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公开(公告)号：WO0071507A3
公开(公告)日：2001-11-15
申请号：PCT/US0014196
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SU TING , ZHAOZHONG JON JIA , SCARBOROUGH ROBERT M , SONG YONGHONG
IPC: A61P7/02 , A61K31/167 , A61K31/18 , A61K31/275 , A61K31/277 , A61K31/40 , A61K31/472 , A61K31/4725 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/16 , C07C311/18 , C07C311/40 , C07C311/44 , C07C311/46 , C07D207/16 , C07D217/22 , C07D401/06
CPC classification number: C07C311/40 , C07C311/16 , C07C311/18 , C07C311/44 , C07C311/46
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 该化合物可用于体内或体内用于预防或治疗凝血障碍。
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公开(公告)号：WO0071510A3
公开(公告)日：2001-08-30
申请号：PCT/US0014195
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： SU TING , ZHU BING-YAN , KANE-MAGUIRE KIM , SCARBOROUGH ROBERT M , ZHANG PENGLIE
IPC: C07D213/74 , A61K31/18 , A61K31/198 , A61K31/341 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4164 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07C311/16 , C07C311/21 , C07C311/46 , C07D205/04 , C07D207/16 , C07D207/20 , C07D207/325 , C07D213/40 , C07D213/64 , C07D213/72 , C07D213/75 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/68 , C07D295/18 , C07D295/192 , C07D295/22 , C07D295/26 , C07D307/38 , C07D307/52 , C07D401/12 , A61K31/33 , C07D207/22 , C07D207/32
CPC classification number: C07D213/40 , C07C311/16 , C07C311/46 , C07D217/22 , C07D295/192 , C07D295/26 , C07D307/52 , C07D401/12
Abstract: Compounds of formula A - Y - D - E - G - J - Z - L in which D is direct link, a substutited or unsubstituted phenyl or napththyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions relating thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 式A-Y-D-E-G-J-Z-L的化合物，其中D是直链，取代或未取代的苯基或萘乙基或杂环系统; 并且其它变量如权利要求中所定义，公开了其与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0112600A9
公开(公告)日：2002-09-12
申请号：PCT/US0021742
申请日：2000-08-10
Applicant: COR THERAPEUTICS INC , ZHU BING-YAN , SCARBOROUGH ROBERT M , CLIZBE LANE , DOUGHAN BRANDON , JIA ZHAOZHONG-JON , KANE-MAGUIRE KIM , MARLOWE CHARLES , SONG YONGHONG , SU TING , TENG WILLY , ZHANG PENGLIE
Inventor： ZHU BING-YAN , SCARBOROUGH ROBERT M , CLIZBE LANE , DOUGHAN BRANDON , JIA ZHAOZHONG-JON , KANE-MAGUIRE KIM , MARLOWE CHARLES , SONG YONGHONG , SU TING , TENG WILLY , ZHANG PENGLIE
IPC: C07D209/08 , C07D209/34 , C07D209/38 , C07D215/08 , C07D215/22 , C07D215/227 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/38 , C07D241/44 , C07D243/24 , C07D265/36 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D209/04 , C07D215/00 , C07D235/04 , C07D241/36 , C07D403/02 , C07D498/02
CPC classification number: C07D215/227 , C07D209/08 , C07D209/34 , C07D209/38 , C07D215/08 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/38 , C07D241/44 , C07D243/24 , C07D265/36 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of formula (I) are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 式（I）化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0047554A3
公开(公告)日：2001-08-09
申请号：PCT/US0003405
申请日：2000-02-11
Applicant: COR THERAPEUTICS INC
Inventor： SONG YONGHONG , ZHU BING-YAN , SCARBOROUGH ROBERT M , CLIZBE LANE , JIA ZHAOZHONG JON , SU TING , TENG WILLY
IPC: C07D295/14 , A61K31/18 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/341 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4174 , A61K31/44 , A61K31/4409 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/505 , A61K31/517 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P31/04 , A61P43/00 , C07C257/18 , C07C311/29 , C07C311/46 , C07C311/51 , C07D213/56 , C07D213/58 , C07D213/70 , C07D213/74 , C07D213/75 , C07D217/22 , C07D231/12 , C07D233/61 , C07D239/42 , C07D239/94 , C07D257/04 , C07D295/16 , C07D307/54 , C07D401/12 , C07D521/00 , A61K31/16 , A61K31/33 , C07D231/56
CPC classification number: C07D231/12 , C07C311/46 , C07C311/51 , C07C2601/10 , C07D217/22 , C07D233/56 , C07D239/94 , C07D249/08 , C07D307/54 , C07D401/12
Abstract: Novel compounds of formula in which A is a substituted or unsubstituted phenyl, naphthyl or monocyclic heterocyclic ring, D is a substituted or unsubstituted phenyl or aromatic six-membered heterocyclic ring, K is a substituted or unsubstituted phenyl, naphthyl or bicyclic heterocyclic ring, and the other variables are as defined in the claims, their salts and other derivatives and compositions related thereto having activity against mammalian Factor Xa are disclosed. The coumpounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 其中A是取代或未取代的苯基，萘基或单环杂环的新型式的化合物，D是取代或未取代的苯基或芳族六元杂环，K是取代或未取代的苯基，萘基或双环杂环，以及 其他变量如权利要求中所定义，公开了其与其相关的盐和其它衍生物和组合物具有抗哺乳动物因子Xa的活性。 固体在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0071493A3
