公开(公告)号：WO2011022690A2

公开(公告)日：2011-02-24

申请号：PCT/US2010046220

申请日：2010-08-20

Applicant: CALIFORNIA INST OF TECHN ,  SCHERER AXEL ,  RAJAGOPAL ADITYA ,  KIM SEHEON ,  HOMYK ANDREW P

Inventor： SCHERER AXEL ,  RAJAGOPAL ADITYA ,  KIM SEHEON ,  HOMYK ANDREW P

IPC: H01L31/04

CPC classification number: H02J50/30 ,  A61B5/0017 ,  A61B5/6867 ,  A61B2560/0219 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0283 ,  G01N21/25 ,  H01L31/03529 ,  H01L31/0475 ,  H01L31/054 ,  H02J7/025 ,  H02J17/00 ,  H02J50/80 ,  H02S40/38 ,  H03F3/082 ,  H03F3/45183 ,  H03F2203/45702 ,  H04B10/807 ,  Y02E10/52

Abstract: The present disclosure describes an optically powered transducer with a photovoltaic collector. An optical fiber power delivery method and system and a free space power delivery method are also provided. A fabrication process for making an optically powered transducer is further described, together with an implantable transducer system based on optical power delivery.

Abstract translation: 本公开描述了具有光伏收集器的光学驱动的换能器。 还提供了光纤功率输送方法和系统以及自由空间功率输送方法。 进一步描述制造光学能量换能器的制造过程，以及基于光学功率输送的可植入换能器系统。

公开(公告)号：WO2014007890A3

公开(公告)日：2014-03-27

申请号：PCT/US2013034297

申请日：2013-03-28

Applicant: CALIFORNIA INST OF TECHN

Inventor： RAJAGOPAL ADITYA ,  SCHERER AXEL ,  HENRY MICHAEL D ,  WALAVALKAR SAMEER ,  TOMBRELLO THOMAS A ,  HOMYK ANDREW P

IPC: G01N27/30 ,  G01N27/403

CPC classification number: C12Q1/02 ,  A61B5/04001 ,  G01N27/3275 ,  G01N27/4146 ,  G01R1/06711 ,  G01R1/07342 ,  H01L29/413 ,  H01L29/42376 ,  H01L29/4966 ,  H01L29/66477 ,  H01L29/78 ,  H01L29/7831

Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.

Abstract translation: 本文公开的探针的基本结构和功能允许灵活地并入到探针中，用于各种感测应用的各种感测元件。 这些各种感测应用中的两个示例应用包括生物感测和化学感测应用。 对于生物感测应用，制造在硅衬底上的探针包括诸如纳米柱晶体管的生物感测元件，并且对于化学感测应用，探针包括具有功能化接触区域的感测元件， 当暴露于感兴趣的一种或多种化学品时，感测元件产生电压。

公开(公告)号：EP2948566A4

公开(公告)日：2016-10-05

申请号：EP14743745

申请日：2014-01-23

Applicant: CALIFORNIA INST OF TECHN

Inventor： RAJAGOPAL ADITYA ,  GOLDBERG MARK D ,  GARCIA ERIKA F ,  MADERO XIOMARA L ,  TOMBRELLO THOMAS A ,  SCHERER AXEL

IPC: C12Q1/68

CPC classification number: C12Q1/701 ,  C12Q1/68 ,  C12Q1/6851 ,  C12Q1/703 ,  Y10T436/143333 ,  C12Q2561/113 ,  C12Q2565/101 ,  C12Q2527/101 ,  C12Q2565/1015 ,  C12Q2565/133

Abstract: This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.

Abstract translation: 本公开提供了用于检测样品中多种分析物的方法，组合物和试剂盒。 在一些实例中，本公开提供了用于检测分析物，遗传变异，监测反应过程以及通过测量信号监测分析物 - 分析物相互作用的方法，组合物和试剂盒。 在一些示例中，信号的存在或信号的改变可用于构建可用于检测分析物的信号谱。

公开(公告)号：WO2012129157A3

公开(公告)日：2012-12-27

申请号：PCT/US2012029631

申请日：2012-03-19

Applicant: CALIFORNIA INST OF TECHN ,  WALKER CHRISTOPHER I ,  RAJAGOPAL ADITYA

Inventor： WALKER CHRISTOPHER I ,  RAJAGOPAL ADITYA

IPC: C12M1/38 ,  C12M1/34 ,  C12Q1/68

CPC classification number: B01L3/502707 ,  B01L7/52 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/1827

Abstract: A printed circuit structure containing a fluidic chamber configured to receive an aqueous solution containing a sample to be analyzed and fluorophore for polymerase chain reaction analysis. The printed circuit structure also contains a heating element that provides for temperature cycling of the fluidic chamber to support polymerase chain reaction analysis.

