公开(公告)号：WO2005026693A3

公开(公告)日：2006-06-29

申请号：PCT/US2004029633

申请日：2004-09-10

Applicant: BIO RAD LABORATORIES ,  PROVOST ROGER ,  STRONG WILLIAM

Inventor： PROVOST ROGER ,  STRONG WILLIAM

IPC: G01N27/26 ,  G01N27/447 ,  G01N27/453

CPC classification number: G01N27/44717 ,  G01N27/44704

Abstract: Gel plugs that can be stored in a sealed condition and delivered individually to an electrophoresis gel as standards for electrophoretic separations are retained in a cartridge that is cleanly breakable into individual sections, each section retaining a gel plug of predefined dimensions with standard solute mixtures embedded in the plug. The separation of any single section from the cartridge exposes opposing edges of the gel plug which permits the user to insert an implement into the section interior and to urge the plug out of the section and into a well of an electrophoresis gel. All manipulations are performed without any need for contact between the user and the gel.

Abstract translation: 可以以密封状态存储并单独输送到电泳凝胶作为电泳分离标准的凝胶塞被保留在可干燥地破碎成单个部分的筒中，每个部分保留预定义尺寸的凝胶塞，其中嵌入标准溶质混合物 插头 任何单个部分与药筒的分离暴露出凝胶塞的相对边缘，其允许使用者将器具插入部分内部并将塞子推出该部分并进入电泳凝胶的孔中。 执行所有操作，而不需要用户和凝胶之间的接触。

公开(公告)号：CA2782346C

公开(公告)日：2016-04-26

申请号：CA2782346

申请日：2010-12-09

Applicant: BIO RAD LABORATORIES

Inventor： LATHAM MATTHEW ,  STRONG WILLIAM ,  CHMIEL NIKOLAS ,  XU JEFF ,  IOVANNI ROBERT

IPC: G01N27/447

Abstract: Electrotransfer is performed in an instrument that receives electroblotting cassettes and that contains an integrated power supply, controls, and a display that allows the user to monitor and control each of a plurality of cassettes individually through electrical contacts within the housing that mate with corresponding electrical contacts on the cassettes.

公开(公告)号：SG181105A1

公开(公告)日：2012-07-30

申请号：SG2012039251

申请日：2010-12-09

Applicant: BIO RAD LABORATORIES

Inventor： LATHAM MATTHEW ,  STRONG WILLIAM ,  CHMIEL NIKOLAS ,  XU JEFF ,  IOVANNI ROBERT

Abstract: Electrotransfer is performed in an instrument that receives electroblotting cassettes and that contains an integrated power supply, controls, and a display that allows the user to monitor and control each of a plurality of cassettes individually through electrical contacts within the housing that mate with corresponding electrical contacts on the cassettes.

公开(公告)号：CA2782346A1

公开(公告)日：2011-06-16

申请号：CA2782346

申请日：2010-12-09

Applicant: BIO RAD LABORATORIES

Inventor： LATHAM MATTHEW ,  STRONG WILLIAM ,  CHMIEL NIKOLAS ,  XU JEFF ,  IOVANNI ROBERT

IPC: A61N1/30

Abstract: Electrotransfer is performed in an instrument that receives electroblotting cassettes and that contains an integrated power supply, controls, and a display that allows the user to monitor and control each of a plurality of cassettes individually through electrical contacts within the housing that mate with corresponding electrical contacts on the cassettes.

公开(公告)号：DE602004021398D1

公开(公告)日：2009-07-16

申请号：DE602004021398

申请日：2004-09-10

Applicant: BIO RAD LABORATORIES

Inventor： PROVOST ROGER ,  STRONG WILLIAM

IPC: G01N27/26 ,  G01N27/447 ,  G01N27/453

Abstract: Gel plugs that can be stored in a sealed condition and delivered individually to an electrophoresis gel as standards for electrophoretic separations are retained in a cartridge that is cleanly breakable into individual sections, each section retaining a gel plug of predefined dimensions with standard solute mixtures embedded in the plug. The separation of any single section from the cartridge exposes opposing edges of the gel plug which permits the user to insert an implement into the section interior and to urge the plug out of the section and into a well of an electrophoresis gel. All manipulations are performed without any need for contact between the user and the gel.

公开(公告)号：CA2536601C

公开(公告)日：2009-06-23

申请号：CA2536601

申请日：2004-09-10

Applicant: BIO RAD LABORATORIES

Inventor： STRONG WILLIAM ,  PROVOST ROGER

IPC: G01N27/447 ,  G01N27/453

Abstract: Gel plugs that can be stored in a sealed condition and delivered individuall y to an electrophoresis gel as standards for electrophoretic separations are retained in a cartridge that is cleanly breakable into individual sections, each section retaining a gel plug of predefined dimensions with standard solute mixtures embedded in the plug. The separation of any single section from the cartridge exposes opposing edges of the gel plug which permits the user to insert an implement into the section interior and to urge the plug o ut of the section and into a well of an electrophoresis gel. All manipulations are performed without any need for contact between the user and the gel.