公开(公告)日：2002-01-17
申请号：PCT/US0014138
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SU TING , ZHAOZHANG JON JIA , SCARBOROUGH ROBERT M , SONG YONGHONG
IPC: A61P7/02 , A61K31/167 , A61K31/18 , A61K31/275 , A61K31/277 , A61K31/40 , A61K31/472 , A61K31/4725 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/16 , C07C311/18 , C07C311/40 , C07C311/44 , C07C311/46 , C07D207/16 , C07D217/22 , C07D401/06
CPC classification number: C07C311/40 , C07C311/16 , C07C311/18 , C07C311/44 , C07C311/46
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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Patent Agency Ranking
公开(公告)号：WO0071511A3
公开(公告)日：2001-08-09
申请号：PCT/US0014205
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： SU TING , ZHU BING-YAN , KANE-MAGUIRE KIM , SCARBOROUGH ROBERT M , ZHANG PENGLIE
IPC: C07D213/74 , A61K31/18 , A61K31/198 , A61K31/341 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4164 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07C311/16 , C07C311/21 , C07C311/46 , C07D205/04 , C07D207/16 , C07D207/20 , C07D207/325 , C07D213/40 , C07D213/64 , C07D213/72 , C07D213/75 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/68 , C07D295/18 , C07D295/192 , C07D295/22 , C07D295/26 , C07D307/38 , C07D307/52 , C07D401/12 , A61K31/277 , A61K31/501
CPC classification number: C07D213/40 , C07C311/16 , C07C311/46 , C07D217/22 , C07D295/192 , C07D295/26 , C07D307/52 , C07D401/12
Abstract: Compounds of the formula A - Y - D - E - G - J - Z - L in which D is a direct link, a substituted or unsubstituted phenyl or naphtyl group or a heterocyclic ring system; Z is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 式A-Y-D-E-G-J-Z-L的化合物，其中D是直链，取代或未取代的苯基或萘基或杂环系; Z是取代或未取代的苯基或萘基或杂环系; 并且其它变量如权利要求中所定义，公开了其与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：NZ500353A
公开(公告)日：2002-02-01
申请号：NZ50035398
申请日：1998-04-13
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SCARBOROUGH ROBERT M , SU TING
IPC: A61K38/00 , A61K8/63 , A61P7/02 , A61P9/02 , A61P9/10 , A61Q7/00 , A61Q7/02 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/072 , C07K5/078 , C07K5/04 , A61K38/04 , C07D245/02
Abstract: Compounds of general formula (I) having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：AU5158100A
公开(公告)日：2000-12-12
申请号：AU5158100
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： SONG YONGHONG , CLIZBE LANE , MARLOWE CHARLES , SCARBOROUGH ROBERT M JR , SU TING , ZHU BING-YAN , KANTER JAMES
IPC: C07D233/61 , A61K31/165 , A61K31/167 , A61K31/18 , A61K31/198 , A61K31/216 , A61K31/277 , A61K31/341 , A61K31/40 , A61K31/404 , A61K31/415 , A61K31/422 , A61K31/4402 , A61K31/472 , A61K33/22 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P43/00 , C07C311/46 , C07C317/32 , C07D209/08 , C07D213/56 , C07D217/22 , C07D231/12 , C07D295/16 , C07D307/54 , C07D307/68 , C07D413/04 , C07D521/00
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公开(公告)号：BR0107282A
公开(公告)日：2004-07-06
申请号：BR0107282
申请日：2001-10-01
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SU TING , LI WENHAO , GOLDMAN ERICK A , ZHANG PENGLIE , JIA ZHAOZHONG JON , SCARBOROUGH ROBERT M
IPC: C07D241/06 , A61K31/438 , A61K31/495 , A61K31/496 , A61P7/02 , A61P9/00 , A61P9/10 , C07D241/08 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D491/10 , C07D491/113 , C07D401/12
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公开(公告)号：CA2382751A1
公开(公告)日：2000-11-30
申请号：CA2382751
申请日：2000-05-24
Applicant: COR THERAPEUTICS INC
Inventor： CLIZBE LANE , SONG YONGHONG , MARLOWE CHARLES , ZHU BING-YAN , SU TING , SCARBOROUGH ROBERT M
IPC: C07D233/61 , A61K31/165 , A61K31/167 , A61K31/18 , A61K31/198 , A61K31/216 , A61K31/277 , A61K31/341 , A61K31/40 , A61K31/404 , A61K31/415 , A61K31/422 , A61K31/4402 , A61K31/472 , A61K33/22 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P43/00 , C07C311/46 , C07C317/32 , C07D209/08 , C07D213/56 , C07D217/22 , C07D231/12 , C07D295/16 , C07D307/54 , C07D307/68 , C07D413/04 , C07D521/00
Abstract: The present application relates to compounds of the general formula A-Y-D-E- G- J-K-L, wherein A, Y, D, E, G, J, K and L have the meanings given in the description, having activity against mammalian factor Xa. The compounds are useful in vitroor in vivofor preventing or treating coagulation disorders.
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