Abstract translation: 一种包含流化室的印刷电路结构，其配置为接收含有待分析样品的水溶液和用于聚合酶链式反应分析的荧光团。 印刷电路结构还包含加热元件，其提供流体室的温度循环以支持聚合酶链式反应分析。

公开(公告)号：WO2012045016A3

公开(公告)日：2012-07-12

申请号：PCT/US2011054366

申请日：2011-09-30

Applicant: CALIFORNIA INST OF TECHN ,  WALAVALKAR SAMEER ,  RAJAGOPAL ADITYA ,  SCHERER AXEL ,  TOMBRELLO THOMAS A

Inventor： WALAVALKAR SAMEER ,  RAJAGOPAL ADITYA ,  SCHERER AXEL ,  TOMBRELLO THOMAS A

IPC: B01D69/00 ,  B01D61/00 ,  B01D71/02

CPC classification number: B01D67/0062 ,  B01D61/027 ,  B01D61/145 ,  B01D69/06 ,  B01D71/027 ,  B07B1/00 ,  B07B1/4618 ,  B81C1/00031 ,  B81C1/00111 ,  B81C1/00119 ,  B81C1/00158 ,  B81C1/00531 ,  B81C1/00539 ,  B82Y40/00 ,  G01N33/48721 ,  H01L21/0331

Abstract: Methods and devices for isolating and sorting nanoparticles are disclosed herein. Nanopores of a desired size can be formed in silicon dioxide membranes and used as filters to separate nanoparticles. Devices are also provided herein for sorting nanoparticles with multiple filters having various sized nanopores.

Abstract translation: 本文公开了用于分离和分选纳米颗粒的方法和装置。 所需尺寸的纳米孔可以在二氧化硅膜中形成并用作分离纳米颗粒的过滤器。 本文还提供了用于对具有各种尺寸的纳米孔的多个过滤器分选纳米颗粒的装置。

公开(公告)号：WO2014007892A3

公开(公告)日：2014-03-27

申请号：PCT/US2013034315

申请日：2013-03-28

Applicant: CALIFORNIA INST OF TECHN

Inventor： RAJAGOPAL ADITYA ,  SCHERER AXEL ,  HENRY MICHAEL D ,  WALAVALKAR SAMEER ,  TOMBRELLO THOMAS ,  HOMYK ANDREW P

IPC: H01L21/336 ,  H01L29/78

CPC classification number: C12Q1/02 ,  A61B5/04001 ,  G01N27/3275 ,  G01N27/4146 ,  G01R1/06711 ,  G01R1/07342 ,  H01L29/413 ,  H01L29/42376 ,  H01L29/4966 ,  H01L29/66477 ,  H01L29/78 ,  H01L29/7831

Abstract: A field effect nano-pillar transistor has a pillar shaped gate element incorporating a biomimitec portion that provides various advantages over prior art devices. The small size of the nano-pillar transistor allows for advantageous insertion into cellular membranes, and the biomimitec character of the gate element operates as an advantageous interface for sensing small amplitude voltages such as transmembrane cell potentials. The nano-pillar transistor can be used in various embodiments to stimulate cells, to measure cell response, or to perform a combination of both actions.

Abstract translation: 场效应纳米柱晶体管具有结合有生物医学部分的柱形门元件，其提供了优于现有技术器件的各种优点。 纳米柱晶体管的小尺寸允许有利地插入到细胞膜中，并且栅极元件的生物学特性作为用于感测小幅度电压（例如跨膜电池电位）的有利接口。 纳米柱晶体管可用于各种实施例中以刺激细胞，测量细胞反应或执行两种动作的组合。

公开(公告)号：WO2012044857A3

公开(公告)日：2012-07-19

申请号：PCT/US2011054074

申请日：2011-09-29

Applicant: CALIFORNIA INST OF TECHN ,  RAJAGOPAL ADITYA ,  SCHERER AXEL ,  TOMBRELLO THOMAS A ,  WALAVALKAR SAMEER ,  HOMYK ANDREW P ,  GARCIA ERIKA

Inventor： RAJAGOPAL ADITYA ,  SCHERER AXEL ,  TOMBRELLO THOMAS A ,  WALAVALKAR SAMEER ,  HOMYK ANDREW P ,  GARCIA ERIKA

IPC: C12Q1/68 ,  C12M1/34 ,  G01N27/26 ,  G01N33/50

CPC classification number: G01N27/447 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N33/48721 ,  C12Q2563/116 ,  C12Q2565/631

Abstract: Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.

