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    CHEMICAL IMAGING EXPLOSIVES (CHIMED) OPTICAL SENSOR
    2.
    发明申请
    CHEMICAL IMAGING EXPLOSIVES (CHIMED) OPTICAL SENSOR 审中-公开
    化学成像爆炸物（CH）光学传感器

    公开(公告)号：WO2008002324A3

    公开(公告)日：2008-06-19

    申请号：PCT/US2006049176

    申请日：2006-12-22

    Applicant: CHEMIMAGE CORP ,  NELSON MATTHEW ,  TREADO PATRICK J

    Inventor： NELSON MATTHEW ,  TREADO PATRICK J

    IPC: G01J3/30

    CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0218 ,  G01N21/6456 ,  G01N21/65 ,  G01N33/227 ,  G01N2001/024 ,  G01N2021/6417 ,  G01N2021/6484

    Abstract: A system and method of detecting explosive compounds located on a sample. The sample includes items such as a human hand, a passport, a credit card, a driver's license, a boarding pass, a human body part, a human clothing, a human-wearable item, and an airline ticket. The sample is irradiated with animal-safe ultra-violet radiation generating a fluorescence data set. A fluorescence database is searched based on the fluorescence data set in order to identify a known fluorescence data set. If the searching of the fluorescence database identifies a known fluorescence data set, an area of interest in the sample is identified based on the known fluorescence data set identified in the fluorescence database searching. The area of interest is irradiated with substantially monochromatic radiation to generate a Raman data set of the area of interest. A Raman database is searched based on the Raman data set in order to identify a known Raman data set. An explosive compound in the area of interest is identified based on the known Raman data set identified by searching the Raman database.

    Abstract translation: 检测位于样品上的爆炸性化合物的系统和方法。 样本包括诸如人手，护照，信用卡，驾驶执照，登机牌，人体部位，人体衣服，人体可穿戴物品和机票等物品。 使用产生荧光数据集的动物安全的紫外辐射照射样本。 基于荧光数据集搜索荧光数据库以识别已知的荧光数据集。 如果荧光数据库的搜索识别已知的荧光数据组，则基于在荧光数据库搜索中识别的已知荧光数据集来识别样本中的感兴趣区域。 用基本上单色的辐射照射感兴趣的区域以产生感兴趣区域的拉曼数据组。 基于拉曼数据集搜索拉曼数据库以识别已知的拉曼数据集。 根据通过搜索拉曼数据库确定的已知拉曼数据集确定感兴趣区域内的爆炸性化合物。

    AUTOMATED ACQUISITION OF SPECTRAL DATA AND IMAGE DATA
    3.
    发明申请
    AUTOMATED ACQUISITION OF SPECTRAL DATA AND IMAGE DATA 审中-公开
    自动采集光谱数据和图像数据

    公开(公告)号：WO2007050602A3

    公开(公告)日：2009-05-14

    申请号：PCT/US2006041471

    申请日：2006-10-24

    Applicant: CHEMIMAGE CORP ,  MAIER JOHN S ,  TREADO PATRICK J ,  NELSON MATTHEW ,  MCCLELLAND LINDY ,  STEWART SHONA

    Inventor： MAIER JOHN S ,  TREADO PATRICK J ,  NELSON MATTHEW ,  MCCLELLAND LINDY ,  STEWART SHONA

    IPC: G01J3/44 ,  G06F19/00 ,  H04B10/08 ,  H04B17/00

    CPC classification number: G01N21/65 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/274 ,  G01N2021/656

    Abstract: A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.

    Abstract translation: 自动获取样品光谱的系统和方法。 该方法涉及包括光漂白相和光谱采集阶段的两相过程。 在漂白漂白阶段，收集样品的一系列光谱数据集。 在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。 如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。 在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

    METHOD AND SYSTEM FOR COMBINED RAMAN AND LIBS DETECTION
    4.
    发明申请
    METHOD AND SYSTEM FOR COMBINED RAMAN AND LIBS DETECTION 审中-公开
    用于组合拉曼和LIBS检测的方法和系统

    公开(公告)号：WO2007087315A3

    公开(公告)日：2008-07-31

    申请号：PCT/US2007001799

    申请日：2007-01-23

    Applicant: CHEMIMAGE CORP ,  BECKSTEAD JEFFREY ,  TREADO PATRICK J ,  NELSON MATTHEW ,  HUBBLE HUGH W II ,  NEISS JASON

    Inventor： BECKSTEAD JEFFREY ,  TREADO PATRICK J ,  NELSON MATTHEW ,  HUBBLE HUGH W II ,  NEISS JASON

    IPC: G01J3/44

    CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/28 ,  G01J3/443 ,  G01N21/65 ,  G01N21/718

    Abstract: In one embodiment, the disclosure relates to a method for interrogating a sample by: illuminating a first region of the sample with a first illumination pattern to obtain a plurality of first sample photons; illuminating a second region of the sample with a second illumination pattern to obtain a plurality of second sample photons; processing the plurality of first sample photons to obtain a characteristic atomic emission of the first region and processing the plurality of second sample photons to obtain a Raman spectrum; and identifying the sample through at least one of the characteristic atomic emission of the first region or the Raman spectrum of the second region of the sample.

    Abstract translation: 在一个实施例中，本公开涉及一种用于询问样本的方法，其中：用第一照明图案照射样品的第一区域以获得多个第一样品光子; 用第二照明图案照射样品的第二区域以获得多个第二样品光子; 处理多个第一样品光子以获得第一区域的特征原子发射并处理多个第二样品光子以获得拉曼光谱; 以及通过样品的第二区域的第一区域的特征性原子发射或拉曼光谱中的至少一个来识别样品。

    METHOD OF CHEMICAL IMAGING TO DETERMINE TISSUE MARGINS DURING SURGERY
    5.
    发明申请
    METHOD OF CHEMICAL IMAGING TO DETERMINE TISSUE MARGINS DURING SURGERY 审中-公开
    化学成像在手术期间确定组织标记的方法

    公开(公告)号：WO2006091853A3

    公开(公告)日：2008-05-08

    申请号：PCT/US2006006663

    申请日：2006-02-24

    Applicant: CHEMIMAGE CORP ,  MAIER JOHN S ,  STEWART SHONA ,  COHEN JEFFREY ,  NELSON MATTHEW

    Inventor： MAIER JOHN S ,  STEWART SHONA ,  COHEN JEFFREY ,  NELSON MATTHEW

    IPC: A61B6/00

    CPC classification number: G01N21/65 ,  A61B5/0075 ,  A61B5/0084 ,  G01N2021/6484 ,  G01N2021/656 ,  G01N2201/08

    Abstract: A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.

    Abstract translation: 在各种医疗过程中区分组织边缘的方法和系统。 用基本上单色的光照射含有生物组织的区域。 从照射区域获得拉曼光谱数据。 在包含生物组织的区域中的肿瘤部分和非肿瘤部分之间的边界通过评估肿瘤部分或非肿瘤部分的至少一个拉曼光谱值特征的拉曼光谱数据来区分。 基于肿瘤部分和非肿瘤部分之间的边界的分化，选择肿瘤部分用于物理操作。

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