Patent search ap:("COR THERAPEUTICS INC") AND inv:"KANE-MAGUIRE KIM" Page 1

1.

发明申请
INHIBITORS OF FACTOR Xa 审中-公开
Title translation: 因子的抑制剂Xa

公开(公告)号：WO0112600A9

公开(公告)日：2002-09-12

申请号：PCT/US0021742

申请日：2000-08-10

Applicant: COR THERAPEUTICS INC , ZHU BING-YAN , SCARBOROUGH ROBERT M , CLIZBE LANE , DOUGHAN BRANDON , JIA ZHAOZHONG-JON , KANE-MAGUIRE KIM , MARLOWE CHARLES , SONG YONGHONG , SU TING , TENG WILLY , ZHANG PENGLIE

Inventor： ZHU BING-YAN , SCARBOROUGH ROBERT M , CLIZBE LANE , DOUGHAN BRANDON , JIA ZHAOZHONG-JON , KANE-MAGUIRE KIM , MARLOWE CHARLES , SONG YONGHONG , SU TING , TENG WILLY , ZHANG PENGLIE

IPC: C07D209/08 , C07D209/34 , C07D209/38 , C07D215/08 , C07D215/22 , C07D215/227 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/38 , C07D241/44 , C07D243/24 , C07D265/36 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D209/04 , C07D215/00 , C07D235/04 , C07D241/36 , C07D403/02 , C07D498/02

CPC classification number: C07D215/227 , C07D209/08 , C07D209/34 , C07D209/38 , C07D215/08 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/38 , C07D241/44 , C07D243/24 , C07D265/36 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of formula (I) are useful in vitro or in vivo for preventing or treating coagulation disorders.

Abstract translation: 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。式（I）化合物在体外或体内可用于预防或治疗凝血障碍。

2.

发明申请
INHIBITORS OF FACTOR Xa 审中-公开
Title translation: 因子的抑制剂Xa

公开(公告)号：WO0071511A3

公开(公告)日：2001-08-09

申请号：PCT/US0014205

申请日：2000-05-24

Applicant: COR THERAPEUTICS INC

Inventor： SU TING , ZHU BING-YAN , KANE-MAGUIRE KIM , SCARBOROUGH ROBERT M , ZHANG PENGLIE

IPC: C07D213/74 , A61K31/18 , A61K31/198 , A61K31/341 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4164 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07C311/16 , C07C311/21 , C07C311/46 , C07D205/04 , C07D207/16 , C07D207/20 , C07D207/325 , C07D213/40 , C07D213/64 , C07D213/72 , C07D213/75 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/68 , C07D295/18 , C07D295/192 , C07D295/22 , C07D295/26 , C07D307/38 , C07D307/52 , C07D401/12 , A61K31/277 , A61K31/501

CPC classification number: C07D213/40 , C07C311/16 , C07C311/46 , C07D217/22 , C07D295/192 , C07D295/26 , C07D307/52 , C07D401/12

Abstract: Compounds of the formula A - Y - D - E - G - J - Z - L in which D is a direct link, a substituted or unsubstituted phenyl or naphtyl group or a heterocyclic ring system; Z is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

Abstract translation: 式A-Y-D-E-G-J-Z-L的化合物，其中D是直链，取代或未取代的苯基或萘基或杂环系; Z是取代或未取代的苯基或萘基或杂环系; 并且其它变量如权利要求中所定义，公开了其与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。该化合物在体外或体内可用于预防或治疗凝血障碍。

3.

发明专利
Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions and method of use thereof 未知

公开(公告)号：AU3927702A

公开(公告)日：2002-05-27

申请号：AU3927702

申请日：2001-11-20

Applicant: COR THERAPEUTICS INC

Inventor： LEVY DANIEL E , MARLOWE CHARLES , KANE-MAGUIRE KIM , SCARBOROUGH ROBERT M JR

IPC: C07D473/34 , C07D473/00

Abstract: The present invention relates to derivatives and analogues of adenine of the formula: wherein L, A, Y and Z are those defined herein. Compounds of the present invention are useful in inhibiting adenylyl cyclase activity. The present invention also relates to a method of preventing and inhibiting a patient's fibroproliferative vasculopathy following vascular injury or a vascular surgical operation which includes administering to the patient, an effective amount of a compound according to the invention subsequent to a vascular injury, or subsequent to a vascular surgical operation, for one to two weeks after the injury or surgical operation, effective to treat or prevent a patient's fibroproliferative vasculopathy such as chronic allograft rejection or vascular restenosis following vascular trauma. The present invention also relates to a method for measuring the inhibition of adenylyl cyclase activity and a method for treating congestive heart failure.

