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公开(公告)号：WO9963972A9
公开(公告)日：2000-10-12
申请号：PCT/US9912772
申请日：1999-06-08
Applicant: DELSYS PHARMACEUTICAL CORP , CHEN JEN CHI , CHRAI SUGGY S , DESAI NITIN VITHALBHAI , HAMMER LAWRENCE HARRISON , KELLER DAVID , KUMAR NALIN , LAL PRINCE , LEVINE AARON WILLIAM , MURARI RAMASWAMY , MARA KERRY DENNIS O , POLINIAK EUGENE SAMUEL , RIVENBURG HOWARD CHRISTOPHER , ROACH WILLIAM RONALD , ROSATI DOMINIC STEPHEN , SINGH BAWA , SOUTHGATE PETER DAVID , SUN HOI CHEONG , ZANZUCCHI PETER JOHN
Inventor： CHEN JEN-CHI , CHRAI SUGGY S , DESAI NITIN VITHALBHAI , HAMMER LAWRENCE HARRISON , KELLER DAVID , KUMAR NALIN , LAL PRINCE , LEVINE AARON WILLIAM , MURARI RAMASWAMY , O'MARA KERRY DENNIS , POLINIAK EUGENE SAMUEL , RIVENBURG HOWARD CHRISTOPHER , ROACH WILLIAM RONALD , ROSATI DOMINIC STEPHEN , SINGH BAWA , SOUTHGATE PETER DAVID , SUN HOI CHEONG , ZANZUCCHI PETER JOHN
IPC: A61K9/14 , A61J1/03 , A61J3/00 , A61K9/16 , A61K9/51 , A61K9/70 , B05B5/025 , B05B5/08 , B05B5/16 , B65B1/04 , B65B1/30 , B65B11/50
CPC classification number: A61K9/70 , A61J1/035 , A61J3/00 , B05B5/08 , B65B1/04 , B65B1/30 , B65B11/50
Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit and is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.
Abstract translation: 本发明提供了一种产品（1），其包括药物单位剂量或诊断形式（6），其包含至少一种活性成分，其有效量不超过预定目标量的约5％ 。 在一个实施例中，单元形式包括衬底（8），设置在衬底上的沉积物（14）和覆盖在沉积物上的覆盖层（9），并且通过围绕该沉积物的键与衬底接合， 从而将其封装在基板和盖基板之间。 沉积物包含粉末，其中至少一些包括至少一种活性成分。 单元形式通过干粉沉积设备产生，其使用静电卡盘和带电粉末输送装置将粉末静电沉积在基底上。
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公开(公告)号：EP1210760A4
公开(公告)日：2003-05-21
申请号：EP00974094
申请日：2000-09-11
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： SUN HOI CHEONG , SINGH BAWA , RIVENBURG HOWARD CHRISTOPHER
CPC classification number: B82Y15/00 , B01J2219/00468 , B01J2219/005 , H02N1/004
Abstract: A charged particle (Bead) is moved from a first electrode (9) to a second electrode (10) also with the aid of a guide electrode (Guide Electrode).
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公开(公告)号：EP1121752A4
公开(公告)日：2003-05-21
申请号：EP99953173
申请日：1999-10-14
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： SUN HOI CHEONG , DESAI NITIN V , ROACH WILLIAM R , LUDINGTON DAVID N , PLETCHER TIMOTHY A , KELLER DAVID , LANG FRANK B , SOUTHGATE PETER D , MCGINN JOSEPH T
IPC: H01L21/683 , H02N13/00
CPC classification number: H01L21/6833 , H02N13/00
Abstract: Provided is an electrostatic sensing chuck for attracting particles to a portion of a particle contact surface near a deposition electrode, the electrostatic sensing chuck comprising a pixel comprising: a deposition electrode (DE) for selectively establishing an attraction field (Ea) at the particle contact surface; a shield electrode (SE) oppositely biased with respect to the deposition electrode; a charge sensing circuit to measure charge accumulated on each of the deposition electrode and the shield electrode, wherein the charge sensing circuit subtracts a second charge it senses at the shield electrode from a first charge it senses at the deposition electrode, thereby determining accumulated charge at the deposition electrode balanced by accumulated charge at the shield electrode.
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4.发明公开BEAD MANIPULATING CHUCKS WITH BEAD SIZE SELECTOR 审中-公开HANDHABUNGSVORRICHTUNGFÜRKÜGELCHENMITKÜGELCHENGRÖSSENSELEKTOR
公开(公告)号：EP1066609A4
公开(公告)日：2003-05-21
申请号：EP99914150
申请日：1999-03-25
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： SUN HOI CHEONG
CPC classification number: B82Y15/00 , B01J19/0046 , B01J2219/00468 , B01J2219/005 , B65G47/90
Abstract: Bead manipulating chucks for selective pick up and discharge of polymer beads for chemical synthesis, whereby bead collection zones (BCZ) are recessed from bead contact surfaces (BCS). A voltage can be applied to a bead electrode (9) relative to shield material (10) to allow attraction of beads to the bead collection zone (BCZ). The strong dependence of the electrostatic image force on bead diameters provides a mechanism that selects bead sizes that are retained by the bead manipulating chuck.