Abstract translation: 本文公开了用于测序核酸的方法和装置。 本文还提供了用于测量具有大小允许DNA穿过纳米孔的纳米孔的DNA的装置。 可以测量通过纳米孔的DNA分子的电容。 电容测量可以相关，以确定通过纳米孔的碱基对序列来对DNA进行排序。

公开(公告)号：WO2012145301A3

公开(公告)日：2012-12-27

申请号：PCT/US2012033914

申请日：2012-04-17

Applicant: CALIFORNIA INST OF TECHN ,  CHEN SAMSON ,  RAJAGOPAL ADITYA ,  SCHERER AXEL

Inventor： CHEN SAMSON ,  RAJAGOPAL ADITYA ,  SCHERER AXEL

IPC: G01N35/08 ,  B81B7/00 ,  F04B17/00

CPC classification number: H05K3/10 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  H01L23/473 ,  H01L2924/0002 ,  H05K1/0272 ,  H05K3/284 ,  H05K2201/10189 ,  H05K2203/1327 ,  Y10T29/49 ,  Y10T29/49002 ,  Y10T29/49155 ,  Y10T29/49165 ,  Y10T137/85938 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575 ,  H01L2924/00

Abstract: A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.

Abstract translation: 印刷电路板结构涂覆有密封剂，在密封剂内已经形成微流体通道。 微流体通道通过在封装之前将流体连接焊接到印刷电路板结构的表面上的金属迹线而形成。 在封装后通过蚀刻去除金属迹线以在密封剂内形成微通道。

公开(公告)号：WO2007027663A3

公开(公告)日：2007-06-21

申请号：PCT/US2006033653

申请日：2006-08-28

Applicant: CALIFORNIA INST OF TECHN ,  MALTEZOS GEORGE ,  RAJAGOPAL ADITYA ,  SCHERER AXEL

Inventor： MALTEZOS GEORGE ,  RAJAGOPAL ADITYA ,  SCHERER AXEL

IPC: H01L23/427 ,  B81C1/00 ,  F28D15/04 ,  H01L23/473

CPC classification number: H01L23/427 ,  F25B19/00 ,  F28C3/08 ,  F28D5/00 ,  F28D15/0233 ,  F28D2021/0052 ,  F28F2260/02 ,  H01L23/473 ,  H01L2924/0002 ,  H01L2924/00

Abstract: Evaporative cooling is an effective and efficient method for rapidly removing heat from a system device. In accordance with the disclosure herein, a microfluidic Y-junction apparatus is provided which can produce low temperatures and can be integrated into microdevices.

Abstract translation: 蒸发冷却是快速从系统设备中去除热量的有效和有效的方法。 根据本文的公开内容，提供了可以产生低温并且可以集成到微器件中的微流控Y接合装置。

公开(公告)号：EP2877845A4

公开(公告)日：2016-03-30

申请号：EP13822966

申请日：2013-07-12

Applicant: CALIFORNIA INST OF TECHN ,  SANOFI US

Inventor： RAJAGOPAL ADITYA ,  CHANG CHIEH-FENG ,  PLETTENBURG OLIVER ,  PETRY STEFAN ,  SCHERER AXEL ,  TSCHIRHART CHARLES L

IPC: G01N27/414 ,  B82B3/00 ,  B82Y15/00 ,  G01N33/50 ,  H01L29/06 ,  H01L29/41 ,  H01L29/45 ,  H01L29/49 ,  H01L29/732 ,  H01L29/735 ,  H01L29/78

CPC classification number: H01L29/413 ,  B82Y15/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L29/0676 ,  H01L29/45 ,  H01L29/49 ,  H01L29/73 ,  H01L29/732 ,  H01L29/735 ,  H01L29/78

Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.