alquilo y C1-C4-halógenoalquilo; M = es tienilo o fenilo, que puede llevar un sustituyente halógeno; Q = es un enlace directo, ciclopropileno, un anillo biciclo(2.2.1]heptano o biciclo[2.2.1]hepteno anelado; R1 = es hidrógeno, halógeno, C1-C6-alquilo, C1-C4-alcoxi, C1-C4-halógenoalcoxi, fenilo mono a trisustituido, seleccionando los sustituyentes de halógeno y trifluorometiltio, o ciclopropilo; transformando un cloruro de ácido de la fórmula (II) (ver fórmula (II) con una arilamina (III) (ver fórmulas (III)) en un solvente no soluble en agua apropiado, en cuyo procedimiento a) se presenta el cloruro de ácido (II) como carga inicial en presencia de una base auxiliar, b) se regula una presión de 0 hasta 700 mbar, c) se dosifica la arilamina (III) en cantidad aproximadamente estequiométrica y d) se aísla el producto de valor.

公开(公告)号：EA018518B1

公开(公告)日：2013-08-30

申请号：EA201001730

申请日：2009-05-06

Applicant: BASF SE

Inventor： REICHERT WOLFGANG ,  KORADIN CHRISTOPHER ,  SMIDT SEBASTIAN PEER ,  MAYWALD VOLKER ,  WOLF BERND ,  RACK MICHAEL ,  ZIERKE THOMAS ,  KEIL MICHAEL

IPC: C07D213/82 ,  C07C231/02 ,  C07C233/57 ,  C07C233/64 ,  C07D231/14 ,  C07D231/16

Abstract: Способполученияарилкарбоксамидовформулы (I)причем Ar представляетсобойфенильное, пиридильноеилипиразолильноекольцо, замещенноеотодногодотрехраззаместителями, независимовыбраннымиизгалогена, C-C-алкилаи С-С-галогеналкила; Мпредставляетсобойтиенилилифенил, возможнозамещенныйгалогеном; Q представляетсобойнепосредственносвязь, циклопропилен, аннелированноебицикло[2.2.1]гептановоеилибицикло[2.2.1]гептеновоекольцо; Rпредставляетсобойводород, галоген, C-C-алкил, С-С-алкокси, C-C-галогеналкокси, фенил, замещенныйотодногодотрехраззаместителями, независимовыбраннымиизгалогенаи трифторметилтио, илициклопропила; путемвзаимодействияхлорангидридакислотыформулы (II)сариламином (III)вприемлемомневодномрастворителе, причемприотсутствиивспомогательногооснования a) предоставляютхлорангидридкислоты (II), b) устанавливаютдавлениеот 200 до 700 мбар, c) добавляютариламин (III) впримерностехиометрическомколичествеи d) выделяютарилкарбоксамидформулы (I).

公开(公告)号：CA2721695A1

公开(公告)日：2009-11-12

申请号：CA2721695

申请日：2009-05-06

Applicant: BASF SE

Inventor： REICHERT WOLFGANG ,  KORADIN CHRISTOPHER ,  SMIDT SEBASTIAN PEER ,  MAYWALD VOLKER ,  WOLF BERND ,  RACK MICHAEL ,  ZIERKE THOMAS ,  KEIL MICHAEL

IPC: C07D213/82 ,  C07C231/02 ,  C07C233/57 ,  C07C233/64 ,  C07D231/14 ,  C07D231/16

Abstract: Method for manufacturing aryl carboxamides of the formula (I), with Ar = singly to triply substituted phenyl , pyridyl or pyrazolyl rings, wherein the substituents are selected from halogen, C1-C4 alkyl and C1-C4 halogen alkyl; M = thienyl or phenyl, which can contain a halogen substituent; Q = direct bond, cyclopropylene, annulated bicyclo[2.2.1 ]heptane or bicyclo[2.2.1 ]heptene ring; R1 = hydrogen, halogen, C1-C6 alkyl, C1-C4 alkoxy, Ci-C4 halogen alkoxy, singly to triply substituted phenyl, wherein the substituents are selected from halogen and trifluoromethylthio, or cyclopropyl; through reaction of an acid chloride of the formula (II) with an aryl amine (III) in a suitable non-aqueous solvent, wherein in the absence of an auxiliary base a) the acid chloride (II) is added, b) a pressure of 0 to 700 mbar is established, c) the aryl amine (III) is added in approximately stoichiometric amounts and d) the valuable product is isolated.

公开(公告)号：DK2945949T3

公开(公告)日：2019-08-05

申请号：DK14700640

申请日：2014-01-15

Applicant: BASF SE

Inventor： HOOCK RALF ,  KORADIN CHRISTOPHER ,  PLETSCH ANDREAS ,  EHRESMANN MANFRED ,  BONNEKESSEL MELANIE ,  KAEDING THOMAS ,  SCHRÖDER HARTWIG ,  REICHERT WOLFGANG

IPC: C07D493/04 ,  A01N43/90

公开(公告)号：CA2721695C

公开(公告)日：2016-04-12

申请号：CA2721695

申请日：2009-05-06

Applicant: BASF SE

Inventor： REICHERT WOLFGANG ,  KORADIN CHRISTOPHER ,  SMIDT SEBASTIAN PEER ,  MAYWALD VOLKER ,  WOLF BERND ,  RACK MICHAEL ,  ZIERKE THOMAS ,  KEIL MICHAEL

IPC: C07D213/82 ,  C07C231/02 ,  C07C233/57 ,  C07C233/64 ,  C07D231/14 ,  C07D231/16

Abstract: Method for manufacturing aryl carboxamides of the formula (I), with Ar = singly to triply substituted phenyl , pyridyl or pyrazolyl rings, wherein the substituents are selected from halogen, C1-C4 alkyl and C1-C4 halogen alkyl; M = thienyl or phenyl, which can contain a halogen substituent; Q = direct bond, cyclopropylene, annulated bicyclo [2.2.1]heptane or bicyclo[2.2.1]heptene ring; R1 = hydrogen, halogen, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 halogen alkoxy, singly to triply substituted phenyl, wherein the substituents are selected from halogen and trifluoromethylthio, or cyclopropyl; through reaction of an acid chloride of the formula (II) with an aryl amine (III) in a suitable non-aqueous solvent, wherein in the absence of an auxiliary base a) the acid chloride (II) is added, b) a pressure of 0 to 700 mbar is established, c) the aryl amine (III) is added in approximately stoichiometric amounts and d) the valuable product is isolated.