Abstract translation: 珠子操纵卡盘用于选择性提取和排出聚合物珠子进行化学合成，珠粒收集区（BCZ）从珠子接触表面（BCS）凹进。 可以将电压施加到相对于屏蔽材料（10）的珠状电极（9）以允许珠粒吸引到珠粒收集区域（BCZ）。 静电图像力对珠粒直径的强烈依赖性提供了选择珠粒操作卡盘保持的珠粒尺寸的机制。
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公开(公告)号：HU0102753A2
公开(公告)日：2001-11-28
申请号：HU0102753
申请日：1999-06-08
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： CHEN JEN-CHI , CHRAI SUGGY S , DESAI NITIN VITHALBHAI , HAMMER LAWRENCE HARRISON , KELLER DAVID , KUMAR NALIN , LAL PRINCE , LEVINE AARON WILLIAM , MURARI RAMASWAMY , O'MARA KERRY DENNIS , POLINIAK EUGENE SAMUEL , RIVENBURG HOWARD CHRISTOPHER , ROACH WILLIAM RONALD , ROSATI DOMINIC STEPHEN , SINGH BAWA , SOUTHGATE PETER DAVID , SUN HOI CHEONG , ZANZUCCHI PETER JOHN
IPC: A61K9/14 , A61J1/03 , A61J3/00 , A61K9/16 , A61K9/51 , A61K9/70 , B05B5/025 , B05B5/08 , B05B5/16 , B65B1/04 , B65B1/30 , B65B11/50
Abstract: The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit and is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.
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Patent Agency Ranking
公开(公告)号：CA2383893A1
公开(公告)日：2001-03-15
申请号：CA2383893
申请日：2000-09-11
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： RIVENBURG HOWARD CHRISTOPHER , SINGH BAWA , SUN HOI CHEONG
Abstract: A charged particle (Bead) is moved from a first electrode (9) to a second electrode (10) also with the aid of a guide electrode (Guide Electrode).
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公开(公告)号：AU6516799A
公开(公告)日：2000-05-01
申请号：AU6516799
申请日：1999-10-14
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： SUN HOI CHEONG , DESAI NITIN V , ROACH WILLIAM R , LUDINGTON DAVID N , PLETCHER TIMOTHY A , KELLER DAVID , LANG FRANK B , SOUTHGATE PETER D , MCGINN JOSEPH T
IPC: H01L21/683 , H02N13/00
Abstract: Provided is an electrostatic sensing chuck for attracting particles to a portion of a particle contact surface near a deposition electrode, the electrostatic sensing chuck comprising a pixel comprising: a deposition electrode (DE) for selectively establishing an attraction field (Ea) at the particle contact surface; a shield electrode (SE) oppositely biased with respect to the deposition electrode; a charge sensing circuit to measure charge accumulated on each of the deposition electrode and the shield electrode, wherein the charge sensing circuit subtracts a second charge it senses at the shield electrode from a first charge it senses at the deposition electrode, thereby determining accumulated charge at the deposition electrode balanced by accumulated charge at the shield electrode.
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公开(公告)号：CA2346241A1
公开(公告)日：2000-04-20
申请号：CA2346241
申请日：1999-10-14
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： ROSATI DOMINIC S , BRYCKI BOGDAN , SUN HOI CHEONG , POLINIAK EUGENE S , KELLER DAVID , DESAI NITIN V
IPC: G01F1/74 , B01J2/00 , B01J4/00 , B02C19/06 , B02C23/08 , B04C9/00 , B05B5/16 , B05B7/14 , B05C19/06
Abstract: Provided is, among other things, and together with associated methods, a powder feed apparatus including a venturi (120) with an external gas inlet, a gas outlet, and an internal gas inlet, a cyclone (130) with an intake port connected to the gas outlet, a recycle outlet port, and a product port.
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公开(公告)号：CA2333130A1
公开(公告)日：1999-12-16
申请号：CA2333130
申请日：1999-06-08
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： ROSATI DOMINIC STEOHEN , SUN HOI CHEONG , POLINIAK EUGENE SAMUEL , DESAI NITIN VITHALBHAI , SINGH BAWA
Abstract: AC waveforms biasing of bead transporter chucks and their accumulated charge sensing circuits tailored for low resistivity substrates and beads where if traditional DC quasi-static biasing potentials were used, the bead attractio n potentials of the chuck would undergo rapid RC decay and cause the bead transporter chuck to stop working. Methods for selecting AC waveforms are given, including those that maximize the time average of the bead attraction potential at the bead collection zone of the bead contact surface.
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公开(公告)号：NZ517300A
公开(公告)日：2003-11-28
申请号：NZ51730000
申请日：2000-09-11
Applicant: DELSYS PHARMACEUTICAL CORP
Inventor： SUN HOI CHEONG , SINGH BAWA , RIVENBURG HOWARDCHRISTOPHER
Abstract: Provided is a method of moving a charged particle from a first position at which it is retained by a first electrode to a second position at which it is retained by a second electrode, the method comprising: applying a potential to the second electrode to attract the particle; and applying a potential to a guide electrode offset from the particle at the first position, wherein the applied potential is effective to reduce the attraction of the particle to the first position sufficiently to allow the potential applied at the second electrode to be effective to move the particle from the first position to the second position.
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