4.

发明申请
INHIBITORS OF FACTOR Xa 审中-公开
Title translation: 因子的抑制剂Xa

公开(公告)号：WO0071510A3

公开(公告)日：2001-08-30

申请号：PCT/US0014195

申请日：2000-05-24

Applicant: COR THERAPEUTICS INC

Inventor： SU TING , ZHU BING-YAN , KANE-MAGUIRE KIM , SCARBOROUGH ROBERT M , ZHANG PENGLIE

IPC: C07D213/74 , A61K31/18 , A61K31/198 , A61K31/341 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4164 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07C311/16 , C07C311/21 , C07C311/46 , C07D205/04 , C07D207/16 , C07D207/20 , C07D207/325 , C07D213/40 , C07D213/64 , C07D213/72 , C07D213/75 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/68 , C07D295/18 , C07D295/192 , C07D295/22 , C07D295/26 , C07D307/38 , C07D307/52 , C07D401/12 , A61K31/33 , C07D207/22 , C07D207/32

CPC classification number: C07D213/40 , C07C311/16 , C07C311/46 , C07D217/22 , C07D295/192 , C07D295/26 , C07D307/52 , C07D401/12

Abstract: Compounds of formula A - Y - D - E - G - J - Z - L in which D is direct link, a substutited or unsubstituted phenyl or napththyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions relating thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

Abstract translation: 式A-Y-D-E-G-J-Z-L的化合物，其中D是直链，取代或未取代的苯基或萘乙基或杂环系统; 并且其它变量如权利要求中所定义，公开了其与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。该化合物在体外或体内可用于预防或治疗凝血障碍。

5.

发明专利
INHIBITORS OF FACTOR XA 未知

公开(公告)号：CA2374947A1

公开(公告)日：2000-11-30

申请号：CA2374947

申请日：2000-05-24

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M , ZHANG PENGLIE , ZHU BING-YAN , KANE-MAGUIRE KIM , SU TING

IPC: C07D213/74 , A61K31/18 , A61K31/198 , A61K31/341 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4164 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07C311/16 , C07C311/21 , C07C311/46 , C07D205/04 , C07D207/16 , C07D207/20 , C07D207/325 , C07D213/40 , C07D213/64 , C07D213/72 , C07D213/75 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/68 , C07D295/18 , C07D295/192 , C07D295/22 , C07D295/26 , C07D307/38 , C07D307/52 , C07D401/12 , A61K31/33 , C07D207/22 , C07D207/32

Abstract: Compounds of formula A - Y - D - E - G - J - Z - L in which D is direct link , a substutited or unsubstituted phenyl or napththyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their sal ts and compositions relating thereto having activity against mammalian factor X a are disclosed. The compounds are useful in vitro or in vivo for preventing o r treating coagulation disorders.

6.

发明专利
INHIBITORS OF FACTOR XA 未知

公开(公告)号：CA2374793A1

公开(公告)日：2000-11-30

申请号：CA2374793

申请日：2000-05-24

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M , KANE-MAGUIRE KIM , ZHU BING-YAN , SU TING , ZHANG PENGLIE

IPC: C07D213/74 , A61K31/18 , A61K31/198 , A61K31/341 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4164 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07C311/16 , C07C311/21 , C07C311/46 , C07D205/04 , C07D207/16 , C07D207/20 , C07D207/325 , C07D213/40 , C07D213/64 , C07D213/72 , C07D213/75 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/68 , C07D295/18 , C07D295/192 , C07D295/22 , C07D295/26 , C07D307/38 , C07D307/52 , C07D401/12 , A61K31/277 , A61K31/501

Abstract: Compounds of the formula A - Y - D - E - G - J - Z - L in which D is a direc t link, a substituted or unsubstituted phenyl or naphtyl group or a heterocycl ic ring system; Z is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.