公开(公告)号：WO1996036296A1

公开(公告)日：1996-11-21

申请号：PCT/US1996006826

申请日：1996-05-13

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  PAULEY, Robin, G. ,  McLARTY, Donna, L. ,  KHARE, Atul, R. ,  STERNBERG, Shmuel ,  BOGGS, Daniel, R. ,  NEUENFELDT, Steven ,  JONES, Mark ,  BRAUKER, James, H. ,  MARTINSON, Laura, A.

IPC: A61F02/02

CPC classification number: A61K9/0024 ,  A61F2/022 ,  A61L27/38

Abstract: A permeable structure (16) forms a chamber (12) to hold living cells (14). The structure includes a first permeable region (18) surrounding at least a portion of the chamber (12) having a confirmation that, when implanted is host tissue, substantially blocks penetration of host cells into the chamber (12) while permitting solute transport. The structure (16) also includes a second permeable region (20) overlaying the first permeable region (18) having a confirmation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region (22) is located between the first (18) and second (20) permeable regions. The third region (22) comprises a solution of polymer material formed in place between the first (18) and second (20) permeable regions. The third permeable region (22) bonds the first (18) and second (20) permeable regions together. The third permeable region (22) also has a confirmation that, when implanted in host tissue, permits solute transport between the first (18) and second (20) permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first (18) and second (20) regions. The third, formed-in-place region (22) can also have a confirmation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane (22) is sufficient high that it does not adversely effect the permability value desired for the overall multiple layer structure (16).

Abstract translation: 可渗透结构（16）形成容纳活细胞（14）的腔室（12）。 该结构包括围绕腔室（12）的至少一部分的第一可渗透区域（18），其确认当植入的是宿主组织时，基本上阻止宿主细胞渗入腔室（12），同时允许溶质运输。 结构（16）还包括覆盖第一可渗透区域（18）的第二可渗透区域（20），其确认当植入宿主组织时，与允许溶质运输的宿主组织形成可渗透界面。 第三可渗透区域（22）位于第一（18）和第二（20）可渗透区域之间。 第三区域（22）包括在第一（18）和第二（20）可渗透区域之间形成的聚合物材料溶液。 第三可渗透区域（22）将第一（18）和第二（20）可渗透区域结合在一起。 第三渗透区域（22）还确认，当植入到宿主组织中时，允许第一（18）和第二（20）可渗透区域之间的溶质传输在一起，提供坚固的层压结构，其抵抗植入期间的分层，由 细胞浸润到第一（18）和第二（20）区域之间的不连续空间。 第三个就地区域（22）也可以具有提供免疫隔离效果的确认。 此外，第三就地形成膜（22）的渗透性足够高，使得其不会对整个多层结构（16）所期望的渗透性值产生不利影响。

公开(公告)号：EP1353793A1

公开(公告)日：2003-10-22

申请号：EP02708965.5

申请日：2002-01-04

Applicant: Baxter International Inc.

Inventor： LING, Michael T., K. ,  HURST, William, S. ,  WOO, Lecon ,  BINDOKAS, Algirdas ,  RYAN, Patrick, T. ,  EDWARDS, Scott, D. ,  BLOM, Henk, P. ,  KHARE, Atul, R.

IPC: B32B1/08 ,  B29C65/04 ,  A61L29/12 ,  C08L23/10

CPC classification number: C08L23/12 ,  A61L29/126 ,  B29C65/04 ,  B29C66/1122 ,  B29C66/53262 ,  B29C66/71 ,  B29C66/7234 ,  B29C2035/0861 ,  B32B1/08 ,  B32B27/08 ,  B32B27/32 ,  C08L23/0815 ,  C08L23/0869 ,  C08L23/142 ,  C08L51/00 ,  C08L53/02 ,  C08L75/04 ,  C08L77/00 ,  C08L101/00 ,  C08L2314/06 ,  Y10T428/1352 ,  Y10T428/1386 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/31746 ,  Y10T428/31913 ,  Y10T428/31924 ,  Y10T428/31931 ,  C08L2666/24 ,  C08L2666/04 ,  B29C65/00 ,  B29K2079/08 ,  B29K2077/00 ,  B29K2075/02 ,  B29K2075/00 ,  B29K2067/00 ,  B29K2033/12 ,  B29K2033/08 ,  B29K2023/18 ,  B29K2023/14 ,  B29K2023/12 ,  B29K2023/086 ,  B29K2023/083 ,  B29K2023/08 ,  B29K2021/003 ,  B29K2009/00

Abstract: The present invention provides a flowable material container closure assembly having a port tube and a membrane tube. The port tube has a first layer and a second layer, the first layer is a polymer blend and the second layer is disposed coaxially within the first layer; and the membrane tube is disposed coaxially within the port tube, the membrane tube has an outer layer, a core layer and an inner layer.