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    3.
    发明专利
    未知

    公开(公告)号：DK1179585T3

    公开(公告)日：2008-11-10

    申请号：DK01118242

    申请日：1998-12-24

    Applicant: CEPHEID

    Inventor： POURAHMADI FARZAD ,  CHING JESUS ,  CHANG RONALD ,  PETERSEN KURT E ,  MCMILLIAN WILLIAM A ,  CHRISTEL LEE A ,  KOVACS GREGORY T ,  NORTHRUP M ALLEN

    IPC: B01J19/00 ,  G01N31/20 ,  B01D11/00 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  C12M1/26 ,  C12M1/33 ,  C12M1/34 ,  C40B60/14 ,  G01N1/28 ,  G01N30/60 ,  G01N33/50 ,  G01N35/08 ,  G01N37/00

    Abstract: A cartridge (101) for separating a desired analyte from a fluid sample includes a sample port (103) and a sample flow path extending from the port through the body of the cartridge. The sample flow path includes at least one flow-through component (122), e.g. filter paper or a microfabricated chip, for capturing the desired analyte from the sample as the sample flows through the cartridge. The cartridge also includes an elution flow path for carrying elution fluid through the component (122) to release captured analyte from the component into the elution fluid. The elution flow path diverges from the sample flow path after passing through the component (122). Flow controllers (41A and 41B) direct the remaining fluid sample into a waste chamber (139) after the sample flows through the component (122) and direct the elution fluid and eluted analyte into a reagent chamber (141) and reaction chamber (143). The continuous-flow design of the cartridge permits the rapid processing of a fluid sample that is larger in volume than any interactive region within the cartridge, allowing increased sensitivity in the detection of low copy concentrations of analytes, such as nucleic acid. A preferred embodiment relates to a device for lysing components of a fluid sample, the device comprising inter alia, an ultrasonic transducer.

    5.
    发明专利
    未知

    公开(公告)号：DE69839709D1

    公开(公告)日：2008-08-21

    申请号：DE69839709

    申请日：1998-12-24

    Applicant: CEPHEID

    Inventor： POURAHMADI FARZAD ,  MCMILLIAN WILLIAM A ,  CHING JESUS ,  CHANG RONALD ,  CHRISTEL LEE A ,  KOVACS GREGORY T ,  NORTHRUP M ALLEN ,  PETERSEN KURT E

    IPC: B01J19/00 ,  G01N31/20 ,  B01D11/00 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  C12M1/26 ,  C12M1/33 ,  C12M1/34 ,  C40B60/14 ,  G01N1/28 ,  G01N30/60 ,  G01N33/50 ,  G01N35/08 ,  G01N37/00

    Abstract: A cartridge (101) for separating a desired analyte from a fluid sample includes a sample port (103) and a sample flow path extending from the port through the body of the cartridge. The sample flow path includes at least one flow-through component (122), e.g. filter paper or a microfabricated chip, for capturing the desired analyte from the sample as the sample flows through the cartridge. The cartridge also includes an elution flow path for carrying elution fluid through the component (122) to release captured analyte from the component into the elution fluid. The elution flow path diverges from the sample flow path after passing through the component (122). Flow controllers (41A and 41B) direct the remaining fluid sample into a waste chamber (139) after the sample flows through the component (122) and direct the elution fluid and eluted analyte into a reagent chamber (141) and reaction chamber (143). The continuous-flow design of the cartridge permits the rapid processing of a fluid sample that is larger in volume than any interactive region within the cartridge, allowing increased sensitivity in the detection of low copy concentrations of analytes, such as nucleic acid. A preferred embodiment relates to a device for lysing components of a fluid sample, the device comprising inter alia, an ultrasonic transducer.

    6.
    发明专利
    未知

    公开(公告)号：AT400358T

    公开(公告)日：2008-07-15

    申请号：AT01118242

    申请日：1998-12-24

    Applicant: CEPHEID

    Inventor： POURAHMADI FARZAD ,  MCMILLIAN WILLIAM A ,  CHING JESUS ,  CHANG RONALD ,  CHRISTEL LEE A ,  KOVACS GREGORY T ,  NORTHRUP M ALLEN ,  PETERSEN KURT E

    IPC: B01J19/00 ,  G01N31/20 ,  B01D11/00 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  C12M1/26 ,  C12M1/33 ,  C12M1/34 ,  C40B60/14 ,  G01N1/28 ,  G01N30/60 ,  G01N33/50 ,  G01N35/08 ,  G01N37/00

    Abstract: A cartridge (101) for separating a desired analyte from a fluid sample includes a sample port (103) and a sample flow path extending from the port through the body of the cartridge. The sample flow path includes at least one flow-through component (122), e.g. filter paper or a microfabricated chip, for capturing the desired analyte from the sample as the sample flows through the cartridge. The cartridge also includes an elution flow path for carrying elution fluid through the component (122) to release captured analyte from the component into the elution fluid. The elution flow path diverges from the sample flow path after passing through the component (122). Flow controllers (41A and 41B) direct the remaining fluid sample into a waste chamber (139) after the sample flows through the component (122) and direct the elution fluid and eluted analyte into a reagent chamber (141) and reaction chamber (143). The continuous-flow design of the cartridge permits the rapid processing of a fluid sample that is larger in volume than any interactive region within the cartridge, allowing increased sensitivity in the detection of low copy concentrations of analytes, such as nucleic acid. A preferred embodiment relates to a device for lysing components of a fluid sample, the device comprising inter alia, an ultrasonic transducer.

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