公开(公告)号：WO2012045016A3

公开(公告)日：2012-07-12

申请号：PCT/US2011054366

申请日：2011-09-30

Applicant: CALIFORNIA INST OF TECHN ,  WALAVALKAR SAMEER ,  RAJAGOPAL ADITYA ,  SCHERER AXEL ,  TOMBRELLO THOMAS A

Inventor： WALAVALKAR SAMEER ,  RAJAGOPAL ADITYA ,  SCHERER AXEL ,  TOMBRELLO THOMAS A

IPC: B01D69/00 ,  B01D61/00 ,  B01D71/02

CPC classification number: B01D67/0062 ,  B01D61/027 ,  B01D61/145 ,  B01D69/06 ,  B01D71/027 ,  B07B1/00 ,  B07B1/4618 ,  B81C1/00031 ,  B81C1/00111 ,  B81C1/00119 ,  B81C1/00158 ,  B81C1/00531 ,  B81C1/00539 ,  B82Y40/00 ,  G01N33/48721 ,  H01L21/0331

Abstract: Methods and devices for isolating and sorting nanoparticles are disclosed herein. Nanopores of a desired size can be formed in silicon dioxide membranes and used as filters to separate nanoparticles. Devices are also provided herein for sorting nanoparticles with multiple filters having various sized nanopores.

Abstract translation: 本文公开了用于分离和分选纳米颗粒的方法和装置。 所需尺寸的纳米孔可以在二氧化硅膜中形成并用作分离纳米颗粒的过滤器。 本文还提供了用于对具有各种尺寸的纳米孔的多个过滤器分选纳米颗粒的装置。

公开(公告)号：WO2012044857A3

公开(公告)日：2012-07-19

申请号：PCT/US2011054074

申请日：2011-09-29

Applicant: CALIFORNIA INST OF TECHN ,  RAJAGOPAL ADITYA ,  SCHERER AXEL ,  TOMBRELLO THOMAS A ,  WALAVALKAR SAMEER ,  HOMYK ANDREW P ,  GARCIA ERIKA

Inventor： RAJAGOPAL ADITYA ,  SCHERER AXEL ,  TOMBRELLO THOMAS A ,  WALAVALKAR SAMEER ,  HOMYK ANDREW P ,  GARCIA ERIKA

IPC: C12Q1/68 ,  C12M1/34 ,  G01N27/26 ,  G01N33/50

CPC classification number: G01N27/447 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N33/48721 ,  C12Q2563/116 ,  C12Q2565/631

Abstract: Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.

Abstract translation: 本文公开了用于测序核酸的方法和装置。 本文还提供了用于测量具有大小允许DNA穿过纳米孔的纳米孔的DNA的装置。 可以测量通过纳米孔的DNA分子的电容。 电容测量可以相关，以确定通过纳米孔的碱基对序列来对DNA进行排序。

公开(公告)号：WO2010099220A3

公开(公告)日：2010-12-29

申请号：PCT/US2010025261

申请日：2010-02-24

Applicant: CALIFORNIA INST OF TECHN ,  HENRY MICHAEL D ,  HOMYK ANDREW P ,  SCHERER AXEL ,  TOMBRELLO THOMAS A ,  WALAVALKAR SAMEER

Inventor： HENRY MICHAEL D ,  HOMYK ANDREW P ,  SCHERER AXEL ,  TOMBRELLO THOMAS A ,  WALAVALKAR SAMEER

IPC: H01L21/66 ,  H01L21/027

CPC classification number: B81C1/00111 ,  B01J19/0046 ,  B01J2219/00504 ,  B01J2219/00664 ,  B81B1/006 ,  B81B2203/0361 ,  B81B2207/056 ,  B81C2201/0112 ,  B81C2201/0132 ,  B81C2201/0133 ,  B81C2201/0159 ,  G01N1/405 ,  H01L21/3065 ,  H01L21/30655 ,  H01L21/3081 ,  H01L21/3086 ,  Y10T436/25375

Abstract: Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described.

Abstract translation: 描述了制造高纵横比探针和变形微柱和纳米柱的方法。 还描述了聚合物在使纳米柱和微柱变形中的用途。

公开(公告)号：WO2014007890A3

公开(公告)日：2014-03-27

申请号：PCT/US2013034297

申请日：2013-03-28

Applicant: CALIFORNIA INST OF TECHN

Inventor： RAJAGOPAL ADITYA ,  SCHERER AXEL ,  HENRY MICHAEL D ,  WALAVALKAR SAMEER ,  TOMBRELLO THOMAS A ,  HOMYK ANDREW P

IPC: G01N27/30 ,  G01N27/403

CPC classification number: C12Q1/02 ,  A61B5/04001 ,  G01N27/3275 ,  G01N27/4146 ,  G01R1/06711 ,  G01R1/07342 ,  H01L29/413 ,  H01L29/42376 ,  H01L29/4966 ,  H01L29/66477 ,  H01L29/78 ,  H01L29/7831

Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.

Abstract translation: 本文公开的探针的基本结构和功能允许灵活地并入到探针中，用于各种感测应用的各种感测元件。 这些各种感测应用中的两个示例应用包括生物感测和化学感测应用。 对于生物感测应用，制造在硅衬底上的探针包括诸如纳米柱晶体管的生物感测元件，并且对于化学感测应用，探针包括具有功能化接触区域的感测元件， 当暴露于感兴趣的一种或多种化学品时，感测元件产生电压。

公开(公告)号：EP2948566A4

公开(公告)日：2016-10-05

申请号：EP14743745

申请日：2014-01-23

Applicant: CALIFORNIA INST OF TECHN

Inventor： RAJAGOPAL ADITYA ,  GOLDBERG MARK D ,  GARCIA ERIKA F ,  MADERO XIOMARA L ,  TOMBRELLO THOMAS A ,  SCHERER AXEL

IPC: C12Q1/68

CPC classification number: C12Q1/701 ,  C12Q1/68 ,  C12Q1/6851 ,  C12Q1/703 ,  Y10T436/143333 ,  C12Q2561/113 ,  C12Q2565/101 ,  C12Q2527/101 ,  C12Q2565/1015 ,  C12Q2565/133

Abstract: This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.

Abstract translation: 本公开提供了用于检测样品中多种分析物的方法，组合物和试剂盒。 在一些实例中，本公开提供了用于检测分析物，遗传变异，监测反应过程以及通过测量信号监测分析物 - 分析物相互作用的方法，组合物和试剂盒。 在一些示例中，信号的存在或信号的改变可用于构建可用于检测分析物的信号谱。

公开(公告)号：CA2897474A1

公开(公告)日：2014-07-31

申请号：CA2897474

申请日：2014-01-23

Applicant: CALIFORNIA INST OF TECHN

Inventor： RAJAGOPAL ADITYA ,  GOLDBERG MARK D ,  GARCIA ERIKA F ,  MADERO XIOMARA L ,  TOMBRELLO THOMAS A ,  SCHERER AXEL

IPC: C12Q1/68 ,  C12P19/34 ,  C12Q1/70 ,  C40B30/04 ,  C40B70/00

Abstract: This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to determine the presence or absence of analytes.