公开(公告)号：CA2536601A1

公开(公告)日：2005-03-24

申请号：CA2536601

申请日：2004-09-10

Applicant: BIO RAD LABORATORIES

Inventor： PROVOST ROGER ,  STRONG WILLIAM

IPC: G01N27/447 ,  G01N27/453

Abstract: Gel plugs that can be stored in a sealed condition and delivered individuall y to an electrophoresis gel as standards for electrophoretic separations are retained in a cartridge that is cleanly breakable into individual sections, each section retaining a gel plug of predefined dimensions with standard solute mixtures embedded in the plug. The separation of any single section from the cartridge exposes opposing edges of the gel plug which permits the user to insert an implement into the section interior and to urge the plug o ut of the section and into a well of an electrophoresis gel. All manipulations are performed without any need for contact between the user and the gel.

公开(公告)号：WO2015084887A3

公开(公告)日：2015-11-12

申请号：PCT/US2014068230

申请日：2014-12-02

Applicant: BIO RAD LABORATORIES

Inventor： STRONG WILLIAM

IPC: G01N27/447

CPC classification number: G01N27/44704

Abstract: Molds for casting and retaining electrophoresis gel strips are provided, along with methods, kits, and systems for performing electrophoresis, electroelution, and/or electroblotting. A mold according to some embodiments includes: an array of elongated lane cavities, each lane cavity having a top end, a bottom end, and two or more sides, the lane cavities oriented parallel to each other; a matrix comprising at least one solid material and disposed along the sides of the lane cavities, the matrix separating the lane cavities from each other and from the space outside the mold; and a plurality of windows, wherein two windows are associated with each lane cavity and are disposed on opposite sides of the lane cavity, each window running lengthwise along the lane cavity and penetrating the matrix, thereby forming a passage from the lane cavity through the matrix to an adjacent lane cavity or the space outside the mold.

Abstract translation: 提供用于铸造和保留电泳胶条的模具，以及用于进行电泳，电洗脱和/或电印迹的方法，试剂盒和系统。 根据一些实施例的模具包括：细长通道腔的阵列，每个通道腔具有顶端，底端和两个或更多个侧面，所述通道腔彼此平行取向; 包括至少一种固体材料并沿着所述通道腔的侧面设置的矩阵，所述基体将所述通道腔彼此分开并且与所述模具外部的空间分离; 以及多个窗口，其中两个窗口与每个通道空腔相关联并且设置在通道腔的相对侧上，每个窗口沿着通道腔沿纵向延伸并穿透基质，从而形成从通道腔通过矩阵的通道 到相邻车道腔或模具外部的空间。

公开(公告)号：WO2014172269A3

公开(公告)日：2015-10-29

申请号：PCT/US2014033978

申请日：2014-04-14

Applicant: BIO RAD LABORATORIES

Inventor： MCKEE CLAYTON T ,  STRONG WILLIAM ,  BHATT NEERAJ

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/6456

Abstract: Systems and methods for simultaneously exciting a fluorescently labeled specimen and capturing fluorescent light emitted therefrom using a smartphone, tablet, or similar mobile computing device, are disclosed herein. The system includes a light-emitting diode ("LED") light source coupled with the smartphone to excite the specimen and an imaging device coupled with the smartphone to capture fluorescent light emitted from the specimen. The system further includes a hood adapted to be coupled with the smartphone that has an excitation filter configured to produce a first wavelength of electromagnetic radiation to strike the specimen when light from the LED light source passes through it and an emission filter configured to receive the light emitted from the specimen and to produce a second wavelength of electromagnetic radiation to be captured by the imaging device.

Abstract translation: 本文公开了同时激发荧光标记的样本并使用智能电话，平板电脑或类似的移动计算设备捕获从其发射的荧光的系统和方法。 该系统包括与智能手机耦合以激发样本的发光二极管（“LED”）光源和与智能手机耦合的成像装置以捕获从样品发射的荧光。 该系统还包括适于与智能电话耦合的罩，其具有激励滤波器，该激励滤波器被配置为产生第一波长的电磁辐射以在来自LED光源的光穿过其时撞击样本;以及发射滤波器，被配置为接收光 从样品发射并产生将被成像装置捕获的第二波长的电磁辐射。

公开(公告)号：EP2877483A4

公开(公告)日：2016-07-06

申请号：EP13823401

申请日：2013-07-25

Applicant: BIO RAD LABORATORIES

Inventor： MCKEE CLAYTON T ,  STRONG WILLIAM

IPC: C07K1/04 ,  C07K1/14 ,  C12M1/00 ,  G01N27/447

CPC classification number: G01N27/44739 ,  G01N27/44747 ,  G01N33/54306 ,  G01N33/54393

Abstract: Molecular species that are immobilized in discrete locations on a planar support such as protein bands on a gel or a blotting membrane or species applied in dots or spots on a membrane are reacted with binding reagents that are applied through a porous hydrophilic transfer sheet placed over the planar support, the sheet having at least one region that is laterally bordered by a barrier with the binding reagent retained within the bordered region. The bordered region is placed directly over an area on the planar support where the molecular species are expected to reside if they are present on the support. The binding reagent is then delivered into the support to contact the species. Targeted delivery of the binding reagent is thus achieved with improved efficiency.